Canadian researcher Evangelos Michelakis, associate professor of medicine at the University of Alberta in Edmonton, has stumbled upon something quite remarkable -- a potentially new anti-cancer agent called dichloroacetate, or DCA.

DCA is nothing new -- it's long been used for treatment of rare metabolic disorders -- but using it to fight cancer puts an entirely new spin on the potential of this drug.

"This is one of the most exciting results I've ever had," Michelakis said. "But I can't be overenthusiastic until it works on a human."

Michelakis and his colleagues have successfully used DCA to shrink human lung, breast, and brain tumors in both lab rats and test tubes. And while this type of research may not ordinarily generate a lot of excitement, this specific study is creating a buzz because DCA has been safely used in humans for decades, without adverse side effects.

"One of the big concerns about drugs is that they can harm people but we already know this drug is safe," Michelakis says. "It doesn't even affect normal cells."

One of the fundamental premises of cancer biology is that mitochondria -- the energy producing units of cells -- are permanently damaged by cancer. What DCA does is revive the mitochondrial function, encouraging the death of cancer cells.

The overwhelming hope is that DCA will move right to human testing. But the overwhelming fear is that it will not -- because of economic reasons. There is no longer a patent on DCA so it is not owned by any one company. With little chance of one group making a large profit, there may be no incentive for pharmaceutical companies to invest in research.

Sadly, this drug -- that appears to work remarkably well -- may never benefit cancer patients. All because no one stands to make billions of dollars from it.

Cervical cancer was once the most common cancer in women. But between 1955 and 1992, the number of cervical cancer deaths dropped by 74 percent -- thanks to increased use of the Pap test, a screening tool that can find changes in the cervix before cancer develops and can also detect cancer in its most curable stage. The Pap test is still widely used. And the cervical cancer death rate continues to drop four percent every year.

In 2006, about 9,700 new cases of invasive cervical cancer will be diagnosed in the United States. About 3,700 women will die from the disease. Non-invasive cervical cancer is believed to be four times more common than the invasive form of the disease. Nearly all of these cases can be cured.

Cervical cancer typically occurs in women between the ages of 35 and 55 and rarely in women under the age of 20. It affects mostly Hispanic women, and African-American women develop the disease 50 percent more often than non-Hispanic white women. Women most as risk for cervical cancer are smokers, those with HIV or chlamydia infections, those with diets low in fruit and vegetable consumption, those who between 1940 and 1971 took the hormonal drug DES, and those who have taken oral contraceptives for extended periods of time. Women who have had multiple pregnancies, have a family history of the disease, and have a low socio-economic status are also at risk. Those most at risk, however, are women with human papilloma virus.

Human papilloma virus (HPV) is the most common risk factor for cervical cancer, and some experts believe a woman must have HPV to contract cervical cancer. There are 100 different types of HPV, 13 of which are likely to cause cervical cancer through sexual contact. There are usually no symptoms of HPV, but possible signs of cervical cancer can include vaginal bleeding, unusual discharge, pelvic pain, and pain during sexual intercourse.

There are two ways to stop cervical cancer. First, women can protect themselves against HPV. Protection comes in the form of delaying sexual activity, limiting the amount of sexual partners and their partners, using condoms (thought to be 70 percent effective) and receiving the cervical cancer vaccine, recommended for use in females ages 11-26. The vaccine is most effective for women who have never been sexually active. Second, women can receive regular Pap tests in order to catch pre-cancers. Pap tests are recommended for women three years after their first sexual encounter and before the age of 21 -- and then every year after that.

An abnormal Pap test typically prompts a colposcopy -- a technique that uses a scope to examine the cervix. Diagnosis usually stems from a combination of other scoping methods, pelvic exams, imaging tests, and biopsies used to confirm the presence of cancer and to stage the disease. Stages range from 0-4.

For non-invasive cervical cancer, surgery -- ranging from removal of the cancerous tissue to hysterectomy -- may be the only treatment necessary. For invasive forms of the cancer, surgery is often followed by radiation and chemotherapy. Women interested in preserving their fertility should discuss options with their physicians.

The state of cervical cancer has come a long way over the years. And this year, two critical developments emerged. In June 2006, the FDA approved the first drug for late-stage cervical cancer. The drug, Hycamtin, is recommended for use in combination with chemotherapy. Also is June, the cervical cancer vaccine, Gardasil, was released. Both developments are monumental -- and both will undoubtedly help decrease the already-dropping cervical cancer death rate.

For more information about cervical cancer, visit the following sites:

American Cancer Society
Mayo Clinic
Medline Plus
National Women's Health Information Center

In the 11th report of the Committee on Medical Aspects of Radiation in the Environment (COMARE), children growing up in an affluent urban environment and children from rural areas are at higher risk for developing many cancers.

Researchers studied cancer clusters where leukemia and other childhood cancers were reported, and have come to the conclusion that affluent children are being raised in an environment that is too clean. Called the dirty hypothesis, children living in too sterile an environment where they are not exposed to infection have weak immune systems.

For rural children, infection brought in to the rural community by people from larger populated urban areas, might be causing genetic damage that leads to cancer.

With the exception of the processing plant at Sellafield in Cumbria, and Dounreay in Scotland, the researchers also state they found no general pattern of increased cancer incidence around nuclear plants.

The researchers feel confident in the reported results of this study. They invite further study into the hypothesis of their findings. The database was constructed from the National Registry of Childhood Tumours by staff of the Childhood Cancer Research Group in Oxford, and included 12,415 cases of childhood leukemia and non-Hodgkin lymphoma and 19,908 cases of children with solid tumors registered under the age of 15 in England, Wales and Scotland from 1969 to 1993. To download the 160 page report, go here.

The costs of medical care are skyrocketing. Governments are grappling with the rising costs in how to provide healthcare and cancer patients are struggling to get the care they need. Where is the unfolding national and global healthcare crisis headed and what will our healthcare look like in the future?

According to the World Bank, the healthcare gap between rich and poor countries remains steady and warns the trend is likely to continue without some type of fundamental change in how we care for people in less-prosperous countries. Jean-Louis Sarbib, vice president for the World Bank's division that produced the new report, is quoted as saying, "This inequity has tremendous consequences for the health of the world's poor." It is predicted that the world's population is expected to grow from 6 billion today to a projected 7.5 billion by 2020, with most of the growth expected to be in developing countries.

Two topics of conversation sure to make people uncomfortable are obesity and poverty. But both are necessary to conversation about cancer prevention because both increase the risk of cancer and death from cancer. Obesity is a cancer concern because being overweight is linked to an increase for some cancers. Obesity often reflects a nutrition-deficient fat-laden diet and a physically-inactive lifestyle that increase the risks for cancer. This is why the topic of obesity is so important to cancer prevention. Poverty often prevents people from seeking medical care because they cannot afford to see a doctor or undergo early cancer screening tests or cancer treatments once diagnosed with cancer. Researchers and organizations are beginning to devote more time and money into understanding the problem and in finding the solution to the rising obesity epidemic. No where is it more important than in the lives of our children.

Louis Rukeyser, host of the television program Wall Street Week With Louis Rukeyser, passed away yesterday after a long struggle with multiple myeloma, a rare bone marrow cancer. A financial journalist known for his dry wit and common sense jargon-less approach to financial matters, he gained an enormous following of loyal fans over the years. Rukeyser demystified the economic and financial world for millions as a television show host, columnist and author. PEOPLE described him as the only sex symbol of the dismal science of his field. Louis Rukeyser died peacefully at home in Greenwich, Connecticut. He was 73.