UK researchers have developed a 3D laboratory model of human breast cancer, specifically ductal carcinoma in situ (DCIS). The model, complete with normal cells and tumor cells, should help experts understand how the disease develops in its early stages, and it could replace the need for experiments in animals.About one in five breast cancers in the UK start out as DCIS. Researchers wanted to learn more about how the early cancerous changes in cells develop into larger tumors, and they chose to fashion a 3D test tube model because it is more complex than a layer of cells in a Petri dish.
Once this experiment is proved successful, it could reduce and perhaps replace animal studies.
"With breast cancer, there is an urgent need to move away from animal research models because their similarity to human cancer can be so poor," says one expert who explains this model could help revolutionize breast cancer research -- because unreliable research costs time, money, and lives, both animal and human lives.


Chloe is a little girl conceived through in vitro fertilization -- not because her parents could not conceive in the traditional manner but because they wanted to make sure Chloe had no predisposition to cancer in her genetic makeup. And in vitro fertilization is one method of almost ensuring this. There is still a three percent chance of failure but Chloe's parents felt confident in the elective process that would mostly prevent her from inheriting a genetic mutation for colon cancer that has devastated her family -- Chloe's father carries this mutation, and his mother, grandfather, and two uncles have all died from colon cancer.







