Way to go Wake Forest University scientists -- for adding to the body of evidence connecting stress to illness and for reporting before anyone else that the stress hormone epinephrine causes changes in prostate and breast cancer cells that may make them resistant to death.

Emotional stress contributes not only to the development of cancer, says lead researcher George Kulik, D.V.M., Ph.D, but it also reduces the effectiveness of cancer treatments.

Previous research shows levels of epinephrine, produced by the adrenal glands, are sharply increased during stressful situations and can stay elevated during long-term stress and depression.

During this study, published in the on-line Journal of Biological Chemistry, Kulik and colleagues found that a protein called BAD -- the cause of cell death -- becomes inactive when cancer cells are exposed to epinephrine.

This is huge for patients and researchers.

"It may be important for patients who have increased responses to stress to learn to manage the effects," said Kulik. "And, the results point to the possibility of developing an intervention to block the effects of epinephrine."

If clinical trials go well, a new drug simulating the effects of normal sunlight and increasing the life expectancy of prostate cancer patients, could be available in 2009.

The drug, Asentar, provided levels of vitamin D between 50 and 100 times higher than levels delivered by the sun and could double life expectancy from nine to 18 months for those taking the pills. Absent would be any of the consequences associated with such an overdose.

"An extension of nine months would be very significant in my view," said Nick James of the University of Birmingham. "If the results of the phase III trial are as good as those of the phase II trial, that would be significant."

Details about this study can be found in the journal Chemistry & Industry.

A chemical found in hard plastics -- such as CD cases, baby bottles, food-storage containers, and even electronics parts -- has been loosely linked to incidences of breast cancer. Popular opinion cautions that if we were not worried about this news yesterday, we should not be worried about it today -- because studies are preliminary and nothing is definitive at this point. But there are definitely two sides to the debate over how harmful these hard plastics may be.

The chemical in question -- a pseudo-estrogen called bisphenol-A (BPA) -- appears to be absorbed by breast tumor cells, according to a new study published in the August 28 issue of Chemistry & Biology. Previous studies have linked small exposures of BPA to prostate abnormalities in mice that suggest a link between the plastic chemical and human prostate cancer. Some studies even theorize that embryonic and fetal exposure might influence mental retardation and birth defects. And because this pseudo-estrogen is a synthetic material that in human cells can trigger estrogenic effects, breast cancer now comes up as a disease that may result from this questionable chemical.

Critics say that average levels of the chemical found in urine is infinitesimally small -- about one part per billion. Some say the results of this research come from in-vitro studies that one expert says can never fully explain human disease. Yet the real crux of the matter, according to another expert, is that we are surrounded by all sorts of chemicals that are pseudo-estrogenic -- not just BPA -- and it's the cumulative effects that we do need to worry about.