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Posts with tag houston

Thought for the Day: Stopping cancer in its tracks

It might not be possible at this time to eradicate cancer altogether. But we may be able to stop cancer cells in their tracks through a process called senescence.

In senescence, cells don't divide. And when cells don't divide, they don't grow. In such a scenario then, cancer cells wouldn't divide and therefore couldn't grow.

Think about this:

According to lab tests on mice, triggering senescence in certain cells hampers the growth of some tumors.

Researchers at the University of Texas M.D. Anderson Cancer Center in Houston are the ones behind the scenes on this project -- the study appears online in
EMBO Reports, a publication of the European Molecular Biology Organization -- and all eyes are on the p53 gene.

The p53 gene lives within cells and works to nip cancer in the bud by springing to action in damaged cells that may be spinning themselves into a cancer frenzy.

Researchers say senescence ordered by the p53 gene is extremely important in suppressing tumor formation and is as important as apoptosis -- a type of programmed cell death. But in some cancers, senescence might not be enough to halt cancer, they found.

OK, so senescence is not a perfect approach to halting all cancers. But it seems to work for some -- so I say for now, let's take what we can get.

More risk factors added to breast cancer list

Simply being female puts all women at risk for breast cancer. That and age, race, family history, personal history, genetic make-up, when they had children, when they reach menopause, and a whole host of other possible factors.

Now U.S. doctors are officially calling body mass index, breast density, and alcohol consumption predictors of the disease, says Therese Bevers, medical director of the Cancer Prevention Center, at the University of Texas M.D. Anderson Cancer Center in Houston.

Bevers helped write updated guidelines for the prevention of breast cancer and presented them at the 12th annual National Comprehensive Cancer Network in Hollywood, Florida on Friday.

The guidelines, featuring the revised list of risk factors, also offer treatment options for women -- including bilateral mastectomy for women who have tested positive for the genes BRCA1 and BRCA2 as well as possible medical treatments with drugs such as tamoxifen and raloxifene.

Different perspective on drop in breast cancer cases

There may be another explanation for the recently announced decline in breast cancer rates. And it's not nearly as promising as the first explanation may be.

A day after researchers announced that the significant drop in breast cancer cases is primarily due to fewer women using hormone replacement therapy (HRT), some experts suggest breast cancer rates are not dropping at all. Just as many women may have breast cancer, they say. They just aren't being screened for it.

"
We have been aware for several years that the number of radiologists who specialize in mammography have been decreasing, and that there are places in the United States where women have difficulty getting access to mammography," Dr. Len Lichtenfeld, deputy chief medical officer for the American Cancer Society, wrote on the society's blog just after the public announcement.

"
If mammography use has reached a peak and is now decreasing, we may actually be diagnosing fewer cancers when they can be most effectively treated, Lichtenfeld said. "If you don't get a mammogram, you don't diagnose a cancer."

The research linking the decline in HRT to the drop in breast cancer came from the M.D. Anderson Cancer Center in Houston and was discussed at a breast cancer conference in San Antonio on Thursday. The research, based on a report by the National Cancer Institute, showed a seven percent drop in new breast cancer cases between July 2002 and August 2003, corresponding with the results of a 2002 Women's Health Initiative study.

With media reports citing HRT as the direct cause of the drop, some worry the public is getting the wrong message -- specifically women still taking hormones or those who have taken them in the past. While women not taking hormones are breathing a sigh of relief, others are in a panic.

Dr. Katherine Sherif, director of the Drexel Center for Women's Health at Drexel University College of Medicine in Philadelphia, has spoken already with 15 patients worried about this news.

"What I have told them is that three years is too short of a time to measure the effects of a drug on breast cancer," she said.
"Cancers take decades to develop, and conversely, withdrawing hormones could not result in a decrease in breast cancer in three years -- it's actually absurdly short." There are also concerns women will experience anxiety about other therapies using estrogen, such as in vitro fertilization (IVF).

The study on HRT and breast cancer may be raising more questions than answers -- which could be a good thing. More questions prompt more investigation, more study, more research. And this will hopefully help us figure out one facet of the mystery of breast cancer.

Previous posts on the topic of HRT and breast cancer are as follows.

Laura Bush aims to raise cancer awareness in Middle East

Despite tensions between the United States and the Middle East, Laura Bush announced Monday a plan to raise breast cancer awareness in the Middle East -- first with partnerships with the United Arab Emirates and Saudi Arabia and later with Morocco and Jordan. Joining forces also with the Susan G. Komen Breast Cancer Foundation, the MD Anderson Cancer Center in Houston, and Johns Hopkins Medical Center, the First Lady outlined a plan that will allow governments, hospitals, researchers, and survivors to work globally to defeat breast cancer. Campaigns specific to each country will target research, training, and community-outreach programs. The reason for this partnership -- to raise awareness in countries where women are too embarrassed or too uninformed to seek treatment -- stems from compassion and human decency and a desire to form diplomatic friendships too. Laura Bush, whose own mother is a breast cancer survivor, shared that the tragedy of losing a loved one to breast cancer -- and the joy of watching a loved one survive this same disease -- is felt universally. Breast cancer affects all women in all countries. Borders make no difference in this matter. And helping save lives is the right thing to do.

Does Whitney Houston have a brain tumor?

Despite a threatened lawsuit, The National Enquirer is refusing to back down from its exclusive cover story that Whitney Houston has a brain tumor and states they are standing by the story 100 percent. Meanwhile, multiple-Grammy winning singer Whitney Houston, and her representatives, are denying there is any truth to the rumor and are threatening the tabloid with legal action. Houston has suffered turbulent challenges both professionally and personally over the years, and has been the focus of more than one tabloid story concerning her alleged drug use, career and marriage. It would be sad if she indeed has a brain tumor, but considering the source of the news announcing such a diagnosis, it is difficult to know at this time how much truth there is to the story. Hopefully -- none.

Tiger Woods and Darren Clarke leave golf course

While attending his caddie Steve Williams wedding in New Zealand, Tiger Woods announced he is taking time off to be with his father and will not be playing in any golf tournaments until the U.S. Open in June. "It's kind of up in the air with the situation back home, so I don't know what's going to happen," said Woods. "I'm taking time off. I'm here for this event and for Steve, and to enjoy time off and be with my father, so I won't play for a while." Woods has been very clear in his priorities when it comes to his father, Earl Woods, who is battling prostate cancer. Back in March, Woods remarked, "It puts things in perspective. You hit a bad shot, and you want to get upset with yourself because you know you can hit better shots, but in the whole scheme of things, it's just a golf shot."

It is also reported that Darren Clarke withdrew from the Shell Houston Open after his first round to return home to be with Heather, his wife, who has been battling breast cancer for the last four years. Sadly, the cancer has spread to her bones and liver. They have two sons. He did not make any public comment. The PGA issued a statement on his behalf, letting everyone know he had left the tournament. In 2005, Clarke took much of the season off to be with his wife as she underwent chemotherapy.

According to the American Cancer Society, three out of four families will be touched by cancer -- but each time you hear news that another family is facing the tough circumstances of cancer never lessens the heartbreak felt for each one of them.

August 13, 2006 Update: Darren Clarke has lost wife after long struggle with breast cancer.
May 03. 2006 Update: Tiger Woods loses father to cancer.

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