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Posts with tag complex

Cancer research complex where horses once roamed

I drove by the farm-like land for years and years, watching horses from my car window on my way to class, to the university hospital, to other parts of town. I was first a college student, merely noting the vast property. And then I was a mom with two little boys and a definite interest in this acreage. I acquired a passion for this corner lot -- across from the Cancer Center that ten years later became a typical haunt -- and I often found myself driving, pointing, gesturing, shouting, "horses, horses, look at the horses."

There are not many horses left on this land. There is, however, one very large building with a very important sign announcing its presence on the University of Florida campus. The sign reads, Cancer and Genetics Research Complex -- and what a complex it is.

On November 15, officials dedicated this $84.5 million, 280,000 square-foot facility, promising the University of Florida will be at the forefront at cutting-edge cancer research.

A five-story cancer research wing and a six-story genetics research wing are just two of the multidisciplinary entities housed in this new complex, designed to maximize collaborations among researchers and to convert science into innovative cancer therapies and technologies.

"This building is bricks and mortar, but it's much more than that, because it really provides hope for cancer patients, who know that we're going to do the research, we're going to find the answers, we're going to help them," says the director of the UF Shands Cancer Center.

I am one of those cancer patients. And while I'm sad for the horses who lost their homes and my boys who can no longer admire these creatures, I am happy for the beacon of hope that sits prominently on the farm-like land I've been watching for years and years.

Role of sugars in spread of cancer

Can a spoonful of sugar treat cancer? No. Actually, the lack therof, might prove a valuable tool in halting the spread of cancer. Leading scientist Dr Robert Falconer is trying to develop new drugs based on the knowledge that there exists on the surface of cancer cells 200 identical simple sugars that make up a long molecule called polysialic acid -- and the more polysialic acid on cancer cells the easier the spread of cancer cells.

And if you are thinking -- well -- that sounds like a rather simplistic explanation of the science behind the research Dr Falconer is involved in regarding the study of sugars on the surface of cancer cells -- you might be right. Then again, according to Dr Falconer, it might be rather simple and yet largely ignored as it has been in preference of research that has focused more on the proteins found on the surface of cancer cells.

The surface of cells carries a complex mixture of proteins and sugars.

The Association for International Cancer Research (AICR) thinks Dr Falconer might be on to something, as they are providing funding for three years of additional research into finding new molecules to stop the increased polysialic acid production cancer cells seem to count on before their move beyond the original tumor location.

Simplicity steers family through complexity of cancer

I told my little guy Danny today that he and his big brother would be going to their Nana's house so I could go to the doctor -- for an echo-cardiogram to test for possible heart damage due to Herceptin therapy for breast cancer. Danny -- age three -- asked me, Why you keep doing that? This is the same question he keeps asking -- because he wants to know why I keep going to the doctor. I give him the same answer each time -- that I need to keeping seeing doctors so I can stay healthy. He always seems satisfied with this response, although he continues to ask the same question. He either forgets that he's already asked or he forgets my response or he finds comfort in my routine answer -- or perhaps he is completely aware of his repeat question and just wants me to provide a better explanation. Which is hard to do -- in a three-year-old kind of way -- when my response is the best I've got. I keep going to the doctor in search of health. It's simple. And fortunately, so is Danny -- simple in a young and innocent and pure way. And Joey is too.

Right after my exchange with Danny, Joey -- age five -- said to me, Won't you be glad when you don't need to go to the doctor and you can be healthy all by yourself? Yep, I told him and then realized that these boys have a definite pulse on my cancer journey -- almost two years after it started. They wonder about it and try to figure it out and predict how I must feel. And through it all, I am happy they are involved with me in this intricate adventure. And I am concerned at the same time that what they do know may cause them some stress, some worry, some uncertainty about our future together. My hope is that this experience in their young lives strengthens them, humbles them, prepares them for a future that is not always as simple as the responses I give them about an illness that is so complex. But when it comes down to really simple terms -- that we all can appreciate -- I have my boys and they have me and for today, that is all that matters. Well, that and the fact that my echo-cardiogram today revealed that my heart is just fine.

Frank Zappa: Dweezil sets the record straight

"A composer is a guy who goes around forcing his will on unsuspecting air molecules, often with the assistance of unsuspecting musicians." -- Frank Zappa

Frank Zappa -- intelligent and articulate; gifted and prolific as a rock musician and composer; guitarist, singer/songwriter, film director, and satirist -- lost his life to prostate cancer in 1993. During his musical career, he gained a cult-like following of fans by pushing the iconoclastic envelope and by mastering the technology needed to create his complex musical compositions.

One of Frank's sons, Dweezil Zappa, wants to set the record straight about his father. According to Dweezil, "There are so many things that are misunderstood or not recognized about my father's music because they've been filtered by people who work for magazines like Rolling Stone.

For example, Rolling Stone recently printed a poor, artist-rendering of Frank holding a joint.

Frank has always been well-known for being anti-drug yet they would rather continue to perpetuate a false image of him, even after death. It's irresponsible, it's obnoxious and offensive. I think it's time people know what Frank was really about, and they should discover it through his music."

To that end, Dweezil, with his brother Ahmet, are touring Zappa Plays Zappa and introducing a whole new generation to Frank Zappa's music. You can follow the tour at the Zappa Plays Zappa blog.

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