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Posts with tag hpv

Self-collection of HPV testing specimens feasible according to study

In a new study published in CMAJ, Dr. Gina Oglivie and colleagues explored the feasibility of women self-collecting specimens for HPV testing. They focused on women who might not make full use of screening programs such as women who were homeless or involved in the sex trade.

Nurses recruited women from women's shelters and alleys in Vancouver's Downtown Eastside. Of the 151 participants, almost 29% tested positive for high-risk HPV. The nurses were able to recontact over 80% of the patients who tested positive to refer them for further testing.

The authors conclude that self-collection of specimens is feasible for women who are at high risk of HPV infection.

Cancer: The kissing disease?

It used to be that Mononucleosis was known as the Kissing Disease. We were warned not to play spin the bottle because we could end up missing school from mono, though that was a desirable prospect to some students and we were sure to make a full recovery in a few months. But these days, kissing can lead to so much more than just mono -- this article suggests that HPV can be transmitted simply by kissing, although it's more likely to be spread through oral sex, and this can lead to cancer. Another cause of the rising numbers of cancer? It's thought that smoking cannabis is to blame for some oral cancers, although this is unsubstantiated.

What do you think -- is HPV really a 'kissing' disease?

Variety of Pap virus is consistent across continents, vaccines should be effective around the world

The distribution of the different types of human papilloma virus that cause cervical cancer are consistent across the world, according to a new study from the University of North Carolina at Chapel Hill.

This means that the vaccines that are currently available to protect against the two most prevalent types of HPV could prevent about 70 percent of invasive cervical cancer cases not just in the U.S, but around the world.

The researchers report that HPV16 is the most common and HPV18 is the second-most common typie in all continents. Gardasil by Merck protects against both of these types as does a similar vaccine developed by GlaxoSmithKline.

Lead study author Jennifer Smith, Ph.D cautions, "While having these vaccines represents a significant step forward, HPV-vaccinated women will need to receive clear messages that they still need to obtain their recommended Pap smears for cervical cancer prevention, given that HPV vaccines will not prevent all invasive cancer or high-grade lesions."


Cervical cancer: a disease of 'loose' women?

It's been proven that cervical cancer has a significant connection with unprotected sex and STDs, particularly HPV. So is issuing a drug proven to prevent HPV to school-age girls a way to help them protect themselves from cancer? Or is it, as the Christian Voice in Britain believes, the equivalent to calling all school-age girls promiscuous, in turn suggesting that they are not morally intelligent enough to abstain from sex until marriage?

This debate has arisen in the UK in response to a call from a group called Jo's Trust to vaccinate school-age girls against HPV with a drug called Gardasil, which has been shown to protect against HPV 100%. Stephen Green of the Christian Voice has this to say about it:

The message is one of despair, disrespect and low expectations. Anyone giving this drug to a girl is telling her: "I think you are a slag". But it is also irresponsible and will raise promiscuity, teenage pregnancy and, worst of all, infertility. Young women will be thinking they have more protection than they actually have.

What are your thoughts on this? Is a nation-wide vaccination a good idea?

Cervical cancer vaccine Gardasil reducing the risk of other cancers

Gardasil, a vaccine against four types of the human papillomarivus (HPV), may reduce the risk of cancers of the vagina and vulva in addition to reducing the risk of cervical cancer.

The HPV virus can lead to precancerous or cancerous changes to the cervix, vagina, penis and anus. Researchers combined information from three clinical trials to evaluate the effectiveness of Gardasil on the risk of precancerous changes to the vulva and vagina.

The study found that among women who had not been infected with the HPV virus, Gardasil was 100 percent effective against precancerous changes to the vulva or vagina. Among those that had been infected with a certain strain of the HPV virus, Gardasil was 71 percent effective. Gardasil was 49 percent effective against all precancerous changes to the vulva or vagina.

The researchers concluded "With time, such vaccination could result in reduced rates of HPV-related vulval and vaginal cancers".

Thought for the Day: When Pap tests are not the best

There is a new test that can identify potentially serious problems much earlier than the standard Pap smear, according to a recent large Danish study.

Think about this:

A new HPV test effectively checks women 40 and older for the virus that causes cervical cancer. The women who carry the virus are at significant risk for the disease and can truly benefit from this test. Women younger than 40 can still contract the virus but it tends to come and go and isn't as likely to lead to cancer. These under-40 women are sill better off receiving the standard Pap test, say researchers.

Source: Good Housekeeping, May 2007

Oral sex linked to throat cancer

My friends over at That's Fit recently posted this item about one of the leading causes of throat cancer -- Oral sex. The threat is so serious, in fact, that it beats the risk associated with smoking or drinking alcohol by nine times. Surprised? I am.

But the connection between throat cancer and oral sex is also linked to HPV (Human papillomavirus), a sexually transmitted disease that increases the chance of contracting cervical cancer in Women. What's even more scary is that it's estimated that 80% of Women contract HPV at some point during their life. And as Jonathon points out, the strong connection between HPV and cancer of the genitals should lead us to anticipate that the virus can cause cancer in other parts of our bodies too.

Still, the statistics -- especially that oral sex is nine-time more likely to give you throat cancer than smoking -- are pretty alarming. Don't you think?

Gay, bisexual men lobby for HPV vaccine

It's not yet clear if the drug Gardasil, the vaccine intended to prevent the human papillomavirus (HPV) in females, is effective for men. But some men are signing up for the chance to take the drug.

Gay and bisexual men in San Francisco are asking their doctors for the vaccine with hopes it will prevent anal and penile cancer, also caused by HPV.

"The prevalence of anal cancer among gay and bisexual men is very high," says Jason Riggs, spokesman for the STOP AIDS Project. "So that's why some people are looking at this as a possible preventive cure for anal cancer and HPV that causes anal cancer."

Anal cancer occurs among gay and bisexual men at a rate 35 times higher than that of the general population. And it occurs more in those infected with HIV.

Newly released recommendations for HPV vaccine

The Human Papillomaviruses (HPV) vaccine called Gardasil can protect from the infection of four types of the HPV virus. Two of these types cause up to 70 percent of all cases of cervical cancer.

Recommendations were released by the Advisory Committee on Immunization Practices (ACIP) regarding the use of Gardasil. The FDA approved Gardasil in June 2006.

The role of ACIP is to advise the Director of the Centers for Disease Control and Prevention (CDC) and the Secretary of the Department of Health and Human Services (HHS) about vaccine usage and vaccine-preventable diseases.

The recommendations published by the ACIP:

  • Recommended age for routine vaccination of girls is 11-12 years.
  • The vaccine can be given to girls as young as 9 years.
  • Catch-up vaccination is recommended for girls and women between the ages of 13 and 26 years who were not vaccinated previously or who did not complete the full vaccine series (the vaccine is administered in three separate doses).
  • Routine cervical cancer screening remains important following vaccination.

The ACIP's recommendations can influence policy and practice, but are not directly linked with school and daycare entry laws. These laws are made by individual states.

I Hate Tumors: JANE magazine essay captures readers

Tears are streaming down my face. I can't stop them, and I'm not sure I want to. In a way, I want to feel the tragedy of life lost to cancer because it makes it all real. It makes it personal. It makes me realize the same tragedy could happen to me, my family members, my friends. It makes me want to make a difference even more now that I've seen the chilling pictures of a young woman dying of cervical cancer than moments earlier when I was moved mostly by my own breast cancer journey.

I first read about Heather Lyn Martin on the JANE magazine website, home of a beautifully-written story -- I Hate Tumors -- by Sara Lyle, long-time friend of Heather and senior editor for JANE, a publication for 20-something women. Sara's words powerfully depict the life and death of her friend, stricken with a disease she was sure she would beat. So sure, in fact, she asked Sara to help tell her success story.

Sadly, Heather never got to tell much. Because she died much too soon, at the age of 28. So Sara told the story through her own words and photos -- the same ones responsible for my tears -- and has just recently written a second essay, one year after her first story started reaching young people everywhere.

Sara wrote Why I Still Hate Tumors after inspiring many young women to open their eyes to the realities of a deadly disease. Her words serve to raise awareness about the dangers of cervical cancer -- and the HPV virus that causes it -- and to point women in the direction of resources critical for preventing and conquering the disease.

Sara, because of the death of her dear friend, is saving lives with her message. And she just may save yours.

To see all that Sara has to offer in the fight against cervical cancer and other hated tumors, visit her I Hate Tumors website.

Viruses and cancer

Discoveries have linked certain viruses to cancer growth. The hepatitis B virus is related to liver cancer. Women who develop cervical cancer have had a human papilloma virus (HPV) infection but not all women with HPV infection will develop cervical cancer. Stomach ulcers are likely caused by Helicobactor pylori, or H. pylori a bacteria and the ulcers can grow into cancer. Viruses attack cells in the body and once these cells are corrupted they begin to grow uncontrollably, eventually leading to cancer.

With these discoveries leads us to the knowledge that protecting the immune system in the body and keeping viruses at bay, is important in preventing cancer. Viruses enter the body through everyday activities like eating, breathing and sexual activity. Eating well, exercising and avoiding alcohol and cigarettes are good ways to keep your body's natural defenses functioning at their best. Staying protected with condoms during sexual intercourse helps protect you from sexually transmitted viruses and diseases. Learning healthy life style habits is the beginning of keeping cancer at bay. Focusing on nutrition, exercise, body weight, keeping toxins out of our bodies and our home environment ,and lowering stress will all help boost the immune system.

Merck stops cervical cancer vaccine campaign

Merck, maker of the cervical cancer vaccine Gardasil, is backing off its lobbying campaign following pressure from medical groups and parents who believe the vaccine should not be mandated as a school attendance requirement for adolescent girls.

The public outcry that caused Merck to announce its stop order on Tuesday stems from the fact that the vaccine protects against the sexually transmitted human papilloma virus (HPV), which causes cervical cancer. School-mandated vaccines are typically for diseases spread through casual contact, such as measles and mumps.

Merck's medical director for vaccines, Dr. Richard M. Haupt says, "We're concerned that our role in supporting school requirements is a distraction from that goal, and as such have suspended our lobbying efforts," adding that the company will continue providing information about the vaccine upon request.

Gardasil, launched in June and the first vaccine to prevent cervical cancer, has inspired controversy since day one. There's the cost -- $360 for three required shots -- and all sorts of insurance concerns and conservative groups who worry the vaccine encourages premarital sex and interferes with parental rights. Even those in support of the vaccine -- like the American Academy of Pediatrics and the American Academy of Family Practitioners -- question Merck's quick push to market this drug, especially in light of the company's withdrawn painkiller Vioxx.

"I believe that their timing was a little bit premature so soon after (Gardasil's) release, before we have a picture of whether there are going to be any untoward side effects," says Dr. Anne Francis, who chairs an American Academy of Pediatrics committee.

Legislatures in 20 states have taken steps to mandate the vaccine for young girls. And with the exception of Texas governor Rick Perry's February 2 executive order requiring Texas girls entering the sixth grade in 2008 get vaccinated, nothing has been made official so far.

Texas first to mandate cervical cancer vaccine

Come September 2008, 11 and 12-year-old girls in Texas entering the sixth grade will receive three shots of the Gardasil vaccine used to prevent cervical cancer.

Texas is the first state to require that young schoolgirls receive the cervical cancer vaccine, approved for use by the FDA in June and proven to protect against the most common strains of the human papilloma virus (HPV) -- the cause of most cervical cases cervical cancers.

Texas governor Rick Perry (R), who just signed an executive order making this mandate official, believes the high cost of treating diseases and ensuring the health and well-being of our population justifies the vaccine requirement.

Perry, who has been met with opposition from those concerned that HPV vaccination of young girls promotes premarital sex and interferes with parental rights, will allow parents to opt out of the vaccination requirement with documentation citing religious or philosophical reasons. But he hopes most will comply with the cervical cancer vaccine he believes is no different than immunization against diseases such as polio.

Gardasil drugmaker Merck stands to make billions if the vaccine is made mandatory across the country. The series of three necessary shots cost $360.

Perry, who received $6,000 from Merck's political action committee during his re-election campaign, has other ties to the company. His former chief of staff is one of Merck's three lobbyists in Texas, and his current chief of staff's mother-in-law is state director for Women in Government -- a group active in introducing bills across the country that affect women.

First Middle East country acquires cervical cancer vaccine

The United Arab Emirates (UAE) is the first country in the Middle East to acquire the cervical cancer vaccine, Gardasil.

Comparisons of cervical cancer statistics for the years 1998 through 2005 show incidences of the disease tripling during this span of time. So acquisition of the vaccine is a true blessing for the women of this country.

"We are proud to have placed the UAE on the map with leading countries such as the US, Australia and EU by approving Gardasil, the first breakthrough vaccine that prevents the cancer," said Dr Wisam Haddadin, Franchise Manager, Gulf Region, Merck Sharp & Dohme.

Gardasil, distributed by Merck, Sharp, & Dohme, is now available in more than 33 countries for the prevention of cervical cancer, most commonly caused by HPV (human papilloma virus). About 2.3 million women are currently diagnosed with cervical cancer worldwide. About 800 women die of the disease every day.

Dr. Len's cancer year in review

Dr. Len Lichtenfeld, MD, is the deputy chief medical officer for the American Cancer Society. He is also a blogger and authors his very own blog -- called Dr. Len's Cancer Blog.

Dr. Len writes on his blog about all sorts of topics related to cancer. He shares his opinion on the recent drop in breast cancer cases (December 15, 2006), he promotes the Great American Smokeout (November 14, 2006), he sounds off on lung cancer screenings (October 25, 2006), and he urges parents to always slather sunscreen on their children (October 5, 2006). He has so much more to say -- and his blog is a great stop for those wishing for more information on hot cancer topics.

As this year comes to a close, Dr. Len offers a review of what he believes were the hottest cancer topics of 2006.

Dr. Len reflects in his blog about decreased cancer death rates that represent real progress in the fight against cancer. He calls the HPV vaccine a breakthrough and he recaps the STAR trial -- a comparison of raloxifene to tamoxifen to reduce the risk of recurrent breast cancer in post-menopausal women -- with emphasis on how raloxifene proved just as effective as tamoxifen, but with a better safety profile. He calls new targeted therapies a dream -- with a hefty price tag -- sure to garner debate and discussion in 2007.

Dr. Len reviews the Surgeon General's report on second-hand smoke -- it's harmful to non-smokers, the report says -- and he marvels at the capability of science to approach an understanding of what makes a cancer cell a cancer cell. He also remarks on how remarkable it is that chronic myelogenous leukemia is in fact chronic and no longer fatal, thanks to the drug Gleevec.

Of course, there is ample attention given to the declining incidence of breast cancer, reportedly due to less women using hormone replacement therapy, and the risks weighing on those who are overweight and obese, and survivors and supporters who gathered for Celebration on the Hill -- the site of one incredible American Cancer Society event.

Dr. Len closes his review of 2006 with recognition of three celebrities who lost their lives this year to cancer --
Dana Reeve, Ann Richards, and Ed Bradley. And while he recognizes there are other lives and other stories that deserve mention, there is simply not enough time or space for him to do justice to every noteworthy item.

"What we have seen over the past year is an incredible leap forward in cancer research, diagnosis and treatment, and I suspect there are going to be even more exciting developments in the coming year," says Dr. Len who looks forward to 2007 -- a year that is sure to deliver more hope and more progress in the fight against cancer.

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