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Stress linked to growth and spread of cancer in study

University of Texas M. D. Anderson Cancer Center researchers have confirmed what more than a few cancer patients have personally believed for some time now. Stress increases cancer growth and finding ways to relax and reduce stress is beneficial to cancer survivorship.

In a preclinical study carried out on mice with ovarian cancer, researchers found that cancerous tumors grew and spread faster when the mice were experiencing increased levels of stress. According to the researchers, the conclusion of this study is the first definitive link between psychological stress and the biological processes that make ovarian tumors grow and spread. It appears stress hormones bind to receptors directly on tumor cells and, in turn, stimulate new blood vessel growth and other factors that lead to faster and more aggressive tumors.

"The concept of stress hormone receptors directly driving cancer growth is very new," said Dr. Anil Sood, the study's senior author. "Not much had been known about how often these receptors are expressed in cancer, and more importantly, whether they had any functional significance. Our research opens a new area of investigation."

The good news in this -- besides the fact that this study begins to validate what cancer survivors have been saying for years in the personal belief of the link between stress and cancer -- is that stress can be controlled and reduced by lifestyle changes and medication. In fact, the researchers found a beta blocker heart medication effectively blocked the adverse effect stress hormones had on tumor growth.

This could open new areas of research. Indeed, Dr. Sood and his team will continue to research the role of stress in cancer and examine the effects of stress hormones on cancers besides ovarian cancer. To read more about the University of Texas M. D. Anderson Cancer Center preclinical study, go here.

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