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Posts with tag infections
Posted Jun 28th 2007 4:00PM by Vicki Blankenship
Filed under: Bladder Cancer, All Cancers, Research

The National Cancer Institute shows studies have found the following risk factors for bladder cancer.
1. Age - The chance of bladder cancer goes up as you get older and is rarely found in anyone under 40 years old.
2. Tobacco - Cigarette smokers are three times more likely than non smokers to develop bladder cancer.
3. Occupations - People who work in these professions or who handle these products have a higher risk of developing bladder cancer. Rubber, chemical, leather, textile, printers, painters, machinists, metal workers, hairdressers, and truck drivers.
4. Infections - Certain parasites increase the risk of bladder cancer.
5. Race - Whites get bladder cancer twice as often as African Americans and Hispanics. The lowest risks are Asians.
6. Gender - Men are three time more likely to develop bladder cancer which may be because of the above occupational risks.
7. Chlorine - By products of chlorine are being closely studied.
8. Saccharin - The artificial sweetener has shown to cause cancer in animals and is being studied closer for the risks on humans.
If you have blood in your urine, pain during urination, or frequent urination or the feel the need to urinate often, please discuss your concern with a doctor. Early detection of bladder cancer has been a proven factor in the survival rate of this disease.
Posted Jun 20th 2007 3:55PM by Vicki Blankenship
Filed under: Blood Cancer, Bone Cancer

The American Cancer Society estimates that approximately 16,600 new cases of myeloma are diagnosed each year in the United States. Bone pain is the most common early symptom of myeloma. Most patients feel pain in their back or ribs, but it can occur in any bone. The pain is usually made worse by movement.
Patients fatigue more easily and often feel weak. They may also have a pale complexion from anemia which is a common medical problem for patients with myeloma and may contribute to the fatigue. If the disease progresses, the concentration of normal cells in the blood may also decrease. Headaches, bruising, nose bleeding, gastrointestinal bleeding, and tingling or numbness in extremities are all symptoms of myeloma.
Patients may have repeated infections because antibodies to invading viruses, bacteria or other disease agents are not made efficiently of in adequate amounts. Urinary tract, bronchial, lung, skin, or other sites of infection may be the first sign of the disease. In addition, recurrent infections may complicate the course of the disease.
Posted Mar 12th 2007 10:25AM by Vicki Blankenship
Filed under: Drug, All Cancers, Research, Daily news

Devastating blood born fungal infections that can be lethal for cancer, HIV/AIDS, and organ transplant patients may be treated more successfully, thanks to a new drug delivery method of Amphotericin B developed by researchers at the University of British Columbia in Vancouver. Because the oral form of the drug is easier to administer and cheaper than intravenous delivery more patients would have access to the medicine. Amphotericin B deoxycholate (AmBd) has been the gold standard for the treatment of systemic mycoses for the past 5 decades. The intravenous form of the drug caused severe kidney toxicity as well as serious tissue damage at the intravenous injection site. This research was triggered by clinicians needing a way to kill these fungal infections without risking the patient's kidney. The new form can be can be taken by mouth with minimal side effects boosting effectiveness and dramatically reducing toxicity.
It was effective in treating candida albicans an infection prevalent in HIV/AIDS and cancer patients receiving chemotherapy,and can cause symptoms ranging from cough to brain damage. Research funding for this project was provided by the Canadian Institutes of Health Research, Canada's major agency responsible for funding health research. Composed of 13 Institutes, CIHR provides leadership and support to more than 10,000 health researchers and trainees across Canada.
Posted Jan 26th 2007 5:25PM by Kristina Collins
Filed under: Leukemia, Drug, Blood Cancer, Research, Cancer Survivors
Noxafil (posaconazole), an anti- fungal agent may be better than other anti-fungals in helping cancer patients that have GVHD.
GVHD, graft-versus host disease, is a potential complication that can happen after a stem cell transplant. What is really happening is that the new stem cells given from a donor are now giving the patient a chance to build a new immune system--hopefully one that will give a cure. The foreign immune system can begin to attack the cancer patients body that received the transplant. Just like your immune system might reject a heart transplant, the new immune system is seeing the organs of the body as foreign and attack.
To combat this from happening the patients are usually given agents that suppress the immune system. This however, can then cause infections that can quickly develop into a life threatening situation. Researchers are continuing to look for ways to combat the infections that arise.
Noxafil was compared to Diflucan in a study of 600 patients with GVHD who were also receiving therapy to suppress their immune system. The anti-fungal agent that won out was Noxafil for the prevention of fungal infections.
Posted Jan 18th 2007 11:00AM by Jacki Donaldson
Filed under: Pancreatic Cancer, Research, Daily news

As if gum disease is not a painful enough experience, a Harvard study shows the disease can more than double the risk of pancreatic cancer. Additionally, those with a history of gum disease and recent tooth loss have a 2.7-fold increase in risk.
Previous studies have linked gum disease and pancreatic cancer, but smoking -- which contributes to both diseases -- has never been taken into consideration.
Researchers in this study, who controlled for smoking, followed 51,529 men for 16 years and found those who reported gum disease were 64 percent more likely to have pancreatic cancer. Nonsmokers with gum disease were twice as likely to develop the disease.
It was also determined in the study, published in the January 17 issue of the
Journal of the National Cancer Institute, that the more severe the gum disease, the higher the cancer risk.
While it is not clear why gum disease is linked to cancer risk, researchers believe perhaps long-term gum infections trigger body-wide inflammation -- and inflamed tissues send chemical signals that promote tumor growth.
Posted Jan 9th 2007 10:00AM by Jacki Donaldson
Filed under: All Cancers, Cancer Survivors

I was driving down the highway today when I looked to my right and saw out of the corner of my eye a blue pick-up truck. The driver -- a man -- wore a cowboy hat and his passenger -- a woman -- wore a turban and a mask that covered her nose and mouth. It was similar to the yellow paper-like mask I wore during chemotherapy when low blood counts and fevers knocked my body all out of whack. So when I briefly glanced at this woman, I diagnosed her -- with cancer.
I guess my medical radar could be off, my diagnosis could be wrong -- but I suspect not. It was an all-too-familiar sight -- the bald head obviously disguised, the mask warding off germs and infection, the eyes the only visible marking of a face. Yet it was still a startling sight, a sad sight, a sight that never loses its power over me as I travel the highway of life.
I am thankful to still be on the highway -- to not have been tragically run off the road -- and the woman whose path I crossed today may be just fine after her journey with cancer runs its course. But it's such a dismal sight -- the ravages of cancer visibly displayed on the undeserving victims of a harsh disease.
Maybe my approach is all wrong. Perhaps it would be better if my vision today prompted thoughts of a spirited warrior bravely battling a fierce opponent with victory the likely outcome. But instead I saw sickness and sadness. Because this is how I felt -- sick and sad -- when my appearance was marked by a hat and a mask.
But now I am healthy and happy. And I am confident I will one day see my co-survivors in a more hopeful light. There is hope, after all, for each of us diagnosed with this life-threatening disease.
Perhaps after I've been on the road to recovery for a while longer, dismal will turn to dazzle. Perhaps then I will see as much shine in those wearing cancer on their sleeves as I saw today in the blue paint of the truck that passed me on the highway.
Posted Dec 26th 2006 9:00AM by Jacki Donaldson
Filed under: Research, Daily news

Kidney transplants can save lives. They can also increase the risk of developing a variety of cancers, according to Australian researchers who report a risk 300 percent higher than in the general population.
Most cancers developed in kidney transplant patients have a known or suspected viral origin, suggesting the weakened immune systems in these patients limit protection against cancer.
"The immunosuppressive drugs transplant patients take lower their ability to fight off infections that can trigger malignancy", the lead researcher said. "We believe the increased incidence of infection leads to the infection that results in cancer." She also notes there is probably an even greater risk of cancer among heart and lung transplant patients because these patients receive more powerful immunosuppressive drugs.
Researchers gathered their findings by comparing the incidence of cancer in 29,000 patients with end-stage kidney disease who received kidney transplants. Data was collected beginning five years prior to transplantation, during dialysis, and after transplantation. Researchers then consulted an Australian registry to identify cancers occurring between the years of 1982-2003. They compared the statistics with the number of cancers seen among transplant patients.
These cancers included melanoma, Kaposi's sarcoma, non-Hodgkin's lymphoma, Hodgkin's disease, leukemia and cancers of the lip, tongue, mouth, salivary gland, esophagus, stomach, colon, anus, liver, gallbladder, lung, connective and other soft tissue, vulva, cervix, penis, eye and thyroid. There was also an increase in nasal cavity and vaginal cancers.
This study has important implications for future immosuppression. Patients should give considerable thought to quality-of-life transplants -- such as face transplants and hand transplants -- and should carefully weigh the risks of weakened immunity. On a brighter note, this study might help prompt research on medication that can selectively target the part of the body responsible for rejecting a transplant. Because right now, medications affect the entire immune system -- and this is what makes patients more prone to developing cancer.
Posted Dec 11th 2006 11:00AM by Kristina Collins
Filed under: Childhood Cancers, Leukemia, Non-Hodgkins Lymphoma, Hodgkin's Lymphoma, Blood Cancer, Stem Cell, Research
Children that undergo bone marrow transplants can develop life threatening infections while the immune system is trying to regenerating itself. St. Jude Children's Research Hospital thinks they have found a better way to harvest stem cells that are more vigorous in reproducing and rebuilding the immune system. These stem cells would reduce the time it takes for the immune system to rebuild--reducing the risk of infection.
When harvesting the donated bone marrow a specific antibody is used to find the vigorous stem cells that mature and reproduce faster. They found that using a new antibody along with the one already used might prove to have better results in capturing the best stem cells needed. This could help the donated bone marrow to take hold faster and lessen the risk of the time children are exposed to serious infections.
Although the studies so far have been done on mice, the researchers believe that this is promising information that with further studies can translate into better treatment for children that need to undergo a bone marrow transplant.
Posted Oct 25th 2006 10:00AM by Jacki Donaldson
Filed under: Childhood Cancers, Research, Daily news, Cancer Survivors

The overall cure rate for the 20,000 children diagnosed with cancer in the United States each year is more than 75 percent. Sounds good -- especially when 50 years ago, most children diagnosed with cancer died. But considering that only one in three childhood cancer survivors remain healthy, perhaps this is not such good news.
Thirty years after diagnosis, about 40 percent of survivors have a serious health problem and one-third have multiple problems. Strokes, heart disease, and kidney failure are just a few of the major health concerns that plague many survivors who have entered adulthood.
Doctors have long known that cancer treatments can cause new cancers later in life. But the Childhood Cancer Survivor Study -- the largest ever childhood study of its kind -- shows there are other long-term health problems. Researchers studied 10,000 survivors -- past studies examined 200-300 survivors -- and found these survivors were eight times as likely as their siblings to develop severe and life-threatening conditions. They found survivors of bone tumors, nerve and brain cancer, and Hodgkin's disease faced the highest risk.
The source of these later-in-life health problems vary. Kidney failure may result from damage caused by chemotherapy or radiation or the infections children suffer when their immune systems are weakened. Drugs used to treat infections may also be to blame. Strokes may result from head and chest radiation.
Cancer treatment for people of all ages comes with a price. We buy time, we buy life in exchange for the unknown. But for children -- who stand to live longer than adults -- there is a greater unknown. Sadly, there is a dark side to surviving cancer.
Posted Jul 28th 2006 10:00PM by Dalene Entenmann

Although researchers have considered the possibility that the bark of the White Birch tree might contain a compound, known as betulinol, with the ability to fight prostate cancer, until recently there was no way to test it because they did not know how to make the compound water-soluble.
Now that
Weill Medical College of Cornell University researchers have solved that problem, laboratory tests on mice are showing it is indeed effective in killing prostate cancer cells.
"Years of research appear to have paid off, and now animal tests on this potential anti-cancer agent can finally proceed. Already, in mouse studies, we've found that our water-soluble compound - called Boc-lysinated-betulonic acid -- has achieved up to 92 percent inhibition of prostate tumor growth compared to controls," states lead researcher Dr. Brij Saxena.
While the study into the cancer-fighting properties of the White Birch tree might be new, the White Birch tree has a history of medicinal uses. According to the
Living Memorials Project website White Birch tree information page, Native American Indians used the leaves and bark of the tree as a tea to treat fevers, stomach upset, and rheumatism. The bark was boiled to make poultices for minor wounds, and an oil made from the bark to treat bladder infections, rheumatism, gout and nerve pain. In Europe, the leaves were used to treat skin rashes, hair loss, rheumatic complaints, and to purify the blood. Birch tar oil was used to treat chronic skin diseases.
The Phytochemical and Ethnobotanical Databases of United States Department of Agriculture includes information on betulin and betulinic acid as showing that it inhibits cancer, and the compound is also known to be anticarcinomic; anti-flu; anti-inflammatory; antiviral; and a prostaglandin-synthesis-inhibitor.
Posted Jul 19th 2006 12:00PM by Dalene Entenmann
Filed under: Childhood Cancers, Prevention, Research, Environment

In the 11th report of the Committee on Medical Aspects of Radiation in the Environment (COMARE), children growing up in an affluent urban environment and children from rural areas are at higher risk for developing many cancers.
Researchers studied cancer clusters where leukemia and other childhood cancers were reported, and have come to the conclusion that affluent children are being raised in an environment that is too clean. Called the
dirty hypothesis, children living in too sterile an environment where they are not exposed to infection have weak immune systems.
For rural children, infection brought in to the rural community by people from larger populated urban areas, might be causing genetic damage that leads to cancer.
With the exception of the processing plant at Sellafield in Cumbria, and Dounreay in Scotland, the researchers also state they found no general pattern of increased cancer incidence around nuclear plants.
The researchers feel confident in the reported results of this study. They invite further study into the hypothesis of their findings. The database was constructed from the National Registry of Childhood Tumours by staff of the Childhood Cancer Research Group in Oxford, and included 12,415 cases of childhood leukemia and non-Hodgkin lymphoma and 19,908 cases of children with solid tumors registered under the age of 15 in England, Wales and Scotland from 1969 to 1993. To download the 160 page report, go
here.