Researchers at Harvard Medical School say the active component of marijuana may enhance the virus that causes a rare type of skin cancer called Kaposi's sarcoma. While most people are not at risk of developing this cancer, AIDS patients are transplant recipients are. It's the weakened immune system that puts some at risk for this disease. And these are the people who should discuss with their doctors the costs of using marijuana medicinally or recreationally.

It may take only small doses of tetrahydrocannabinol (THC) -- the ingredient that gives marijuana users a "high" -- to cause cells to become infected and then multiply, according to a study reported in the August 1 issue of Cancer Research.

Previous studies have indicated this very same association between marijuana use and Kaposi's sarcoma. But this study shows THC itself is the driving force.

More and more media reports are mentioning the potential merits of marijuana. The most recent headlines say the active ingredient in the drug cuts tumor growth in common lung cancers in half and greatly reduces the ability of the cancer to spread.

Researchers at Harvard University tested marijuana's main ingredient, delta-tetrahydrocannabinol or THC, in both lab and mouse studies and say their experiments are the first to show THC inhibits the growth of cancer.

Researchers are not certain why THC inhibits tumor growth, but it could be that the substance activates molecules that arrest the cell cycle. THC may also interfere with angiogenesis and vascularization, which promotes cancer growth.

There is a long way to go in the study of THC. Yet "the beauty of this study is that we are showing that a substance of abuse, if used prudently, may offer a new road to therapy against lung cancer," says Anju Preet, Ph.D., a researcher in the Division of Experimental Medicine.

When I told my husband that the use of cannabis is being linked to a five percent increase in lung cancer risk -- that's 15 new cases each year in New Zealand where a study was just conducted -- he seemed to think this risk is comparable to his dying from a grasshopper landing in his eye.

A scientist John is not, but his thoughts on the matter seem to parallel international thinking on the drug which goes something like this: the risk marijuana use has on cancer incidence is so very low it's hardly worthy of much worry.

A California study of more than 1600 people last year found no link between cancer and smoking the drug, despite researchers' prediction they would find some kind of connection.

New Zealand researchers have found a connection, though, and however small it may seem, they say it's significant.

They found the risk of developing lung cancer increased by about eight percent each year for people whose cumulative exposure equated to smoking one joint per day -- about the same as the increase for someone who smokes one pack of cigarettes per day. They also found the younger someone starting smoking cannabis, the greater the risk and that contributing risk factors include smokers' deeper inhalation and the tendency to hold smoke in their lungs.

Cannabis, the most commonly used recreational drug in the world with 161 million users, has been thought to have a protective effect against cancer due to its chemical THC, which appears to kill aging cells and keep them from becoming cancerous. This study may prove otherwise.

Medical marijuana advocate Ed Rosenthal has been indicted again by a federal grand jury on a number of counts including conspiracy to manufacture and distribute marijuana; money laundering and filing false tax returns related to a marijuana operation.

This is not the first time Rosenthal has been brought up on charges involving medical marijuana activities. Three years ago, he was convicted for cultivating marijuana for a city of Oakland medical marijuana program. An appeals court overturned the conviction this past April, citing jury misconduct, but it upheld federal powers to charge marijuana growers.

The Ask Ed columnist for High Times magazine Rosenthal, 61, known as the Guru of Ganja and author of marijuana cultivation books, is quoted as saying, "What they're trying to show is that they can close down anybody, a legitimate club, a legitimate provider who's sanctioned by the city. They're trying to stop patients from getting their medicine."

Other medical marijuana-related posts include:

• Montel Williams: poster child for pot
  
• Medical marijuana pot pill approved for chemotherapy
• Breast cancer has made me a criminal patient story
• FDA rejects medical marijuana use

Medical use of marijuana on a doctor's recommendation is legal in a number of states but prohibited by federal law.

When Montel Williams testified before the Senate Health, Human Services and Senior Citizens Committee in favor of medical marijuana for chronically ill patients, he referred to himself as a poster child for pot. Williams, who hosts a television talk show, was diagnosed with multiple sclerosis almost a decade ago.

MS can cause debilitating pain. For those who might be unaware, let me share with you that Williams does not exaggerate. My sister-in-law suffered from MS all of her adult life, before losing her life to MS at the age of 40, and I will tell you first-hand, there is suffering. When I think of all the life that MS stole from her, and all that she endured, I feel frustration towards anyone who would have denied her the best quality of life available. I am fed up with the lack of compassion of those who would deny anyone suffering from chronic or life-threatening disease the best quality of life available to them. For Williams, it is medical marijuana that offers him the best quality of life possible.

There are as many carcinogens in marijuana as there are in tobacco, but researchers were surprised to find that people who smoke marijuana are not at an increased risk for developing lung cancer. In fact, marijuana smokers might be receiving a weak level of cancer prevention. People who smoke cigarettes are definitely at a greater risk for developing cancer as a result of smoking, and the more they smoke tobacco, the greater the risk for cancer. But pot smokers do not seem to share the same risk.

According to researchers, and the research, even very heavy, long-term marijuana users who had smoked more than 22,000 joints over a lifetime seemed to have no greater risk than infrequent marijuana users or those who never smoked.

Wondering why? Researchers believe it is the THC in marijuana that acts as protection against the damage experienced by any carcinogens a marijuana smoker is exposed to while smoking. Past research has shown that THC has anti-tumor properties. So much for that argument against medical marijuana use.

Valeant Pharmaceuticals International announced that the U.S. Food and Drug Administration has approved Cesamet, a synthetic cannabinoid, THC, for treatment of nausea and vomiting associated with cancer chemotherapy in patients when conventional antiemetic treatments have failed. According to the American Cancer Society, approximately 70 to 80 percent of patients undergoing chemotherapy experience nausea and vomiting.

Current medications to relieve the side-effects of nausea and vomiting only work for less than half of cancer patients during chemotherapy. Cesamet as a prescription drug should be available in less than a month. Synthetic THC acts on the brain like the THC in smoked marijuana -- but eliminates having to inhale the otherwise harmful smoke contained in the illegal drug. Recently, the FDA made a public statement that it did not support the use of medical marijuana.

"On the night of my first round of chemotherapy, exactly six hours after I left the oncologist's office wondering what all the fuss was about, my stomach tumbled into my knees, my knees refused to work altogether, and I crumpled to the floor in a clammy, shivering heap.
   
I lay there until dawn, at one point vomiting on myself, at another crying that I'd rather die of cancer than undergo chemo again."

Breast cancer made me a criminal is a Boston Globe opinion piece written by Lynda Gorov -- a breast cancer patient who shares a personal account of the misery she suffered from the side effects of chemotherapy treatment and her choice to turn to the possible use of marijuana for relief. She pulls no punches and makes a good point, by way of using herself as an example, for the benefits of medical marijuana use and the ludicrous stand the government has taken to the legalities of marijuana for medical purposes. If you are sitting on the fence on this issue, or have never gone through chemotherapy and might not appreciate the grueling life-debilitating experience, her editorial is a fair one to read.

While Queen Mary's School of Medicine Dr Wai Man Liu and researchers were studying the role of cannabis, commonly known as marijuana, in cancer therapy, they discovered the main active ingredient in cannabis, tetrahydrocannabinol, THC, has the potential to destroy leukemia cells and other cancer cells. Cannabis has been well-established and recognized as an effective treatment in the remedy for nausea caused by chemotherapy and as a medication for pain. The researchers, using highly sophisticated microarray technology were able to detect changes in more than 18,000 genes in cells treated with THC, and were able to discover the existence of crucial processes through which THC can kill cancer cells and potentially promote cancer patient survival.

Due to widespread illegal use of cannabis as a recreational drug, its legal or licensed use in medicine is now a controversial issue in most countries. Currently, there are eleven states with effective medical marijuana laws on the books: Alaska, California, Colorado, Hawaii, Maine, Montana, Nevada, Oregon, Rhode Island, Vermont, and Washington. However, the United States federal government does not recognize any legitimate medical use, and state laws have been challenged.

Dr Liu states, "It is important to stress that these cannabis-like substances used in research are far removed from the cannabis that is smoked. These novel compounds have been specifically designed to be free of the psychoactive features, while maintaining anti-cancer action." Medical marijuana for nausea and pain is known to be administered by smoking marijuana.

Steven Wynn Kubby has withdrawn his request to use cannabis to treat his adrenal cancer while he serves a sentence in jail. Kubby, who is currently serving a 120-day jail sentence for a drug conviction, has been prescribed the drug Marinol, a synthetic form of marijuana's active ingredient, THC to help lower his blood pressure.The high blood pressure stems from his form of cancer known as pheochromocytoma, a rare disease of the adrenal glands above the kidneys. The tumors on the adrenal glands cause an increased production in adrenaline and other hormones that affect blood pressure, heart rate and sweating. Symptoms of the disease include sudden or sustained high blood pressure that often resists treatment. Sweating, nausea, headaches, rapid pulse or heart palpitations are other symptoms that Kubby has successfully treated with medicinal marijuana. While Marinol is currently helping to control Kubby's blood pressure, his lawyer stated that if his health begins to deteriorate Kubby will again request the use of edible marijuana to relieve his life threatening symptoms.