Lung cancer tumors in mice are shrinking -- with the help of a hormone important in the control of blood pressure.This new discovery, led by scientists at Wake University School of Medicine, suggests some drugs used to manage blood pressure might also prevent or treat lung cancer.
This all came about when it was noticed that lung cancer rates were lower among those treated for high blood pressure with angiotensin-converting enzyme, or ACE, inhibitors. These drugs, including Capoten and Lotensin, increase levels of angiotensin-(1-7) in the bloodstream.
In studies, the angiotensin-(1-7) hormone caused a 30 percent decrease in tumor volume in mice. Tumors in mice not treated with the hormone more than doubled.
This study, published in the journal Cancer Research, is the first demonstration of the effect in animals.
