She's cute and spunky and full of life. She's Miss Melanoma, and her mission is simple: to raise awareness about skin cancer. Her slogan -- Attitude is everything. You're living with melanoma, not dying from it -- sums up this survivor girl, also known as Lori Lee, whose main goal is to get a Surgeon General's warning in every tanning bed salon window.

Think about this:

Miss Melanoma has a website. It's a spot for readers to learn, explore, RANT, even curse at cancer. "We won't censor your thoughts," she writes. "And we promise someone here will get exactly what you're saying."

The site features news, articles, artwork, shopping, and Miss Melanoma's personal blog, which is simply captivating. And quite shocking too.

Miss Melanoma, who learned in 2005 that a mole on her right foot was the absolute worst form of skin cancer, has endured the amputation of part of this same foot and aggressive treatment for a disease that began spreading up her leg and into her lymph nodes. And now, right now, Lori Lee is awaiting news from her surgeon about whether or not a likely cancerous lymph node deep in her pelvis can be surgically removed.

"Is it weird what a relief it is to be fighting cancer again?" she blogs. "It's something only a cancer survivor can understand, I think. You just don't know until you've been there. It's the new abnormal, people. Sitting around waiting for it to return when every doc you see tells you it's most likely coming back will drive you up the walls. Knowing that it's here and it's really just one lymph node and that we can treat it, that's a relief. I know. I can't explain it."

I urge you to think some more about Miss Melanoma, visit her website, her blog, and even send her your warm wishes as she continues living -- not dying -- from cancer.

If the experimental breast cancer drug Tykerb continues to prove successful in study participants, it could be headed for FDA approval.

Tykerb, now in international study, showed in early studies to be even more effective and to have fewer side effects than similar breast cancer drug Herceptin. Both drugs are part of a cluster of targeted therapies that attack cancer cells while sparing healthy cells. Designed for use on women whose breast cancer is HER2 positive -- meaning it contains too much of an aggressive protein -- Tykerb may be a wonder drug, with the capability of effectively keeping breast cancer at bay.

Dr. Paul Goss of MA General Hospital says, "We're seeing Tykerb, which is a pill, which is easier to take, has a broader attack and gets inside cells. It's like an electrical circuit that's turned on, and Tykerb can pull the lever, the circuit breaker, and switch it off."

Soap opera actress Darlene Conley, best known for playing Sally Spectra for the past 20 years on The Bold and the Beautiful, lost her battle with cancer over the weekend. She was 72.

Conley, who was diagnosed with stomach cancer just three months ago, also played characters on Days of our Lives and General Hospital -- and many knew her as black market baby broker Rose DeVille onThe Young and the Restless.

Before embarking on a daytime career, Conley made appearances in movies The Birds and Valley of the Dolls and on television shows such as Murder, She Wrote, Cagney & Lacey, and The Mary Tyler Moore Show.

Dr. Len Lichtenfeld, MD, is the deputy chief medical officer for the American Cancer Society. He is also a blogger and authors his very own blog -- called Dr. Len's Cancer Blog.

Dr. Len writes on his blog about all sorts of topics related to cancer. He shares his opinion on the recent drop in breast cancer cases (December 15, 2006), he promotes the Great American Smokeout (November 14, 2006), he sounds off on lung cancer screenings (October 25, 2006), and he urges parents to always slather sunscreen on their children (October 5, 2006). He has so much more to say -- and his blog is a great stop for those wishing for more information on hot cancer topics.

As this year comes to a close, Dr. Len offers a review of what he believes were the hottest cancer topics of 2006.

Dr. Len reflects in his blog about decreased cancer death rates that represent real progress in the fight against cancer. He calls the HPV vaccine a breakthrough and he recaps the STAR trial -- a comparison of raloxifene to tamoxifen to reduce the risk of recurrent breast cancer in post-menopausal women -- with emphasis on how raloxifene proved just as effective as tamoxifen, but with a better safety profile. He calls new targeted therapies a dream -- with a hefty price tag -- sure to garner debate and discussion in 2007.

Dr. Len reviews the Surgeon General's report on second-hand smoke -- it's harmful to non-smokers, the report says -- and he marvels at the capability of science to approach an understanding of what makes a cancer cell a cancer cell. He also remarks on how remarkable it is that chronic myelogenous leukemia is in fact chronic and no longer fatal, thanks to the drug Gleevec.

Of course, there is ample attention given to the declining incidence of breast cancer, reportedly due to less women using hormone replacement therapy, and the risks weighing on those who are overweight and obese, and survivors and supporters who gathered for Celebration on the Hill -- the site of one incredible American Cancer Society event.

Dr. Len closes his review of 2006 with recognition of three celebrities who lost their lives this year to cancer -- Dana Reeve, Ann Richards, and Ed Bradley. And while he recognizes there are other lives and other stories that deserve mention, there is simply not enough time or space for him to do justice to every noteworthy item.

"What we have seen over the past year is an incredible leap forward in cancer research, diagnosis and treatment, and I suspect there are going to be even more exciting developments in the coming year," says Dr. Len who looks forward to 2007 -- a year that is sure to deliver more hope and more progress in the fight against cancer.

Americans are urged to know their family medical histories -- and to share them with their doctors.

Spearheaded by the U.S. surgeon general's office and other public and private agencies, this urging is critical -- because knowledge of family history can lead to more frequent and earlier screenings for particular cancers, to changes in diet and exercise to combat onset of heart disease and diabetes, to more formal genetic counseling and testing if warranted.

This Thanksgiving marked the third anniversary of Thanksgiving National Family History Day, a day the surgeon general's office has reserved for family discussion and documentation of medical histories.

"Family history itself is the first and best genetic test," says Sharon Terry, president of Genetic Alliance, a non-profit group in Washington, D.C.

Brigham and Women's Hospital in Boston has started a work-place initiative regarding medical family history. In the past year, about half of the 13,000 employees -- from physicians to file clerks -- have completed the computerized family history forms developed by the surgeon general's office.

Acting surgeon general Kenneth Moritsugu says, "knowing your family history can help you make better health choices. Much of what we do in American health care is treat chronic diseases, many of which involve choices over a lifetime."

Each month, about 22,000 women log on to the National Cancer Institute (NCI) web site and answer seven questions to determine their risk of developing invasive breast cancer. The Gail Model, named for the NCI's chief biostatistician, Mitchell H. Gail, generates a five-year risk and a lifetime risk for each woman who answers each of these seven questions.

• Does the woman have a medical history of any breast cancer or of any ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS)? Note: This assessment tool cannot accurately predict risk for a woman who already has a medical history of breast cancer.
  
• What is the woman's age? Note: This tool only calculates risk for women ages 35 and older.
  
• What was the woman's age at the time of her first menstrual period?
  
• What was the woman's age at the time of her first live birth of a child?
  
• How many of the woman's first-degree relatives -- mother, sisters, daughters -- have had breast cancer?
  
• Has the woman ever had a breast biopsy? How many breast biopsies has the woman had? Has the woman had at least one breast biopsy with atypical hyperplasia?
• What is the woman's race/ethnicity?

A simple drop-down answer menu is provided for each question, and explanations for each question are available. Upon completion of the short survey, the Gail Model spits out a five-year breast cancer risk and a lifetime breast cancer risk with comparisons to the general population of women.

While this is only an assessment -- based on statistics that do not always take into account individual differences -- it is still a helpful tool. Because it's clear that women can minimize breast cancer risk with behavior changes and sometimes medication. And generating a personal rating on risk is a rating worth knowing. It's also worth knowing that this tool was designed for use by health professionals. If you are not a health professional, consider discussing your results with your doctor.

Michael Fumento is an author, journalist, and attorney specializing in science and health issues. And he has a lot to say about the Surgeon General's recent announcement that the second-hand smoke debate is over -- that second-hand smoke does in fact kill. Fumento believes that the debate is over means if you have your doubts, then keep them to yourself -- that the topic is not up for discussion any longer. But Fumento states that we should definitely have doubts -- about the effects of second-hand smoke and about what the Surgeon General has to say about it.