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Posts with tag cytoxan

Shades of cancer

My hair is changing -- again. It started out perfectly straight, blond, and shoulder length. Then it came tumbling out, thanks to the chemotherapy drugs adriamycin and cytoxan. Four months later, it was back -- curly, dark, and way too short for my liking.

Over the past two years, I've grown to enjoy my hair. The longer it gets, the less curl it keeps. I like it this way. The color has grown on me too. When I look back at photos of my lighter locks, I think dark suits me better. Why do I get the feeling, though, that my hair won't be dark for long?

I still think of my hair as dark, I guess because it was once so very blond and it is so very not blond at the moment -- in my opinion anyway.

Continue reading Shades of cancer

New standard of care for the most common form of adult leukemia

Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in adults. According to the National Cancer Society an estimated 60,000 people are living throughout the United States with CLL.

An article published in The Lancet stated that the chemotherapy combination of Fludara plus Cytoxan improves progression free survival compared to therapy consisting of Fludara alone. The drugs used to treat CLL consist of Fludara, Cytoxan and chlorambucil. Recent studies have shown that Fludara in combination with Cytoxan to be the most effective treatment for CLL.

Researchers wanted to test to see if higher anticancer responses were seen with the combination of Fludara plus Cytoxan, treatment with Fludara alone or treatment with chlorambucil.

Continue reading New standard of care for the most common form of adult leukemia

Timing of treatment works for and against us

My new breast cancer friend recently sat through her second infusion of Adriamycin and Cytoxan -- the long-time traditional chemotherapy combination for breast cancer -- and all the while, listened to another breast cancer survivor share her thoughts on these two drugs.

This woman told my friend she opted to stray from these chemotherapy agents because of their toxic side effects, because of their combined potential for causing other cancers, like leukemia. She instead took another drug route and was happy for her decision. My friend, however, was scared.

My friend returned home from her treatment and found herself reading a Cancer Blog post reporting that Adriamycin and Cytoxan may no longer be the gold standard treatment for breast cancer, that Taxotere and Cytoxan may become the preferred, safer option.

Fear and panic set in, and my friend e-mailed me, in search of perspective from a recipient of the drugs she was starting to believe are both ineffective and cancer-causing.

I am not a doctor. I am not an expert. I am not qualified in any way to represent the facts about medical research. But I am surviving breast cancer. And I did spend eight difficult weeks under the influence of Adriamycin and Cytoxan, given every two weeks in a dose-dense fashion. So I have an opinion about these drugs -- and about most things breast cancer related.

I shared my opinion with my friend, who has since decided to proceed with her prescribed treatment plan. I told her that in rare cases, chemotherapy can cause a second cancer, like leukemia. But this is not common, and the unlikely risk does not outweigh the benefit of receiving chemotherapy to address the cancer at hand.

I also shared with my friend that we can only benefit from therapies that are available and effective at the time of our treatment. Studies prove that Adriamycin and Cytoxan work -- that's why so many women are treated with this accepted method. Drugs in the research pipeline may one day definitively replace what is available today. But we must be OK with what we receive -- because we have no control over what lies ahead. We must live in the here and now -- with the knowledge that should our cancers return, bigger and better options may await us.

Consider Herceptin. Once not even an option for women with aggressive HER2 positive breast cancer, this targeted drug may be the magic bullet in an attack against this disease. I received Herceptin. My friend will receive Herceptin. Timing was on our side for this medical breakthrough.

Timing may not have been on our side should a new gold-standard drug treatment emerge and replace Adriamycin and Cytoxan. But we can still trust these two drugs will do their jobs, will prevent a recurrence of a disease that is so much more treatable today than it was years ago. Lucky for us.

Should Taxotere plus Cytoxan be the new gold standard for breast cancer treatment?

The results of a Phase III clinical trial, published in the Journal of Clinical Oncology, concluded that Taxotere (docetaxel) plus Cytoxan (cyclophosphamide) resulted in better cancer free survival than the treatment combination of Adriamycin (doxorubicin) and Cytoxan (cyclophosphamide).

Adriamycin and Cytoxan, referred to as the AC chemotherapy regime, has been the gold standard for adjuvant therapy for those patients diagnosed with early stage breast cancer. This study was conducted on more than 1000 women who had Stage I to Stage III disease. Half of the women were given the AC regime and the other half given the Taxotere/Cytoxan (TC) regime.

The results of the study showed that cancer free survival was 86 percent for those treated with TC an 80 percent among women treated with AC. Overall survival was 90 percent among women treated with TC and 87 percent among women treated with AC. Nausea and vomiting were more common among women treated with AC. Muscle and joint pain, edema, and low white blood cell counts accompanied by fever were more common among patients treated with TC.

Survivor Spotlight: Cynthia Yousefi can handle anything now

Cynthia Yousefi is a wife and mother of three living in Granada Hills, CA. She is 42 years old and works as an analyst for a Federal agency. She and her family enjoy trips to Harrah's Rincon Casino in San Diego -- and while the destination is a favorite, the sights along the way also bring them pleasure. Cynthia enjoys museums and amusement parks and swimming and evening walks. She enjoys a lot these days because she feels she's been given a second chance at life -- now that she is surviving breast cancer.

Continue reading Survivor Spotlight: Cynthia Yousefi can handle anything now

Survivor Spotlight: Wendy Chioji reports on breast cancer

Since 1988, Wendy Chioji has been a reporter and anchorwoman for WESH 2 News in Orlando, Florida. She has covered news ranging from the pope's visit to Cuba in 1998 to the Olympic Winter Games in Salt Lake City in 2002. She continuously covered last year's hurricanes, and she has an Emmy award under her belt for a special news report on heroin use.

Wendy is a top notch athlete. She has run five marathons and competed in several triathlons and half-ironman races. She has ridden in parts of several stages of the Tour de France, and traveled across the country with Lance Armstrong in 2003 -- covering 550 miles -- with the Tour of Hope event to raise awareness for cancer research. Wendy has also made a tour with stage II breast cancer. Since 2001, she has been surviving this disease.

Continue reading Survivor Spotlight: Wendy Chioji reports on breast cancer

Survivor Spotlight: Every moment matters for Kim Taylor

Kim Taylor is a 45-year-old single mother who lives in Suwannee County, Florida and is proud to have successfully raised one daughter -- a graduate of the University of Florida. Kim enjoys outdoor activities like camping as well as sewing, crafting, and carpentry projects. She is most at peace spending time with her family, working as a youth volunteer -- and raising awareness for breast cancer. It's a interest she acquired just two years ago, compliments of a personal encounter with the disease that has taught her to let the little things go, to appreciate every sunrise, to make every moment matter.

Continue reading Survivor Spotlight: Every moment matters for Kim Taylor

UK patients angry as new bowel cancer drugs are rejected

I feel fortunate to have received every cancer drug I needed to fight my breast cancer -- Adriamycin, Cytoxan, Herceptin, and every nausea pill, pain capsule, and anti-anxiety formula on the market. I got exactly what doctors thought I needed -- without worry about availability or funding or politics. I am lucky. Some in the UK are not so lucky.

Two targeted therapies for bowel cancer will not be used in Britain's state-run health system, according to NICE -- the National Institute for Health and Clinical Excellence. NICE, the country's financial watchdog, determined the high cost of the medicines meant their use was not compatible with the best use of resources. Patients are angry because these same two drugs -- Avastin and Erbitux -- are used widely in the United States and in much of Europe. And while neither drug offers a cure for bowel cancer, both treatments have been shown in clinical trials to extend life expectancy by four or five months in some patients.

Based on doses given during the trials, it is estimated that the average cost of treating one patient with Avastin would be around 16,800 pounds and with Erbitux -- about 11,700 pounds. Apparently, this is too much. But according to Hilary Whittaker of the charity Beating Bowel Cancer, the decision to deprive patients of this medication is a scandal. I agree. And for these patients, I am sad.

Breast cancer chemotherapy tougher on young women

Just before my chemotherapy for breast cancer started -- when I was fantastically frightened by the toxic drugs that were about to drip into my veins -- I was told by doctors, nurses, survivors, friends that I would be just fine. I was young and strong and tough. I would easily tolerate the beating my body was about to take. This is what I was told and actually came to believe myself. I had no other choice really than to approach chemotherapy with a fighter mentality. And so I did. And I did pretty well for my first three doses of Adriamycin and Cytoxan -- given every two weeks instead of three in a dose-dense fashion -- followed by one injection of Neulasta 24 hours later to maintain normal blood counts. And then something happened. And I did not end up tolerating the chemotherapy my gut told me was a scary endeavor.

Continue reading Breast cancer chemotherapy tougher on young women

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