St. Jude finds factors that indicate resistance in acute lymphoblastic leukemia (ALL)

Note: The contents of this blog are for informational purposes only and should not be construed as medical advice or substitute for professional care. For medical emergencies, dial 911!

St. Jude finds factors that indicate resistance in acute lymphoblastic leukemia (ALL)

Posted Sep 9th 2007 8:16AM by Patricia Mayville-Cox
Filed under: Leukemia

Results of a study at St. Jude show why imatinib (Gleevec) is unable to prevent the relapse of an aggressive form of acute lymphoblastic leukemia (ALL). Imatinib has improved the treatment of chronic myelogenous leukemia (CML) dramatically.

CML and an aggressive form of ALL share the same mutation, the Philadelphia chromosome (Ph). Ph-postiive cells produce a growth-promoting enzyme BCR-ABL. However, in some aggressive cases of ALL, Ph-positive cells lack a tumor suppressor gene called Arf, which is present in CML cells, say the researchers.

The paper's first author, Richard T. Williams, says that doctors might be able to identify those people with ALL who lack Arf.

Tags: acute lymphoblastic leukemia, AcuteLymphoblasticLeukemia, ALL, Arf, BCL-ABL, chronic myelogenous leukemia, ChronicMyelogenousLeukemia, CML, Gleevec, imatinic

Reader Comments

(Page 1)

1. hi there, the link on the work STUDY appears to be broken - can you post the correct one

thanks

Rob - http://cmlblog.spaces.live.com

Posted at 2:27PM on Sep 10th 2007 by cmlblogger

2. The link should be there now. Thanks for letting me know! Patricia

Posted at 2:36PM on Sep 10th 2007 by Patricia



Pay-per-mile car insurance might come to California Azure Dynamics gets FedEx order for 51 hybrid vans Lithium battery recycling facility suffers explosions, fire Renault announces 2011 production of all-electric Kangoo van Garmin Eco-Route cable will sell for $149, could appear soon Subscribe with My AOL, MyYahoo or Bloglines	Vote for Our Halloween Costume Contest Winners! Girls on Film: Domestic Violence and Media 'Up in the Air' Songs Pulled from Oscar Race Aronofsky's 'Black Swan' Gains More Cast Members Walmart, Target and Amazon Slash DVD Prices Subscribe with My AOL, MyYahoo or Bloglines
Ray of light: U.S. temp worker hiring increased by 34k in October Cameron International: Pull-back is an opportunity Twenty years ago today, economic freedom returned to Eastern Europe Kim Jong-il: No more TV commercials in North Korea Closing Bell: Bulls gutting bears (ATVI, EWBC, GE, JASO, ENZN, MCD) Subscribe with My AOL, MyYahoo or Bloglines	Mom Loses 340 Lbs. to Regain Her Kids A Supplement That Burns Belly Fat? An Appetite Suppressant You Already Eat, 10 Funniest Workout Videos and More: Links We Love Build Muscle Even Faster! Stressed Women Eat High-Calorie Comfort Food, Study Finds Subscribe with My AOL, MyYahoo or Bloglines
Top state parks in each state offer options for seeing native wildlife Photo of the day 11.09.09 Gadlinks for Monday 11.9.09 Battle of the bulge: Breeding season starts soon for elephant seals at Año Nuevo Walking with the angels at Zion National Park Subscribe with My AOL, MyYahoo or Bloglines	Review: Desperate Housewives - Careful the Things You Say Recap: Dancing with the Stars - Performance 8 Review: Heroes - Shadowboxing Review: Californication - So Here's The Thing... Review: Two and a Half Men - Untainted by Filth Subscribe with My AOL, MyYahoo or Bloglines
Where to Buy Your Honey Baked Ham Online Sierra Nevada Harvest Wet Hop Ale - Beer of the Week 10 Catchiest Food Jingles We Love to Hate LeNell It All - Jamaica 'Quick From Scratch Italian Cookbook' - Cookbook Spotlight Subscribe with My AOL, MyYahoo or Bloglines	VIDEO: BMW M3 GTS takes to the track CR&S DUU Concept is a mototerminator for the rest of us Daily U-Turn: What you missed on 11.9.09 Besting Prodrive: Autodelta unveils tuned Alfa Brera S and 159 J4 3.2 Compressore at MPH09 REPORT: Stand-alone Lincoln-Mercury dealers being scaled out of existence Subscribe with My AOL, MyYahoo or Bloglines