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Pro-vitamin E effective on HER2 positive breast cancer cells

The term vitamin E refers to a family of eight related, antioxidant compounds widely distributed in plants. Pro-vitamin E or alpha-tocopheryl succinate (Alpha-TOS) is found in the green parts of a plant. The best sources of vitamin E are the vegetable and seed or nut oils. It was first isolated from wheat germ oil, which is still a commonly used, rich source of vitamin E.

Researchers at Griffith University's School of Medical Science have shown that pro-vitamin E can reduce tumor volume on animals with high levels of HER2. The researchers think it has potential to be an inexpensive, safe and selective therapy for hard to treat breast cancers.

Jiri Neuzil, chief investigator and Associate Professor, said "Alpha-TOS has already shown promise as a potent anticancer agent in diseases such as colon cancer and mesothelioma. It induces controlled cell death or apoptosis in tumor cells".

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