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Another attack on HER2 comes in form of vaccine

There are sometimes silver linings to the darkest of cancer clouds. I know -- because I have the dark cloud of HER2 positive breast cancer hanging over my head. HER2 positive means the tumor removed from my breast was aggressive. It aggressively over-expressed a protein that accelerates tumor growth. And it led to a poor prognosis -- that might be considered a good one too.

You see, research on the whole HER2 issue is turning up some pretty powerful potions. Like Herceptin -- the drug that miraculously cuts recurrence upwards of 50 percent for positive women like me. I was a lucky recipient of this drug. And the pharmacist who mixed the drug for all 17 of my infusions tells me it's really a good thing I have this HER2 problem -- because the drugs created to attack the problem may just cure me of my disease.

So in an odd turnabout -- from bad luck to good fortune -- I am not so sad my tumor was aggressive. It means there are bonus treatments for me. And if my cancer comes back and Herceptin no longer works, there is another drug called Tykerb. And now the Army is leading its own breast cancer vaccination study. The focus -- HER2.

Early study results from Walter Reed Army Medical Center in Washington, D.C. suggest a 50 percent reduction in disease recurrence for HER2 positive women who receive a vaccination of AE37.

AE37 targets HER2 and boosts the body's immune system so it can battle the protein before it stimulates growth. It's similar to Herceptin, but the activity of AE37 stimulates a patient's own immune system to recognize the cancer target rather than interacting with the target directly.

Should the Food and Drug Administration decide to support this study, it will proceed to Phase 3 testing, which includes a much larger pool of participants.
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