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Posts with tag injections

Growth factor drugs boost leukemia risk after breast cancer

Chemotherapy sent my blood counts spiraling on two separate occasions. Both times I landed in the hospital. And during my second stay, it took several daily injections of Neupogen -- a growth factor immunity drug -- to push my white blood counts from a low 1,200 to a whopping 58,000.

The only side effect I suffered as a result of this drug was aching bones and joints. This was temporary and not such a big deal. What might be a big deal for breast cancer survivors like me, however, is the result of a new study suggesting there may be a risk of leukemia from these immunity boosting drugs.

These drugs, G-CSF (such as Neupogen) and GM-CSF (such as Leukine) may cause rare cases of leukemia, says Columbia University's Dawn Hersmand whose study is published in yesterday's Journal of the National Cancer Institute.

It's already been established that chemotherapy itself can cause leukemia. And Hersmand's study showed 1.04 percent of women who did not receive growth factors developed leukemia from chemotherapy alone. But 1.77 percent of women treated with G-CSF or GM-CSF developed the disease. While the drugs appear to statistically double the risk, the actual risk still remains quite small. And researchers say the benefits of the drug right now outweigh the risks.

Chemopause may help women survive breast cancer

Some women opt to remove their ovaries to prevent breast cancer recurrence. I considered it -- and then decided I would not take such an extreme measure when I wasn't all that sure I was done having children.

Now, ovary removal may not be necessary -- because a new chemical equivalent of surgery allows women to temporarily shut down their ovaries while preserving their fertility.

The shutdown of the ovaries is called chemopause, and women who choose to go this route receive monthly injections -- considered a super-hormone treatment -- of a drug that blocks the male hormone testosterone and is often used to treat prostate cancer.

Chemopause has big advantages. It doesn't require surgery. And it's not permanent. Women who want to have children can stop the treatment in order to conceive. And women who have trouble with side effects can discontinue use of the surgery-sparing drugs.

The ovary-suppressing drugs -- triptorelin, goserelin, leuprolide, and buserelin -- can be used in place of or on top of standard chemotherapy and hormone therapy and are showing promise in their ability to decrease incidences of breast cancer recurrence.

Medical professionals agree there is value in ovarian suppression. Studies show women whose periods do not return after chemotherapy -- which often causes early menopause -- have lower relapse rates than women whose periods resume. So shutting down the ovaries and stopping menstruation may not be such a bad idea -- and not such an extreme measure either.

Thirteen year old girl is the first in Britain to have the new cervical cancer vaccine

A thirteen year old London girl has become the first in the country to receive the cervical cancer vaccine. The vaccine, Gardasil, launched in Britain last week, protects against the main viruses that cause cervical cancer. Gardasil targets the human papilloma viruses (HPV), which can be transmitted through sex.

Hollie Anderson's mother, Lisa, had the vaccine given to her daughter privately after seeing her own mother battle against cancer. She did this because the government has not yet issued a guidance on which groups will be routinely immunized. Mothers are taking their daughters to private clinics instead to get the vaccination. Dr. George Kassianos, the Royal College of General Practioners' immunization spokesman said: "This vaccine is available on prescription today, but patients should wait for the Department of Health to give us guidance. Everyone agrees that this is a great leap forward. I would ask that department to fast track a decision".

There are 2,800 new cases of cervical cancer diagnosed in Britain every year. About 1,000 women will die of the disease. Mrs. Anderson said "When I found out from our doctor that these injections were becoming available it wasn't a difficult decision to make" I asked Hollie and she said she wanted it. it was her decision. Afterwards she said 'Thank you mum, I know you're protecting me against a disease'.

Moving forward sometimes means trashing part of the past

Several boxes containing injections of Neulasta have lined the bottom of my refrigerator for more than a year. They are left-overs from chemotherapy -- from a time when one needle pierced the skin on my arm after each chemo treatment to keep my blood counts in a safe range. I've looked at them day after day after day, and I've allowed them to sit in the same exact spot for all this time. But today, they are in the trash -- not because I made a conscious choice to throw them away but because water spilled all over the inside of my refrigerator and left them soggy and damaged. Surely I would not have used them in this condition, I thought -- so I tossed them. But really, I would not have used them anyway. They were old -- probably past their expiration date -- and I am not receiving chemotherapy anymore. I had absolutely no use for them. But I kept them for safety or comfort or some other impractical reason -- for the same reason I keep a basket full of old medication in my kitchen cupboard. It's all cancer-related -- most of it never touched because I don't really like taking medication, even when necessary. So this stock-piling tendency defies all logic for me. Until today -- when part of my past sits in a white trash bag, ready for the curb, and the rest of it is soon to be trashed. So I can continue moving forward. Away from cancer. For good.

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