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Posts with tag deadliest

Thought for the Day: Headed for melanoma

Oh no. I think I 'm headed for melanoma. At the very least, I seem to have a very high risk for developing the disease, thanks to my once-stubborn pursuit of a silly tan.

Think about this:

A review of seven different studies concludes that using a tanning bed under the age of 35 -- I'm so guilty -- can increase the risk of melanoma by 75 percent. Even those who have ever used indoor tanning were 15 percent more likely to develop the disease.

We're talking the deadliest form of skin cancer here. So deadly some experts are recommending strong measures to restrict the use of tanning beds by young people. Adults should be discouraged from tanning, some say, but access should be limited for those under the age of 18.

New Jersey already has regulations in place -- those under 14 are banned from tanning salons and anyone between 14 and 18 must have parental consent.


If I could turn back time, I would listen to my grandma. She told me the sun -- and tanning beds too -- were no good. But I was young. And I didn't care.

Now I'm older. And I care. But it may be too late. It seems this could be one lesson I learn the hard way.

Marcia Cross chosen as Olay skin cancer prevention partner

Skin cancer awareness month doesn't arrive until May, but Olay and the American Society for Dermatologic Surgery have already chosen their spokesperson for the 2007 Skin Cancer Takes Friends campaign.

Emmy-nominated Desperate Housewives actress Marcia Cross will kick off a nationwide free skin cancer screening and education initiative to alert Americans about the importance of early detection and prevention in the fight against a disease that has affected her personally.

"I'm proud to be part of a cause that is near and dear to my heart," says Cross. "Having had two family members suffer from melanoma, I've come to understand the importance of skin cancer detection and prevention. Knowing what I know about the dangers of sun exposure, I take extra care to protect myself with a large hat, sunglasses, daily UV protection, and of course, an annual screening."

Cross has become an partner in the crusade against skin cancer so she can encourage people to protect not only themselves but their family members and friends too.

Beginning on April 1, log onto skincancertakesfriends.org to find a dermatologist offering free screenings in your area. Take a friend with you to your screening during the months of May, June, and July and each of you will pay not a penny.

Many people don't know just how dangerous skin cancer can be. Yet it's the most common form of cancer in the United States and the incidence of melanoma -- the deadliest form of the disease -- is rising faster than any other cancer. Right now, one in five Americans will develop skin cancer during their lifetimes. And every 67 minutes, someone dies of melanoma.

Screening is a must for everyone -- regardless of skin color, ethnicity, age, or geography. So mark your calendar for April 1 if you'd like a free screening. If money is not an issue, make an appointment today.

Researchers search for root of pancreatic cancer stem cells

Researchers have made a stem cell discovery that may help treat pancreatic cancer -- one of the deadliest forms of the disease.

University of Michigan scientists have found cancer stem cells in pancreatic tumors that appear to drive cell tumor growth and could lead to the development of drugs to target and kill these cells.

Pancreatic cancer kills 97 percent of people diagnosed with the disease within five years. Half of all diagnosed patients die within six months of diagnosis, and this cancer -- that spreads quickly and is rarely detected at an early state -- kills 33,000 each year in the United States alone. So any improvement in the study of this disease is a true gift.

"The clinical implications of this work are significant," said Dr. Diane Simeone, director of the Gastrointestinal Oncology Program at the University of Michigan Comprehensive Cancer Centre and lead author of the study, published in the journal Cancer Research.

"We've made baby steps in improving the survival in these patients -- on the order of a few months (longer to live) -- over the past decade or so. But we really haven't had a major breakthrough in coming up with something that has the potential to provide a cure," she said.

Simeone says killing these cancer stem cells is like pulling out the root of a weed. And she says the best way to pull out the root is to target these stem cells instead of the traditional approach of shrinking tumors by killing as many cells as possible -- an approach that may be flawed because cancer stem cells tend to resist standard therapies.

Drug slows return of pancreatic cancer

Pancreatic cancer is one of the deadliest forms of cancer. So any bit of progress on the pancreatic cancer front is a big deal. And researchers are happy to report they've found a chemotherapy drug that can help patients who have received surgery prevent a return of the disease for a longer period of time.

In a German study, participants who received Gemzar, or gemcitabine, lived an average of 13.4 months without their cancers coming back. Participants who did not receive the drug lived without the disease for 6.9 months. While the findings of this study may seem modest, they really are quite encouraging because pancreatic cancer is such a rapid killer, and patients with this disease have the worst chances of recovery.

This study, published in Wednesday's Journal of the American Medical Association, brings hope for the mere 20 percent of pancreatic cancer patients who are candidates for surgery. While surgery is the best hope for a cure, the disease still returns in the majority of cases -- so Gemzar is surely worth a shot.

It should be noted that some study authors report financial ties to Gemzar drugmaker Eli Lilly and Co. Researchers, however, report the firm had no influence in design or data interpretation.

Family helps identify gene linked to pancreatic cancer

A decade of research specific to the inherited form of pancreatic cancer has turned up a gene that could lead to earlier diagnosis and treatment for one of the deadliest forms of cancer.

The magical gene -- called palladin -- was discovered at the University of Washington after the extensive study of one family that has lost nine members over four generations to pancreatic cancer and has nine additional members with early signs of the disease.

Washington resident Ryan Chappell, a member of this family who had his pancreas removed just before cancer could strike, is very excited about this breakthrough.

"I feel really good that my family has not suffered (in vain)," the 21-year-old says. "Something has been accomplished from their contribution."

What the Chappell family has contributed to research is an understanding of a breakdown in a gene that makes a protein for the skeleton of pancreas cells. In this one family, the gene was mutated and produced large amounts of a misshapen protein that rolls like tumbleweed through the body, migrating 50 percent faster than other cells.

Scientists hope to translate their research findings into a diagnostic test to find excess amounts of the protein and to prevent the cancer cells from moving.

For now, early detection of pancreatic cancer rare because the pancreas is deep in the body, making it difficult to feel or see tumors through imaging tests. Symptoms -- like jaundice, abdominal and back pain, and digestive problems -- usually surface only after the cancer has spread.

Cancer of the pancreas is rare but is the third-leading cause of cancer death among people age 40 to 60.

Uncovering clues to brain cancer

Glioblastoma is the deadliest form of brain cancer, most often striking patients in their 50s and 60s who after diagnosis typically have only 10 to 12 months to live.

Glioblastoma is a shocking diagnosis -- and while the tumors don't tend to spread outside the brain, they resist surgery and return even when half the brain is removed. They also are resistant to most treatment. Clearly, insight into this deadly cancer is a must. Thankfully, a little slice of insight has just emerged.

Armed with findings from experiments in mice, researchers report they've discovered a clue that might help unravel the mystery of glioblastomas.

Studies show that some mice recovered from a human form of brain cancer when given bone morphogenetic proteins that appeared to interfere with the cancer growth process in stem-like cells. This leads researchers to believe the proteins could be used to stop cancer growth and prevent it from recurring.

The research is not ready for prime time, says one of the researchers who maintains there is still a long way to go. Yet the findings are promising -- and they suggest stem cells may play a critical role in tumor formation.

About 17,000 to 18,000 Americans develop brain cancer each year. Half of these patients will be diagnosed with glioblastoma.

Cutting edge technology emerges for skin cancer diagnosis

In the not-too-distant future, dermatologists will be able to diagnose skin cancer without ever cutting the skin.

Right now, doctors cut out all suspicious lesions in order to examine them, to determine if they are cancerous or not. But with the development of a new microscope, cells can be examined right on the body -- without cutting.

Moles matter, reported Matt Lauer on Thursday's TODAY show during an interview with a skin cancer expert. Moles are highly associated with melanoma, the deadliest form of skin cancer. So it is critical that each mole is investigated. With this new high resolution technology -- essentially a video biopsy -- a camera will allow doctors to view cells, zero in on the area of concern, and pinpoint the exact cells that make up a mole. If the cells are similar in shape and size and have equal distribution, the mole is normal. If the individual cells are irregular and have no uniform pattern, the mole is abnormal and probably cancerous.

While cutting for biopsy purposes will one day be a thing of the past, cutting will still be necessary if a mole is characterized by cancerous cells. If it's cancer, it must come out. But the video biopsy can be used to map the border and boundaries and will allow for precise removal of the mole.

This technology is still developing -- but one day, perhaps eight to 10 years from now -- doctors will be able to more consistently detect cancer without removal of skin. For now, they must take a piece of the mole and put it under a microscope.

There are definite warning signs of skin cancer. Any mole that is asymmetrical with irregular borders and varied, dark colors should be reported to a physician. Also, any mole that changes in color, shape, or size and is bigger than a pencil eraser is cause for concern.

Cancer prevention homework: study ABCDs of melanoma

I am an expert in the game of what-if. I guess it's because my recent what if this hard lump in my breast is cancer worry turned into Oh My God, it is cancer that I am so polished at this exercise in all things irrational. Sure, some worries will be fulfilled by reality but for the most part, things turn out okay. But still, I worry. When a bone hurt in my arm last year, I was sure it was bone cancer. It wasn't. When I felt a soft bump on the roof of my mouth, I whisked myself to the dentist for my mouth cancer diagnosis. It was just a little bit of inflammation, probably from a cold. A headache landed me in a tube for a scan of my head. It revealed nothing interesting, and ibuprofen fixed me right up. And lately, I am checking every mole, freckle, spot, speck, and discoloration that adorns my fair skin.

I asked about each of these what-if marks yesterday at my annual skin cancer screening. Surprise -- nothing is wrong with me. But all unfounded fears aside, there is some method to my madness about skin cancer because I have had several bad burns in my life, have spent too many hours in the sun in search of a tan, and have already had a few pre-cancerous spots removed from my skin. So I do plan to monitor my skin -- just maybe not every day -- for the ABCDs of melanoma. And you should too -- because melanoma is the deadliest of skin cancers, and it is known for spreading, which makes treatment essential. So consider these what-ifs when screening yourself for skin cancer.

What if a spot on my skin is Asymmetrical? This means that one half of the mark on your skin does not match the other half. See your dermatologist.

What if the Border of the spot is irregular? This means that the edges are ragged, notched, or blurred. See your dermatologist.

What if the Color of the spot is not uniform? This means that shades of tan, brown, and black are present. Dashes of red, white, and blue add to the mottled appearance. See your dermatologist.

What if the Diameter is more than 6 millimeters? This is about the size of a pencil eraser. Any growth of any mole should also be of concern. See your dermatologist.

It is estimated that 44,000 Americans will develop melanoma annually. Of these people, 7,300 will die. But the death rate is declining -- because patients are seeking help earlier. Perhaps the ABCDs of melanoma are helping. I hope they help you -- and me too.

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