All cells in our body are programmed to die. They have a limited lifespan and they die when they are damaged, worn out or no longer needed by the body. This is a normal process called apoptosis, programmed cell death, that the body depends on to be healthy. When cells die they are replaced by new ones.
In cancer cells the process of apoptosis fails and the damaged cells live on and multiply indefinitely and uncontrollably. Most chemotherapy drugs that are given to cancer patients are aimed at killing fast dividing cells, this is sometimes successful at halting the disease but these drugs damage many normal tissues.
Researchers look to find smarter drugs that do not have severe side effects but target only the cancer cell itself. A new drug being studied in the lab suggests that it may prove to be more effective and less toxic than current chemotherapy drugs. The drug called ABT-737 has a different strategy for attacking cancer. Instead of poisoning the cancer cells, the new drug attempts to reactivate the cell death program that had failed.
The leader of the project, Dr. David Huang says "Much more remains to be done to assess the drug's safety and effectiveness in patients, but early results from the laboratory are promising. Our hope is that the new drug will prove to be more effective while having fewer side effects".
