The U.S. Food and Drug Administration (FDA) has announced a new warning labeling change regarding bevacizumab (Avastin) a cancer drug currently in use to treat colorectal cancer, that state an increased risk for a brain-bleeding condition and potential nasal septum perforation that can create a hole in the nose for those patients being treated with Avastin. The rare brain-capillary leak can trigger headache, seizure, blindness and other vision and neurological problems.

The FDA has published a letter sent by Genentec to healthcare providers notifying them of the new warnings, available as a pdf document.

In the meantime, Avastin's drug maker Genentech has asked for FDA approval for the drug in the treatment of advanced lung cancer and breast cancer.

A ninth Hole in the Wall camp is in the works -- thanks to actor Paul Newman who started the first camp for critically-ill children in Connecticut in 1988. Hole in the Wall camps host thousands of children for free and are now scattered all over the map -- in California, New York, France, and other locations. And one will soon open in Israel.

Each Hole in the Wall camp is a separate entity with its own distinct personality and name -- like The Victory Junction Gang in Randleman, NC and Camp Boggy Creek in Eustis, Florida. All camps share a common goal of building self-esteem and restoring joy in the lives of seriously-ill kids. And typical camp activities -- for kids whose diagnoses range from cancer to muscular dystrophy -- include rope climbing, face painting, horseback riding, swimming, and sports. It's a typical camp where children can enjoy childhood, without compromising their medical needs, due to state-of-the-art medical care.

Newman makes periodic visits to the camps and only partially funds the camps that mostly survive on their own through charitable contributions. He clearly loves the camps that have served more than 100,000 kids from 34 states and 31 countries and says he wants the camps to be the legacy he one day is remembered for. And what a legacy it will be.