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Posts with tag damage

Left-sided breast cancer radiation spikes heart risk

I hate it when I fit the mold for some not-so-great research finding. Like the recent news about how women with early-stage cancer of the left breast (that's me) who are treated with radiation following lumpectomy (me again) face an increased risk of developing radiation-related coronary damage.

OK, so the benefits of radiation therapy still outweigh the risks. Still, when radiation is applied to the breast on the same side as the heart, there are worries. I knew about these concerns. My radiation oncologist addressed them prior to my treatment. Hearing that an actual, important, convincing study confirms what I already knew may be a side effect, though, makes my heart race a little bit more.

There were 961 women with stage I and II breast cancer who were followed in this study. Well, the arteries in their hearts were studied anyway. Some had left-sided breast cancer; the others had right-sided. Some 12 years after radiation, 46 of the 485 left-sided women and 36 of the right-sided group needed cardiac stress testing. Among those tested, 59 percent in the left-sided group had abnormalities. Only 8 percent in the right-sided group showed problems.

Continue reading Left-sided breast cancer radiation spikes heart risk

Breaking chromosomes can lead to cancer, Tufts study says

In a study recently published in Molecular Cell, two molecular biologists at Tufts have used yeast artificial chromosomes to show that there is a highly flexible DNA sequence that increases fragility and stalls replication, causing the chromosome to break. The site that is prone to breaking lies in the middle of a tumor suppressor gene and breakage is highly associated with cancer.

According to Catherine Freudenreich, lead author on the study, "If you delete that gene or delete part of that gene so it doesn't work anymore, that can lead to tumors. The fact that there is fragility in the same region that this gene is located is a bad coincidence."

Boost vitamin C to fight cancer

A high intake of vitamin C has been shown to reduce the risks for virtually all forms of cancer, including leukemia, lymphoma, and lung, colorectal, and pancreatic cancers as well as sex hormone related cancers like breast, prostate, cervix, and ovarian cancers. Vitamin C is your body's first and most effective line of antioxidant protection. Vitamin C protects cell structures like DNA from damage and it helps the body deal with environmental pollution and toxic chemicals. Vitamin C enhances immune function, and it inhibits the formation of cancer causing compounds in the body (such as the nitrosamines, chemicals produced when the body digests processed meats containing nitrates).

Dr. Douglas Brodie states in the book, Alternative Medicine Definitive Guide to Cancer, "Each one of us produces several hundred thousand cancer cells every day of our lives. Whether we develop clinical cancer or not depends upon the ability of our immune systems to destroy these cancer cells. That's because cancer thrives in the presence of a deficient immune system."

Here is a list of foods high in vitamin C. Adding these foods to your daily diet will help boost your immune system which will aid you in fighting off many diseases as well as cancer.
Fruits and vegetables are both high in Vitamin C. The highest are papaya, raw red and green peppers, oranges, cantaloupe, broccoli, cauliflower, strawberries, Brussels sprouts, baked potato, cabbage, green peas, kiwi fruit, and kale.

There are a few good vitamin C supplements on the market but one that I particularly am using at present to super charge my immune system is Emergen-C Super Energy Booster which has 1,000mg of vitamin C along with vitamin B and 32 mineral complexes.

Anti-HIV drug use in pregnancy increases cancer risk

Antiretroviral drugs, used to prevent HIV transmission from mother to child, are now believed to cause genetic damage in infants. This damage, leading to an increased risk of developing cancer, makes it highly plausible these children may be diagnosed with the disease in mid and late adulthood.

Two new studies indicate there are cancer-causing effects of transplacental exposure to AZT, an antiretroviral drug. These effects -- like increased incidence of tumors and tumors with genetic changes -- have been demonstrated in mice and rats and seem to be cause for concern in humans too.

"The cumulative mutagenesis data suggest that infants exposed transplacentally to AZT may be at increased risk for cancer as they age," said one researcher, whose findings are published in Environment and Molecular Mutagenesis.

Mexican boy smuggled into United States dies of cancer

Eight-year-old Luis Carranza, whose mother slipped him from Mexico into the United States for live-saving cancer treatment, has died of leukemia after the same treatment that once offered him remission attacked his central nervous system, and caused seizures and terminal, irreversible brain damage.

Luis' story, first featured in a September 18 post, is a powerful one, riddled with struggle and hardship and love and commitment.

The story began less than two years ago when Guadalupe Carranza smuggled her young, sick son into the United States for treatment. Luis was welcomed into a Texas hospital and was showered with an abundance of love from staff and volunteers. Guadalupe did not receive the same warm welcome, however, and was deported back to Mexico. And while she battled to return to her son's bedside, Guadalupe was met with continued defeat -- until her son fell into a coma and border and consulate officials allowed the mother to cross back into the United States where she stayed until her son passed away on Thursday at his grandparent's house in El Paso.

Guadalupe had been with her son since May 8, 2006. And an attorney involved in Luis' case says he believes the boy, despite his serious condition, could sense his mother's presence. And everyone involved believes the boy, who was clearly suffering, is now in a much better place.

Watercress can fight cancer by preventing damage to DNA

New research has stated that eating a bowl of watercress, a salad leaf, can significantly reduce DNA damage to blood cells.

The report was published in the American Journal of Clinical Nutrition and it involved 30 men and 30 women, half of whom were smokers. They ate a small bag of prepared salad for eight weeks, in addition to their regular diet.

The results of the blood tests on the participants showed a 22.9 percent reduction in DNA damage to white blood cells. Damage to DNA is considered by experts to be an important trigger in the development of cancer.

The benefits of watercress were especially notable among smokers.

The research concluded "The results support the theory that consumption of watercress can be linked to a reduced risk of cancer via decreased damage to DNA and possible modulation of antioxidant status by increasing carotenoid concentrations."

So, I think next time instead of skipping over the watercress for the arugula I will grab both!

Mind games help clear fog left from chemotherapy

As evidence mounts, it's becoming more and more clear that chemo brain, a mental fogginess that can result from chemotherapy, is a real concern and not just a convenient excuse cancer patients use to explain away their flighty and forgetful tendencies. It seems the brain really can suffer cognitive damage from the poisonous drugs that fight off deadly cancer cells. And sometimes, this damage is present years after treatment.

Add to chemo brain the normal aging process as well as brain conditions such as mild cognitive impairment and even schizophrenia and the brain might not stand a chance of ever remembering anything. Unless we buy into the new concept of mental training -- somewhat like physical fitness training -- in which case we may be able to bring back a level of sharpness to our lives.

Research suggests this type of training may delay mental decline. And Betty Hall, 85, who is taking a brain fitness class at her senior living complex in Illinois, says brain-enhancing activities are definitely helping her.

Hall is participating in an eight-week program where she spends one hour per day, five days per week using a computer to match words and listen for details in stories. She says it's helping her remember where she places her keys and her grocery lists -- and it's even helping her in her bridge club.

"I've won four times out of the last five at bridge club, and I think the players are going to shoot me because I keep remembering the cards people have," she said. "It's much easier for me to concentrate . . . and I brag about it everywhere I go."

One clinical professor of neurology says brain health programs will explode over the next few years because of the stunning findings on this front. One study shows relatively short training regimens, lasting just five or six weeks, improve functioning for as long as five years. And booster sessions help advance these gains. Study participants says their everyday tasks, like managing finances, are much easier after mental workouts. Another study of the computer software Hall uses shows the program shaves an average 10 years off the mental age of users.

Not all mental training is alike, and different cognitive difficulties may call for different training protocols. But the simple fact that I can work out my brain like I can work out my body gives me hope that I can possibly reverse the effects of chemotherapy on my own foggy brain, that I can one day not worry anymore that I might find my check book in the refrigerator and my cell phone in my sock drawer. Bring on the workouts!


Thanks to Bev, my brainy friend, for this story tip!

CT scan radiation in excess for some child patients

It has just recently been discovered that CT scans for children have been inappropriately used in two Ontario hospitals. As a result, some children have received excessive doses of radiation, putting them at greater risk of developing cancer later in life.

Staff at the two hospitals -- Peterborough Regional Health Centre is one -- reported that in close to 50 percent of selected cases, the appropriate equipment settings were not used.

Herein lies the problem -- developing organs are more susceptible to damage, and giving a small child an adult dose of radiation in a CT scan delivers the same amount of radiation as 4,000 traditional X-rays. Research shows that increased exposure to radiation over time can cause radiation-induced cancer.

CT scans are valuable diagnostic tools because they create 3-D images of organs, offering a better view of head injuries, chest trauma, cancer, and fractures. So they should not be disregarded -- but clearly, hospitals need to improve the management of all scanning procedures.

In Ontario, a diagnostic image safety committee has already been formed. The goal of this committee is to develop standards and do a better job of tracking radiation levels.

Experts are encouraging Ontario parents to refrain from worry unless their children have received many CT scans. And all parents are encouraged to speak up before their children receive CT scans. "Is my child receiving a pediatric protocol?" is all it takes.

Unique characteristics of rapidly-growing melanoma

Not all melanomas are alike, and the characteristics of a fast-growing melanoma skin cancer begin in skin tumors that are thicker, symmetrical, elevated, have regular borders or have symptoms, according to the conclusions of a survey study completed by Peter MacCallum Cancer Center researchers. They also note that the faster-growing melanoma is more likely to affect men 70 years or older and individuals with fewer moles and freckles.

"In summary, this study provides descriptive data on the spectrum of melanoma rates of growth and insights into subgroups of patients with melanoma that are associated with rapid growth," stated the researchers. "We propose that this information on melanoma rate of growth be incorporated into education programs for patients and health professionals."

The advantage of identifying the more aggressive melanoma will allow for more aggressive treatment. Details of the study will be published in the December issue of Archives of Dermatology. Of the different skin cancers, melanoma is the most serious and most often appears as a change in size, shape, or color of a mole. To learn more about melanoma, visit the National Cancer Institute's melanoma section and The Cancer Blog's melanoma and skin cancer category of posts.

Olive oil's anti-cancer effects

When I make a salad or anything that needs oil, I always reach for the olive oil. It is regarded as a healthful dietary oil because of its high content of monounsaturated fat (mainly oleic acid) and polyphenols.

In a study to be published in the January 2007 issue of The FASEB Journal, scientists from five European countries describe how the anti-cancer effects of olive oil may account for the significant difference in cancer rates among Northern and Southern Europeans.

The researchers examined urine samples of subjects consuming a little less than a quarter cup of olive oil for three weeks. They were looking for specific compounds known to be waste by-products of oxidative damage to cells, a precursor to cancer. At the beginning of the trial the presence of these waste by-products was much higher in the Northern European subjects than their Southern European counterparts. By the end of three weeks of consuming the olive oil the presence of this compound in Northern European subjects was substantially reduced.

They also found that phenols in olive oil are not the only compounds that reduced oxidative damage. Phenols are a known antioxidant that is present in a wide range of foods, such as dark chocolate, red wine, tea, fruits and vegetables. Even if the level of phenols in the olive oil was reduced the study's subjects still received the same health benefits.

When you are cooking this holiday season, pick up some olive oil. I also use the spray olive oil which is great for getting those muffins out of the tray!

With age comes wisdom, with cancer comes love

Danny became aware of my port just before it was removed. He was only 18 months old when I was diagnosed with breast cancer, and my journey went pretty much unnoticed by this small boy who had no idea ports were not standard on every person he met. Now he is three years old and even though he still has no real idea why a port popped up from underneath my skin for two years, he did come to realize it was something akin to a boo-boo that one day goes away.

My port went away on September 15. And ever since that day, Danny has been very concerned about the incision that marks the spot once home to a foreign device. For one week after my port removal, my incision was covered. Danny wondered why. I told him I was healing, that I had to keep my boo-boo protected, that I could not take a shower because it could not get wet. Danny was very attentive. He pulled at the neck of my shirt every time I held him to sneak a peak at the site of my surgery. He asked if it hurt, if doctors cut me with a knife, if new skin was growing underneath my bandage. "Yes", "yes", and "yes." I told him. And one day when I decided to take a shower, despite orders to keep the area completely dry, Danny said, "The doctor said you cannot take a shower." I told him, "I know." And he said, "But actually you did take a shower." I told him he was right and hoped he would not pursue my disobedience any further. He did not -- he was just checking up on me, he was just concerned about me, he was just wondering if I may have compromised something. I told him I was fine.

I did not do any damage with my rebellious shower, my bandage is off, and Danny only peeks once in a while to monitor the area. He is mostly back to his normal life, free from all nursing duties. And I am mostly back to life, free from my port and happily showered in love by my littlest guy -- the guy who was once oblivious to all things cancer related, the guy who somehow became my caregiver.

Real sun tan in a bottle: plant extract changes skin pigmentation

Knowing the skin damage that results from prolonged sun exposure needed to achieve the golden tan, many fair-skinned people are staying out of the sun and turning to spray on or sunless lotion tans. These fake tans are skin dyes that do not change or darken skin pigmentation the way the sun might, but do give a temporary look of a glowing tan complexion. Advances have been made to these products so that the olden days of orange palms and streaky uneven lotion marks from sunless lotions are a mere memory, but still, it's not a real tan.

What if you could achieve a real tan, a tan where the skin pigmentation actually changes and darkens the same as it would if you spent hours in the sun, without spending hours in the sun exposing yourself to the premature aging, wrinkling and increased skin cancer risk damages of ultraviolet (UV) radiation?

In addition, what if this product, in actually darkening the pigmentation of your skin, provided protection from UV sun damage?

Although still in the experimental stages, scientists are working on just such a lotion, using a plant extract called forskolin, that prompts the pigmentation of the skin to darken. While the efforts are said to be focused on the treatment of individuals with medical pigmentation disorders -- if forskolin proves safe -- could a commercial product using the same compounds that safely promote a darkening of skin pigmentation -- a real tan -- and skin cancer prevention -- be far behind?

Mother bravely battles border for son battling leukemia

Luis Carranza is just eight years old. And he is just a few years -- or perhaps a few months -- away from dying as a result of a weakened immune system due to aggressive treatment for leukemia. The same treatment that at one time brought remission for this boy also attacked his central nervous system, caused seizures, brought on terminal and irreversible brain damage, and eventually sent him into a vegetative state. Luis has traveled a rough road -- and so has his mother who illegally slipped him across the Mexican border into the United States in hopes of treatment to save her young son's life.

Guadalupe Carranza did find salvation for her son in a Texas hospital and for more than one year, Luis received chemotherapy and radiation -- and loads of love from staff and volunteers who helped care for him. Guadalupe was not always there for her son, though, because after locating helpful health care and social services, she was deported to Mexico. She tried to return on many occasions and even received assistance from doctors, nurses, social workers, and attorneys who worked to find a legal way to unite Guadalupe and Luis. But not until Luis fell into a coma did efforts pay off.

After negotiation with border and consulate officials, Guadalupe was granted a humanitarian parole visa and legally crossed into the United States on May 8. The visa allowed her 60 days -- but officials agreed to let her stay until Luis passes away. And so she stays -- by her son's bedside where he rests peacefully in a place that gave him a chance at life. A chance his mother says he never would have had in Mexico.

Potato chips may be next hazardous food to cut from diet

I have never completely cut a certain food from my diet just because of speculation that it may cause cancer. Because I eat most everything in moderation, I have felt that anything I am ingesting is too small an amount to make any real difference. I have heard recommendations about nixing preserved foods and anything treated with hormones and refined sugar and while I try to eat a balanced, healthy diet -- with a bit of sweet stuff thrown in -- I do sometimes indulge my cravings for foods that are not very healthy. Like chips -- which writer Robert L. Wolke says he is definitely eliminating from his diet.

The chemical acrylamide -- a probable carcinogen -- has been found in fried starchy foods, especially potato chips and French fries. This chemical is not a contaminant that somehow appears in our food but is created by chemical reactions that take place during cooking at high temperatures. It's a chemical that has been used in industry and has been known to damage the central nervous system, the immune system, and the reproductive system. And it may cause cancer. Recently, acrylamide was discovered in foods at hundreds of times the .5-parts-per-billion level that is considered safe in drinking water.

Authorities in Germany have already begun enforcing regulations to minimize the amounts of acrylamide in foods. But the United States has been criticized for dragging its feet on this issue. In fact, the National Uniformity for Food Act (H.R. 4167) recently passed the U.S. House of Representatives, with 94 percent of Republicans supporting it and 64 percent of Democrats opposing. It has gone to the Senate, where it was the subject of a hearing on July 27. The act would prohibit states or local governments from setting more stringent limits on toxic substances.

Each of us can still take personal action with regard to the foods we eat -- despite what the government dictates. We can decide what to eat and what not to eat. In the interest of our health. And our future.

For information on acrylamide levels in hundreds of different foods, click here.

Sunscreen can protect or damage skin

Sunscreen, designed to protect the user from sun skin damage might actually cause sun skin damage if applied incorrectly and infrequently. University of California Riverside chemists examined the effects of sunscreen lotion on the skin and found that after a period of time, the lotion or cream is absorbed into deeper layers of the skin. If more sunscreen is not applied to block ultraviolet radiation (UV), the sunscreen that has been absorbed into the deeper layers of skin creates additional oxidative damage as UV rays are able to penetrate through to the deeper layers where the sunscreen has been absorbed. When sunscreen is applied often, this does not happen.

There is only one practical solution at this time and that is to apply sunscreen lotion or cream often, about every two hours or after sweating or swimming. Researchers suggest another potential solution would be for sunscreen makers to mix sunscreen with antioxidants because antioxidants have been shown to reduce UV-induced damage to the skin. UC has published an in-depth explanation with photos of effects to the skin following the sunscreen experiments here.

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