New research may one one day help in the diagnosis and prognosis of the nation's number four cancer killer of men and number five cancer killer of women. The killer: pancreatic cancer.

Findings from an Ohio State University study show pancreatic cancer cells may leave signs in gene-related molecules called microRNAs.

Published in The Journal of the American Medical Association, this study examined pancreatic tissue from 65 people with the disease and 42 people with chronic inflammation of the pancreas, called chronic pancreatitis.

I've always heard the use of herbs and supplements and alternative therapies can be a potentially dangerous pursuit when combined with cancer treatment. But this may not be entirely true.

Think about this:

Using Chinese herbs alone or in conjunction with chemotherapy may help protect a breast cancer patient's bone marrow and immune system. It may also improve the overall quality of life for women, say researchers at the Chinese Cochrane Centre in Chengdu, China.

It is well known that women receiving chemotherapy for breast cancer experience significant short term side effects such as nausea, vomiting, fatigue, inflammation of the gut lining, decreased numbers of red and white blood cells, and decreased numbers of blood platelets. Those is search of some relief may wish to give Chinese medicinal herbs a try.

Researchers say there is conventional evidence indicating that these medicines are safe and effective. Still, "further trials are needed before the effects of traditional Chinese medicines for people with breast cancer can be evaluated with any real confidence," says one professor involved in this area of study.

I never thought I'd hear this one -- that women whose tonsils were removed during childhood may be at increased risk of developing pre-menopausal breast cancer. But sure enough, that's what researchers at the University of Buffalo are reporting.

Think about this:

Researchers say the association between tonsillectomies and breast cancer may be related to the loss of protective function when tonsils are removed. Also, tonsils can be markers for infection in childhood. Some infections cause inflammation which can contribute to cancer. When the tonsils are gone, markers are gone.

Other studies have linked tonsillectomies with an increased risk of Hodgkin's lymphoma, leukemia, and breast and prostate cancers. This study, reported at the 100th annual meeting of the American Association of Cancer Research, confirms the breast cancer connection -- but further study is still necessary.

Katherine Schaefer was investigating methods for treating the inflammation seen in Crohn's disease and ulcerative colitis when something terrible happened -- she noticed her carefully cultured cells were dead. And then something wonderful happened -- she realized she had stumbled upon a potential new method of attacking cancerous tumors that have become resistant to existing drugs.

Schaefer and her colleagues at the University of Rochester Medical Center in New York were testing a compound called a PPAR-gamma modulator -- a compound never considered a cancer drug, or a drug of any kind really -- when Schaefer made a calculation error and used a lot more of the compound than she should have. And her cells died.

Upon further study, Schaefer found the compound killed just about every possible epithelial tumor cell. These cells line organs such as the colon and also the skin. The compound, that works like taxane drugs but without eventual tumor resistance, also killed colon tumors in mice without making them sick.

The research team, whose findings are published in the journal International Cancer Research, plans more safety tests in mice. And eventually, if their outcomes are promising, they plan to design something they can patent as a new drug -- because they would love to see this disastrous lab experiment one day lead to treatment for cancers of the colon, esophagus, liver, and skin.

As if gum disease is not a painful enough experience, a Harvard study shows the disease can more than double the risk of pancreatic cancer. Additionally, those with a history of gum disease and recent tooth loss have a 2.7-fold increase in risk.

Previous studies have linked gum disease and pancreatic cancer, but smoking -- which contributes to both diseases -- has never been taken into consideration.

Researchers in this study, who controlled for smoking, followed 51,529 men for 16 years and found those who reported gum disease were 64 percent more likely to have pancreatic cancer. Nonsmokers with gum disease were twice as likely to develop the disease.

It was also determined in the study, published in the January 17 issue of the Journal of the National Cancer Institute, that the more severe the gum disease, the higher the cancer risk.

While it is not clear why gum disease is linked to cancer risk, researchers believe perhaps long-term gum infections trigger body-wide inflammation -- and inflamed tissues send chemical signals that promote tumor growth.

Aspirin, and other nonsteroidal anti-inflammatory drugs (NSAIDs), are known to halt the growth of some cancers, such as colorectal cancer, breast cancer and ovarian cancer, but no one could really explain why. Obviously, as a result it was believed that chronic inflammation might be leading to increased cancer risks. Still, no one could explain how any of this was happening enough to harness the ability to replicate it.

Beth Israel Deaconess Medical Center and Columbia University Medical Center researchers have announced the discovery of a novel tumor suppressor gene that works with NSAIDS to stop the growth of cancer cells.

"Current clinical trials are evaluating a range of NSAIDs for a variety of cancers without any clear vision of the best way to use them," states Towia Libermann, PhD, Director of the BIDMC Genomics Center and Associate Professor of Medicine at Harvard Medical School. "The fact that upregulation of this single gene MDA-7/IL-24 -- correlated not only with cell death induction of numerous types of cancer but also among various diverse classes of NSAIDs, makes this discovery particularly exciting."

As a result of this discovery, researchers believe newer targeted cancer therapies can be developed. To read more about the discovery, visit Beth Israel Deaconess Medical Center and Columbia University Medical Center's Study Explains How NSAIDs Halt Cancer Growth.

Some of the previous posts we have on inflammation, cancer and aspirin are:

• Aspirin: amazing wonder drug in fighting cancer
• Inflammation link between rheumatoid arthritis and cancer
• What aspirin reveals about cancer

An anti-viral molecule, TBK-1, that the body uses to fight viruses, seems to be vital to the survival of cancer cells. Blocking one enzyme, aldose reductase, was found to stop colon cancer cells in cell culture laboratory tests and in mice implanted with human colon cancer cells, according to University of Texas Southwestern Medical Center researchers.

"We got the surprise that this mechanism is involved in cancer cell survival, even though it's normally involved in immune response," stated Dr. Michael White, associate professor of cell biology at the University of Texas Southwestern Medical Center.

"We found something a little bit different -- an Achilles heel of cancer cells that's apparently broadly conserved among many types of solid tumors. This is making us think that there are many other surprises awaiting discovery regarding biological systems that are inappropriately subverted during development of cancer."

The discovery is called dramatic and could lead to new treatments for colon cancer. If blocking a single anti-viral molecule does shut down the biochemical signals that promote inflammation and colon cancer cell growth, as the researchers are reporting from the results of this study, it will be a dramatic discovery.

Simple every day aspirin has long been called a wonder drug, and the wonders of aspirin cease to amaze. The ability of aspirin to effectively fight cancer is a known, according to researchers. In What aspirin reveals about cancer, we posted "Aspirin may reduce the risks from a number of cancers. Why? Medical researchers from different fields of study are coming together on a common thread of evidence suggesting that inflammation in the body may be at the core of many diseases, including cancer."

When we brought you that information, researchers knew the anti-cancer effect of aspirin was tied in to aspirin being an anti-inflammatory but beyond that, the mechanism behind how aspirin worked against cancer was an unknown.

Recently, University of Newcastle scientists have made a new discovery of how aspirin fights cancer. Aspirin appears to cut off the blood supply to a developing cancer tumor. Without a needed blood supply, the tumor has difficulty continuing to grow. High doses of aspirin were used in the study, and high doses of aspirin are not recommended, as the side effects of stomach bleeding can occur. According to the researchers, the normal dose of aspirin did not affect cancer cells, but seemed to disrupt the surrounding proteins that provide a support structure for blood vessels.

While it is not take two aspirin and call me in the morning, the study does show promise in the possibility of new cancer treatments.

This study is published in the October 2006 issue of The Federation of American Societies for Experimental Biology (FASEB) Journal.

Stomach cancer is hard to detect. It has no symptoms in its early stages, and there is no effective screening to detect its presence. So early detection and early treatment for this disease -- that attacks 800,000 people worldwide -- are hard to come by. In Taiwan, stomach cancer is the fifth most common cancer and the focus of study for researchers working to devise a method for detecting stomach cancer in its infancy.

A team of researchers at National Taiwan University Hospital have discovered a toxic factor -- GroES -- that causes stomach cancer. And they have discovered that a simple blood test will show either a positive or negative result for this substance, leading to immediate endoscopic exams for patients who may be at risk for stomach cancer. The test to identify GroES has already achieved a 65 percent accuracy rate.

Apparently, if the human body is infected with GroES, it produces antibodies to the factor and can cause chronic inflammation of the stomach, causing cells to rupture and proliferate. Long-term inflammation can cause stomach cancer. Researchers say about 45 percent of adults in Taiwan are infected with GroES -- and one percent will go on to develop stomach cancer.

Right now, patent applications are underway in the United States, Japan, and Taiwan. Once a kit is developed, a single drop of blood will be all it takes to determine the risk for stomach cancer.

The typical Western diet is lacking in a healthy balance of omega-3 fatty acids to omega-6 fatty acids, and for men with prostate cancer, this can have adverse consequences in controlling tumor growth and PSA levels. In this part of the world, our diet offers too little in the way of omega-3 and too much in the way of omega-6. Researchers found that by balancing the ratio in increasing omega-3 and decreasing omega-6 in the diet, there were able to slow tumor cell growth rates by 22 percent and lower PSA levels a whopping 77 percent.

Omega-3 fatty acids are found in leafy green vegetables, nuts, vegetable oils such as canola and soy, flaxseed, flaxseed oil, olive oil, cold-water fish like salmon, mackerel, sardines and fresh tuna. Omega-6 fatty acids are found in corn, safflower oils, food products made with corn oil (think processed foods and fast foods) and red meats.

According to UCLA researchers, when the fatty acids are not in the right ratio to each other, omega-6 creates an inflammatory response in the body that can promote the growth of tumors, while omega-3 has the opposite effect in acting as an anti-inflammatory.

"This is one of the first studies showing changes in diet can impact the inflammatory response that may play a role in prostate cancer tumor growth," said principal investigator Dr. William Aronson. "We may be able to use EPA and DHA supplements while also reducing omega-6 fatty acids in the diet as a cancer prevention tool or possibly to reduce progression in men with prostate cancer."

These studies were done on animal models, and not humans, but the researchers did use a special mouse model for hormone-sensitive prostate cancer that matched closely prostate cancer in men.

University of South Australia researchers have good news for people trying to lose weight, or maintain a healthy weight, in improving their health and reducing their risks for diseases like cancer. With no other lifestyle changes, taking omega-3 fish oil supplements and engaging in moderate exercise helped people struggling with weight issues -- who are overweight or obese -- effectively burn off extra pounds.

The researchers used tuna oil and sunflower oil in the study, and compared the effects of the two oils with exercise to weight loss results. The participants engaged in exercise that is considered moderate exercise -- walking or running for 45 minutes -- three times a week for three months and were given either tuna fish oil or sunflower oil. The participants who were given tuna fish oil lost weight faster.

The researchers believe that fish oil, which is rich in omega-3, helps the body burn fat, and estimates that most people do not get enough omega-3 in their daily diet. Omega-3 is also found in wild salmon, flaxseed, and certain nuts and seeds.

The Food and Drug Administration (FDA) has issued a health warning to consumers that drinking high-strength hydrogen peroxide products sold online are extremely corrosive and can lead to stomach irritation or ulcers; and injecting the solution intravenously could lead to blood vessel inflammation, bubbles in blood vessels and potentially life-threatening allergic reaction.

In addition, the FDA has issued warnings to two Texas-based firms, DFWX and Frad 35 Inc., who are illegally selling 35 percent hydrogen peroxide products to treat AIDS, cancer, emphysema and other serious diseases.

To understand the strength of the hydrogen peroxide the FDA is referring to, high-strength hydrogen peroxide is 35 percent while the strength of hydrogen peroxide solution sold over-the-counter for disinfecting wounds is only 3 percent.

According to the news release, Donald Worden, owner of Frad 35 Inc., said he would continue selling his 35 percent hydrogen peroxide product and that his website provided links to information about potential medical uses but that he was not promoting his products for that purpose.

The FDA has issued a warning about this product. You have been warned.

On July 20 in Portland, Oregon, Pearl Jam held a benefit concert for the Northwest Chapter of the Crohn's and Colitis Foundation of America (CCFA) to raise awareness for a disease no one likes to discuss. Pearl Jam guitarist Mike McCready was diagnosed with Crohn's disease and ulcerative colitis twenty years ago and has gone public with what he personally felt for many years was an embarrassing disease.

McCready, a spokesperson for the NW Chapter of CCFA, said, "Having struggled with Crohn's disease for more than 20 years and experienced first hand difficulties in getting a diagnosis and treatment, I want to help others learn about the disease, how it is affecting them and how to find ways to cope."

UCB, a leading global biopharmaceutical company that recently launched Crohns and Me, an information and resource website for people with Crohn's disease, joined with CCFA, in sponsoring the Pearl Jam Portland benefit concert.

Inflammatory breast cancer accounts for only 1 percent of all breast cancers -- yet this disease that mostly affects young women and teenagers can be especially aggressive. And sadly, many of the symptoms  -- inflammation, irritation, itching, redness, blotching, and increase in size -- are mistaken for infection. Not until further, more serious symptoms arise does breast cancer become a possible explanation. A breast may become firmer, warmer, and may grow in size more each day. Although distinct lumps are not apparent, the skin may become dimpled and increased tenderness can occur. Large veins may surface, and cancer may spread in sheets or nests instead of from a solid tumor -- making it virtually impossible to detect a lump. While mammograms are usually ineffective for detecting this cancer, certain biopsies and MRI testing can reveal and confirm a diagnosis -- which years ago was much scarier than it is today with new studies and research and therapies that can better fight this aggressive form of cancer.

A combination of the drugs Lapatinib and Capecitabine have been used to treat inflammatory breast cancer in women who have not responded to standard therapies. And this combination is doubling the patient's survival time. Like like the drug Herceptin -- used for many young women with another aggressive form of breast cancer -- these drugs may be the innovative new approach for saving even more young women.

Studies show that nighttime heartburn increases the risk of developing other serious conditions, including cancer of the esophagus. Day or night, chronic reflux can gradually damage the esophagus. It may lead to inflammation and scar tissue that narrows the esophagus. In some people, chronic heartburn can lead to Barrett's esophagus, changes in the cells that increase the risk of esophageal cancer. But nighttime heartburn tends to leave acid in the esophagus longer, and therefore may cause more damage than daytime heartburn.

Healing Heartburn written by Lawrence J. Cheskin, MD and Brian E. Lacy, MD of Johns Hopkins School of Medicine in Baltimore, MD discusses how acids from the stomach can cause serious damage to the esophagus if left untreated. It can also cause chronic insomnia and difficulty working through the pain.

Some common ways to help stop heartburn are not eating two or three hours before you go to bed; putting blocks under the top of the mattress to elevate the head 4 to 6 inches; chewing gum to increase saliva which coats the esophagus with natural bicarbonate; and avoiding foods that can lead to heartburn -- such as alcohol, chocolate, coffee, carbonated drinks, citrus fruits and juices, tomatoes, pepper, vinegar, catsup and mustard, and spicy or fatty foods.

As in most cases where natural remedies and diets will not take care of the situation, you should consult your doctor for a more complete check up and diagnosis.