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Posts with tag investigation

Cisplatin works for triple-negative breast cancer

It's called triple-negative breast cancer and it manifests itself in the lack of expression of two cell surface proteins -- estrogen and progesterone receptors -- and also the protein HER2.

It's a disease that does not typically respond to treatment with standard chemotherapy drugs and therefore, diagnosis can come with a poor prognosis. But a new study out of Massachusetts General Hospital Cancer Center in Boston indicates this type of disease is sensitive to the drug cisplatin.

The study, appearing online in the April 19 Journal of Clinical Investigation and in the journal's May print issue, shows that triple-negative breast cancer expresses larger amounts of two proteins, delta-Np63 and TAp73. Delta-Np63 binds to TAp73 and prevents it from killing cancerous cells. Cisplatin does the trick, though, and releases TAp73 from delta-Np63. This causes the cells to die and offers hope for a sometimes hopeless disease.

Connecting the clues in Australia cancer cluster

The ABC building in the Brisbane suburb of Toowong -- subject of a December 2006 post -- has been officially vacated following an investigation that turned up a cancer cluster among female employees.

Over the past 11 years, 10 women from this one building have been diagnosed with breast cancer. Eight of the women worked in the ABC newsroom, and most had been there for more than five years. The breast cancer risk for these women was six times higher than for the general population of women in the area. And while the investigation continues and clues are beginning to connect, the big question -- Why? -- has still not been answered.

It has been determined it is highly unlikely the increase in breast cancer was caused by exposure to radio frequency, low frequency electromagnetic radiation, or chemical contamination. According to experts, had any of these factors been at play, there would have been a rise in cancer among male employees as well as female employees. Therefore, it appears something specific to women has caused this cluster.

Perhaps clues will emerge from an analysis of lifestyle influences -- like smoking, diet, and alcohol and medication use -- and already women have answered questions pertaining to body weight, height, level of physical activity, and reproductive history.

One common theme among women is the use of oral contraceptives for periods varying from two to 18 years. Other interesting findings include the average number of babies born to the women -- 1.6 -- and the breastfeeding practices of the women -- each woman with a child breastfed for an average of 2.3 to 12 months -- and the educational background of the group -- of the 10 women, six have college degrees.

Experts says these are important factors. Early puberty, late menopause, lack of breastfeeding, use of oral contraceptives, and the trend of older mothers having fewer babies all can influence breast cancer risk. And so can level of education. Research shows increased rates of breast cancer in women with white collar jobs -- which is related to socioeconomic status and late childbearing.

Everything is important really -- because as breast cancer rates continue to skyrocket, all possible reasons need to be considered.

One in eight women in Australia will be diagnosed with breast cancer before the age of 85. About 13,261 women were diagnosed with breast cancer in 2006. And it is predicted that 14,818 will be diagnosed in 2011.

Breast cancer cluster closes ABC studio in Australia

An ABC news team in Australia abandoned its Brisbane radio studio yesterday after an investigation revealed there is something about the workplace causing breast cancer.

It's not clear what the cause may be, but the five-month-long investigation concluded a breast cancer cluster is related to the office environment.

Twelve women who worked at the Brisbane Toowong office had been diagnosed with breast cancer over the past 11 years. Eight of these women worked in the newsroom. Most had been there for more than five years.

ABC managing editor Mark Scott would not move his staff earlier this year when 100 staff members walked off the job in July, demanding relocation. He said it would take evidence -- not just suspicion -- of a breast cancer cluster for him to agree to relocation. Now he has evidence.

The investigation report shows women who worked at this office reported breast cancer at a rate 11 times higher than the general working community.

In addition to the relocation, all female staff at Toowong office were offered free mammograms and free counseling services during the investigation. Yesterday, Scott extended the offer to women at other ABC sites in Australia.

FDA warning popular prescription drugs counterfeit

Prescription drugs purchased online from Canadian pharmacies were intercepted before they reached the US, and after preliminary laboratory tests were found to be counterfeit. The U.S. Food and Drug Administration (FDA) is warning consumers who may have obtained prescription drugs from Mediplan Prescription Plus Pharmacy or Mediplan Global Health in Manitoba, Canada not to take the medication as it may not be safe.

The drugs in question are Lipitor, Diovan, Actonel, Nexium, Hyzaar, Ezetrol or Zetia, Crestor, Celebrex, Arimidex, and Propecia. Most of the drugs are prescribed for cholesterol disorders and high blood pressure; Actonel for osteoporosis in postmenopausal women; Nexium for gastroesophageal reflux disease; Celebrex for arthritis-related pain; Propecia for male-pattern baldness and Arimidex is a breast cancer chemoprevention medication.

Interestingly, the FDA conducted an investigation last year and discovered that nearly half of the imported drugs they confiscated from four selected countries were shipped to fill orders that consumers believed they were placing with Canadian pharmacies. The drugs did not come from Canada. According to the FDA, 85 percent actually came from 27 other countries around the globe. Buyer beware.

Woman treated with experimental cancer drug without consent

We recently posted Elephant Man drug trial victim showing signs of cancer, about a horrific ordeal involving six healthy young men who volunteered at Northwick Park Hospital, in London as participants in a clinical trial for a drug called TGN1412, designed to treat leukemia, autoimmune and inflammatory diseases.

According to the men, they were told by doctors there would be no serious short-term or long-term side effects from participating in the drug trial. That wasn't the case. The participants were misled regarding the safety of the experimental drug -- everything went terribly wrong -- and one of the six men has now been told he is showing signs of cancer.

Another egregious event has occurred on the other side of the pond, according to news of an allegation made by a woman who claims she was used as an experimental cancer drug guinea pig without consent.

The story began last year when Trelene Cave was diagnosed with ovarian cancer. Treated at Epsom General Hospital and the Royal Marsden Hospital in Sutton, she was later sent to St George's Hospital for a second opinion before undergoing an operation. The trouble begins when St George's Hospital doctors allegedly treated Cave with Scotroc4, an experimental cancer drug, without her informed consent. She developed a blood clot and almost died.

Cave states in the news report that, "I trusted them totally. Nobody discussed it with me. I just can't understand it."

St George's Healthcare Trust has apologized to her and her husband Norman for the incident. An investigation has been called for into whether St George's Hospital doctors side-stepped ethical guidelines in treating Cave without her knowledge.

Thanks to Joel Arellano of Autoblog for this story tip!

Department of Health puts stop on sale of Japanese aloe juice

On Monday, the sale of a Japanese brand of aloe juice was banned by the Department of Health after it was determined that it contains high levels of benzene -- seven times more than the World Health Organization recommends for maximum levels in water. Benzene is a colorless and flammable liquid with a sweet smell and was once used as an additive in gasoline. It is carcinogenic -- and has been cause for concern worldwide. So samples of the drink, produced by the Japansese cosmetics brand DHC, will be sent to the Bureau of Food and Drug Analysis for further investigation due to such concerns. In the meantime, the sale of this aloe juice, sold in convenience stores and through mail-order, will be suspended.

Senator calls home DNA tests modern day snake oil

Republican Senator Gordon Smith of Oregon calls home DNA kits for cancer and other diseases as nothing more than modern day snake oil and he believes consumers are being misled and exploited.

Smith, chairman of the Senate Special Committee on Aging, released a report from the Government Accountability Office on home DNA test products. He stated he is shocked to learn how little the federal government is doing to protect consumers in awareness and education regarding the uselessness of these products.

According to a Congressional report, home DNA tests or nutrigenetic tests, are not clinically valid and companies selling them are making unproven and ambiguous health-related predictions.

The Food and Drug Administration (FDA) and the Centers for Medicare and Medicaid Services said they were investigating the companies to determine is oversight was needed.

Goji juice cancer claims challenged

New Zealand health authorities are investigating what they feel to be extravagant health claims by companies trying to sell goji juice as a cure for cancer. In New Zealand, that kind of health claim is illegal. That kind of health claim is illegal in the United States as well.

There might be a single magical berry that can cure cancer, but without rigorous scientific study, who can say for sure? Certainly not the manufacturers of goji juice, or those who seek to profit from the sale of goji juice. Not without scientific proof.

I am inclined to believe it is healthy for you, and does provide antioxidants that do have cancer prevention value, because it is a berry. Most berries have been shown to offer cancer prevention in supplying the body with vital nutrients essential to good health. But that is far cry from believing goji juice is a cure for cancer.

Common sense would keep us from buying into flamboyant claims that can give someone diagnosed with cancer false hope. A cancer diagnosis can create intense levels of fear and sometimes, a willingness to set aside normal and sensible judgment. Most of the nutritional experts are suggesting that given the current price of a goji juice drink, similar berries, fruits and vegetables might be more cost effective in getting the same antioxidant and nutrition value.

In Wisconsin it is the teachers' fault they have cancer

ABC News Health has just published an investigative story reporting over 25 percent of the staff at a Wisconsin school have been diagnosed with cancer and the state Department of Health has decided against investigating the high incidences of cancer at the local elementary school because they don't suspect a toxic source. I have read cancer statistics and I don't believe I have ever stumbled across a percentage that high that was considered normal -- or anything to brush off as to determining cause. Understandably, teachers, parents and students at West Elementary School are afraid and upset. In the last five years,  28 of 102 of the elementary school staff members have been diagnosed with cancer.

According to the news report, teacher Heidi Swetlik and her husband showed other teachers dirty air filters they had pulled from the school's heating and ventilation system. "This is what scares us and has scared us for quite some time," Swetlik said. According to State health officials, who ran some tests, said they found only improper chemical storage, ventilation system problems, and mold. They also said the numbers at West Elementary are not out of the ordinary. There are not out of the ordinary? In fact, they say they've investigated about 40 cancer clusters in Wisconsin and found none linked to the environment inside a building. None? Cancer Cluster 101: cancer clusters are usually linked to environmental causes.

Tom Sieger, of the Bureau of Environmental Health, is quoted as saying that statistics show cancer clusters are nothing more than coincidence, and added that proper diet and exercise are important to prevent disease. What? He needs to check with the EPA about the causes of cancer clusters. "Our information on causation of cancer is imperfect," Sieger said. "But what we do know is there are certain things we can do every day with regard to our diet, with regard to exercise." No way. He did not really say that -- did he? Yes -- yes he did. Sieger has it all figured out. It's the teachers fault they have cancer. What is going on in Wisconsin?

Mistake in diagnosis

I would be so flabbergasted if this following story happened to me. Apparently a radiologist gave 17 women a positive prognosis expressing they were clear of cancer, now they have been told of a risk of death from breast cancer. I feel shocked that this could happen. Imagine how these women must feel. It seems the radiologist was the only one employed by the hospitals he worked for, so no second radiologist was there to check him, or each other for that matter. All of his tests have been recalled and have been under examination. The Government has been asked to help these women financially to be able to fight cancer, they once thought were clear of. Good Luck Ladies!

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