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Erbitux fails in pancreatic cancer trials

ImClone Systems Inc.'s drug Erbitux has failed to help pancreatic cancer patients live longer. It's also failed to grow ImClone's market -- not surprising since it's the company's only drug.

Imclone, partnering with Bristol-Myers Squibb Co., wanted to see Erbitux -- already cleared for use with colon, head, and neck cancers -- extend the lives of patients with cancer marked by a spread to the pancreas.

No one is giving up just yet, and Imclone plans additional tests on Erbitux's use in pancreatic cancer. A study using a combination of Erbitux and Avastin and chemotherapy is up next.

"There are reasons to think Erbitux works in pancreatic cancer, but the current results are not as dramatic as we hoped," said Alex Denner, lead for an executive committee that manages ImClone. "We remain committed to evaluating Erbitux in pancreatic cancer."

If approved, Erbitux will compete with Tarceva, sold by Roche Holding AG, Genentech Inc., and OSI Pharmaceuticals Inc. as a treatment for pancreatic and lung cancers.

About 37,170 new cases of pancreatic cancer are expected to occur in 2007 in the United States. And 33,370 people will die from the disease, according to the American Cancer Society. Pancreatic cancer is one of the most aggressive cancers, and there is no screening option that works at catching the disease in its early stages.

Only about 5 percent of patients with pancreatic cancer are still alive five years after being diagnosed.

Baby teeth rich in stem cells, may one day save lives

Parents may want to save their kids' baby teeth for more than just nostalgic reasons -- they may want to save them because they are rich in stem cells and the pulp tissue could provide the means to treatment for injuries and disease. BioEden Inc. is a new company out of Austin, Texas pioneering this effort that is so new some doubt science will ever catch up with the expectations of this firm. But President Jeff Johnson says all evidence indicates that baby teeth are a wonderful source of stem cells -- cells that doctors and researchers pursue for their capability of replicating and morphing into specialized cells that can be used to repair the body. Experts think baby teeth stem cells might one day be used for bone, teeth, and even nerve cell regeneration which could hold potential for spinal cord injuries and Alzheimer's and Parkinson's diseases.

Parents may find brochures in their dentist offices featuring the benefits of banking their children's teeth once they fall out. And pursuing tooth banking is no different than pursuing any other dental procedure. There are fees involved, of course -- banking fees and perhaps referral fees from dental offices -- and other considerations that each parent must weigh. Dr. Phil Hunke, president of the American Academy of Pediatric Dentistry and pediatric dentist for 32 years, says the idea of removing cells and freezing them holds true promise -- and he may want to bank the tooth of a child or grandchild once he learns more. Dr. Kevin Donly, a professor of pediatric dentistry, says he sees some potential but will not be banking teeth for his three little boys. He just doesn't think he's at the point where it's necessary. Another pediatric dentist -- Dr. John Updyke -- believes that if money were not an issue, all parents should bank their kids' teeth. But many young families can't afford the initial $595 and the $89 annual storage cost it requires. And without a solid scientific backing, tooth banking might not come up as a priority for many when it may take 10 years or more to even determine how useful these specific stem cells will be.

Time to bring the best of Weblogs, Inc, live and direct to you

The Weblogs, Inc. network features over 100 independent, unfiltered bloggers producing over 1,000 blog posts a week across over 75 industry-leading blogs. Each week we ask our bloggers to choose their top posts, which we bring to you in one easy-to-read weekly post. You’ll find links to the hottest posts from the past week after the jump including a Macromedia MAX ticket for next to nothing, the Charles Bronson farm and the Nintendo Revolution controller. Plus, when your done with the full listing after the jump check out the Open Source Weblog for a special live blogging event today (September 17) only.

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The very best of Weblogs, Inc for your viewing pleasure

The Weblogs, Inc. network features over 100 independent, unfiltered bloggers producing over 1,000 blog posts a week across over 75 industry-leading blogs. Each week we ask our bloggers to choose their top posts, which we bring to you in one easy-to-read weekly post. You’ll find links to the hottest posts from the past week after the jump including a special review contest, celebrity virginity, and even the best Windows emulator for Mac. Enjoy!

Continue reading The very best of Weblogs, Inc for your viewing pleasure

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