Cancer of the unknown primary is when cancer is found somewhere in the body but the pathologist is unable to tell where the cells originated from. The cancer cells are so poorly differentiated that they do not resemble any cells of the body. It can be very difficult to find the right treatment because doctors usually use the type of cancer as the main starting point to choose chemotherapy or treatments that are known to be effective. Other problems arise with this type of diagnoses. Many physicians do not have much to go on to treat this disease or know if the patient is likely to survive.

French researchers have developed a prognostic model for cancer of the unknown primary. The findings were published in the December 1st issue of Cancer. Low serum albumin levels and elevated serum lactate dehydrogenase (LDH) in the blood of patients had the worse prognosis overall. This prognostic model can show who has the most powerful adverse prognostic factors.

Even with this information though, it doesn't seem to have anything to do with treatment. They can tell who has a better or worse prognosis but what then?

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Cancer of the unknown primary

Heartburn has never really been considered a major health concern. It has been considered uncomfortable and annoying and troublesome -- yet still only a harmless nuisance. In recent studies, though -- summed up in the September 2006 Oprah magazine -- heartburn has been linked to a deadly form of esophageal cancer. Apparently, people who experience heartburn one time per week or more have a fivefold or greater risk of adenocarcinoma of the esophagus -- a cancer with incidences jumping as much as 500 percent over the past 40 years. Experts insist, however, that adenocarcinoma is still rare. One doctor states that 40 percent of Americans have heartburn once per month -- yet only 8,000 to 9,000 people develop this specific cancer each year.

For the unfortunate few who do go on to contract cancer, there is hope in a surgical procedure to remove the cancer and part or all of the esophagus and nearby lymph nodes -- which can dramatically increase the odds for survival. For most of us, a bit of heartburn does not signal an eventual cancer diagnosis. It just means we might need to self-treat the symptoms with over-the-counter remedies. And a recent review at Stanford suggests that sleeping with your head elevated can reduce reflux pain.

You should see a doctor if your heartburn results in a consistent burning sensation, difficulty swallowing, or vomiting.