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Posts with tag cardiac

Heart disease after Hodgkin's lymphoma treatment

Those who have been treated for Hodgkin's disease have a 3.6 fold increased risk of heart attack and a 4.9 fold increased risk of congestive heart failure than the general population.

A study was conducted to assess the long-term cardiovascular disease risk in a group of 1474 patients, who survived Hodgkin's lymphoma for at least five years.

Records showed that 28 percent received radiation only; 5 percent had chemotherapy only; 38 percent were treated with radiation and chemotherapy, which did not include anthracyclines, drugs known to damage the heart; and 29 percent received radiation plus chemotherapy with anthracyclines. Of these patients, a total of 84 percent were treated with radiation to the chest.

The study group detected 160 cases of valve disorders, 134 cases of angina, 102 heart attacks and 52 cases of congestive heart failure. Among subjects treated before the age of 20, the risk of angina and congestive heart failure were significantly higher than for those treated when they were older, suggesting that "immature cardiovascular tissue may be more vulnerable to radiation and chemotherapy."

The study team hopes that the outlook for survivors of Hodgkin's lymphoma will brighten over time, as fewer patients are receiving radiation therapy, and when they do, dosages are reduced and patients' hearts are at least partially shielded.

The recommendation for those treated for Hodgkin's is to consider some risk reducing strategies, such as treating high blood pressure and high cholesterol and advising patients to eliminate controllable risk factors.

This post isn't meant to scare anyone diagnosed with Hodgkin's that has been treated with radiation or chemotherapy. I was given an anthracycline as therapy for my breast cancer -- it does linger in the back of my mind that this drug is harmful to the heart and could cause problems later on in my life. I think that those treated for Hodgkin's, especially at a young age when treatments might have been less safe, should think about their lifestyle choices. Talk to your doctor about ways to decrease your risk of these heart problems.

Obesity: stomach stapling for children

Stapling the stomach of an obese child is a last resort, but the National Institute for Health and Clinical Excellence (NICE) has issued a stamp of approval for bariatric surgery as part of a national guideline aimed at reducing obesity in children and minimizing the long-term adverse health effects that being overweight has on health.

This is the NICE organization's effort to find solutions to England's rising obesity epidemic where the number of overweight and obese people in the last quarter century has tripled.

Stomach stapling is not the only solution, but it is now an approved option. Other recommendations include the following: local authorities working with local partners, such as industry and voluntary organizations, to create safe spaces for physical activity; providing cycling and walking routes, cycle parking, area maps and safe play areas; creating pedestrian-friendly streets; designing building and spaces to encourage more physical activity; requiring schools to provide an environment that promotes healthy eating and physical exercise; healthcare professionals taking the time to educate and give advice on how to maintain a healthy weight; raising public awareness and encouraging daily physical activities such as walking, cycling, swimming, aerobics or gardening.

Obesity cannot go unchecked and it is a threat to the health and welfare of children and adults alike, as obesity is linked to greater increased risks for a number of life-threatening diseases like heart disease, diabetes and cancer. But, it is uncomfortable to think that one of the solutions to childhood obesity is a scalpel. The NICE press release New NICE guideline calls for urgent action to stem the rising tide of obesity in England and Wales is available as a pdf document here.

Healed by the power of flowers

Flowers can lift spirits, brighten days, and heal hurting souls. They can actually make us healthier too. And while there is not a lot of science backing this fact just yet, it's long been understood that flowers really do help us Get Well Soon.

In ancient Egypt, physicians ordered walks in gardens for patients with psychological problems. Currently, horticultural therapy is a well-established method of rehabilitation for patients with physical and mental difficulties. Medical institutions all over have created flowering spaces intended as therapeutic gardens. One study determined that 100 percent of women presented with a flower bouquet reacted with a genuine smile that involves the eyes and the mouth and indicates changes in the brain. There was no such common happiness reaction among women presented with other gifts. Further studies found that men also reacted positively to flowers. A study of cardiac patients found flower therapy improved mood and lowered heart rates, possibly reducing stress that contributes to heart disease. It seems some patients seem to forget about their pain when strolling through gardens. They forget about their pain medication too. One flower expert's research brightened her own world at a time when chemotherapy and surgery for breast cancer had her feeling pretty low. Studying flowers gave her a whole new, brighter look at the world.

Flower therapy includes almost any contact with plants. Color, texture, and scent all play a part in the relaxation and healing that results from a little flower time. Why it works is a mystery -- it could be that we associate flowers with pleasure, that flowers fulfill emotional needs, that they are the pets of the horticultural world. We breed them for traits that please us and then capitalize on how they lighten the load and enhance our moods.

The bottom line is this -- we just don't know exactly why or exactly how flowers do what they do. We just know intuitively that they work, that they spread hope and renewal and peace like nothing else.

For more information on the healing power of flowers, pick up a copy of the November 2006 issue of The Oprah Magazine.

A look at Herceptin and cardiac toxicity

Researchers at M.D. Anderson report on long-term cardiac status of patients receiving Herceptin. Trastuzumab (Herceptin), an anti-HER2 monoclonal antibody, is highly effective for treating HER2 overexpressing invasive breast cancer. In patients with HER2 positive metastatic breast cancer, Herceptin plus chemotherapy improved disease progression and overall survival compared with chemotherapy alone.

The study included patients who received Herceptin for at least one year. Most patients with Herceptin associated cardiac toxicity recovered completely, and many were re-treated with Herceptin without additional cardiac toxicity. Some patients did not discontinue use of Herceptin despite cardiac dysfunction.

This report suggests that patients who experience Herceptin induced cardiac toxicity should be managed with cardiologists and decisions to continue or resume Herceptin must be made after careful discussion of potential benefits and risks associated with further therapy.

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