A half a million volunteers are being sought out by the American Cancer Society (ACS) that are willing to let researchers watch them for twenty years to see if they develop cancer.

Cancer is the second leading cause of death in the United States. The idea behind this large study is to compare it to other big studies in Europe and Asia, who are searching for environmental and lifestyle factors that cause cancer.

The group will recruit men and women between the ages of 30 and 65 who have never been diagnosed with cancer. The volunteers will give blood to be tested and answer questionnaires at various times over the next twenty years.

Eugenia Calle, managing director of analytic epidemiology at the American Cancer Society, said in a statement "This type of study involves hundreds of thousands of people, with diverse backgrounds, followed for many years, with collection of biological specimens and assessments of dietary, lifestyle and environmental exposures".

When Dr. Jian-Wei Gu went to Mississippi to study the cardiovascular system and the process of blood vessel growth, he had no idea he'd make national headlines about his research into the world of cancer.

Gu, assistant professor of physiology and biophysics at the University of Mississippi Medical Center, says his discovery of the mechanism by which alcohol consumption causes tumor growth was purely accidental.

And extremely significant.

Scientists have known for a hundred years about the link between alcohol consumption and cancer. A study from Paris in 1910 showed that 80 percent of patients with cancer of the esophagus or gastric track were alcoholics. More recently, scientists have found correlations between alcohol consumption and cancer of the mouth, pharynx, larynx, esophagus, liver, large bowel, and even the breasts. Yet lab experiments have always failed to show the effects in animals that investigators knew to be true in humans.

Until now.

It seems past studies used too much alcohol -- in concentrations of 20 percent -- and the animals just wasted away while showing no tumor growth. But when Gu used concentrations of one percent -- about one to two drinks per day in humans -- to study blood vessel growth, he detected stimulated tumor growth in both chick embryos and mice. Thus, his cancer discovery was born.

Gu has further concluded that melanoma cancers in mice grew significantly faster and larger in the mice who consumed the equivalent of one or two alcoholic drinks a day than the mice receiving no alcohol.

Gu's findings, now confirmed by other scientists, are evidence of what many have long suspected -- alcohol, even in moderation, increases cancer risk.

I know just how Jon Lester feels as he survives the cancer that took him out of the game of baseball and threw him into the arms of the medical system.

It's not the baseball I can identify with. It's the little bit of cancer fear that never really goes away. And it's the will to return to the land of the living that Lester and I share.

"When you're laying in bed at night, when you're not doing anything, you think about it a little bit," he says. "As long as I keep busy, I'm all right. Every now and again I feel something and go, `OK, what was that?' but I try not to think about it too much."

Lately, Lester is thinking mostly about a return to Boston's pitching staff, less than six months after a cancer curve ball came right at him, threatening both his promising career and his life.

Lester, whose weight was down to 190 during chemotherapy, is back up to 212 -- five pounds less than his normal weight -- and his arms are powerful, his legs strong, his appearance healthy.

As a rookie last year, Lester became the first Red Sox left-hander to win his first five decisions. He was 7-2 with a 4.76 ERA when cancer came crashing into his world. Diagnosed with anaplastic large cell lymphoma in August, Lester received treatment at both the Dana Farber Cancer Institute in Boston and at his hometown Hutchinson Cancer Research Center in Seattle. His last chemotherapy dose was delivered on December 4. His last check-up was in January. And now, newly 23 and cancer-free, Lester is ready to play ball.

Lester is prepared for his coaching staff to hold him back. He says he can tell everyone until he's blue in the face that he's ready but he knows the staff has his best interests in mind. He trusts their professional opinions, and he'll accept a return to the minors if that's what is in store for him.

"I'm not as hard on myself as I was last year," he said. "It's just a matter of enjoying playing baseball and not necessarily the result. So (I'm) just trying to enjoy things and take it day by day and live my life the best I can."

In 2006, 174,470 people will be diagnosed with lung cancer in the United States. About 92,700 men and 81,770 women will develop the disease -- the leading cause of cancer death among both men and women.

An estimated 162,460 men and women will die of lung cancer this year, accounting for 28 percent of all cancer deaths and taking more lives than colon, breast, and prostate cancers combined. While most people diagnosed with lung cancer will die within the first two years of diagnosis -- this has not changed in 10 years -- some people are cured. There are currently about 333,000 long-term survivors.

Pink never looked so warm. Check out Misty Harbor's exclusive pink puffy down jacket with fleece lining. The jacket has a price tag of $140, and $28 per jacket goes to the Breast Cancer Research Foundation.

Pick your size -- small, medium, or large -- and bundle up this winter in an all-weather quilted jacket with a zip-out microfleece bib and signature cuff mitts.

Misty Harbor has been clothing men, women, and children in stylish outerwear since 1961. Sold in specialty and department stores, Misty Harbor is known for its all-weather comfort versions of lightweight transitional jackets, rainwear, and coats for truly cold weather.

Breast cancer is widespread -- so widespread that most of us have direct personal contact with someone living with this disease. Information about breast cancer is also widespread -- so widespread that it's easy to get lost in the maze of details that define this illness that two million women in the United States are living with at this very moment. Breast cancer has its own set of definitions and facts and statistics -- and myths too. And here are seven myths that are not worth spreading.

Most lumps in the breast are cancer.
Actually, most lumps in the breast are not cancer. But every lump should still be examined and diagnosed.

Breast cancer does not occur in young women.
While most breast cancer cases occur in women over the age of 50, breast cancer can and does occur in women of all ages. I was diagnosed at age 34.

Women with large breasts have a greater risk of breast cancer.
Size does not affect risk. But it can be more difficult to examine large breasts and therefore detect a suspicious lump due to a larger amount of tissue.

A woman has little or no risk of breast cancer if she has has no family history of the disease.
Most women with breast cancer -- about 75 percent -- have no family history of breast cancer. Simply being female puts all women at risk. I have no family history of breast cancer -- but I still was diagnosed with this disease and have been treating it for almost two years.

If mammography shows nothing to worry about, then there is nothing to worry about.
Mammography can miss 10 to 15 percent of all breast cancers. So any suspicious mass should be investigated with further tests -- such as ultrasound and MRI. When my lump was examined during a mammogram, my doctor was not worried. But an ultrasound that followed revealed a solid mass -- and this was something to worry about. A biopsy came next. And then came my breast cancer diagnosis.

Once a woman is treated for breast cancer, she should avoid becoming pregnant.
Many breast cancer survivors go on to have successful pregnancies and healthy children. Women should consult their doctors, however, about current and previous treatments and should discuss any possible concerns about pregnancy after breast cancer.

Removal of the entire breast is safer than segmental mastectomy.
Survival is similar for women who have breast-conserving surgery -- like a lumpectomy -- and for those who have either a total or modified mastectomy.

It's not surprising that inaccurate information is floating around about breast cancer -- because there is so much information on the topic and much of it is not completely understood by those who study the disease every day. But we all can take an active part in our own education by researching each tidbit of news that comes our way. We can confirm it, deny it, and understand it better if we take matters into our own hands. And if we don't spread anything we just are not sure about. We owe it to ourselves -- and women everywhere -- to spread only the most accurate information about this disease we all need to better comprehend.

Women with large breast cancer tumors (5cm or larger) with negative lymph nodes do not seem likely to benefit from post mastectomy radiation. In the Journal of Clinical Oncology a study was conducted that concluded that the rate of local and regional recurrence is low in this group of cancer patients.

Physicians want to be aggressive but not give unwarranted radiation to patients. I had a lumpectomy for my breast cancer so that meant radiation was a definite for me. I also had a positive lymph node. Only one so there was a question whether my node area should be radiated due to the fact that it was usually done on lymph nodes that had three or more positive for cancer. I elected to go with the radiation to the axillary area. I guess I'm more afraid of cancer recurrence than radiation.

When it comes to portion control and weight gain, you would think that 85 food and nutritionist experts would know better than to serve themselves heaping bowls of ice cream. One of the common sense theories that links the continuing increase of weight gain in this country has been the tendency of Americans to super-size meals.

Cornell University researchers held an ice cream social and invited 85 food and nutritionist experts to the serve yourself function. The guests were given a choice of bowl and spoon size. The ones that chose the bigger bowls and bigger spoons served themselves over 50 percent more ice cream than the guests who chose the smaller bowls and spoons.

Based on the experiment, the researchers recommend anyone interested in losing weight to downsize their plates, bowls, forks and spoons. It might be as simple as that -- smaller portions on smaller plates looks like more food. Smaller portions on larger plates looks like deprivation and not exactly a motivator to eating less. Perception is everything.

Coletta Barrett believed her stomach pains were caused by a gall bladder attack after eating greasy fried food. She excused a tightening in her lower abdomen as irritable bowel syndrome, and she explained blood in her stool as a response to stress. Only after a referral to a gastroenterologist led to a colonoscopy did she learn that the upper portion of her colon was almost completely blocked by a large tumor -- a cancerous tumor. Barrett was diagnosed with colon cancer. Her colonoscopy saved her life.

Barrett never once predicted she might have colon cancer. She thought the disease mostly struck older people. She was just 42. Screening tests are not even recommended until the age of 50. She had no family history of this cancer and had no typical risk factors associated with the disease. She did not smoke, was not overweight, and drank very little. But she did in fact have colon cancer -- shocking as it was -- and doctors believed her tumor had been growing for 18 months before detected. Fortunately, Barrett learned that her cancer had not spread. And she learned a few other things that she now shares as advice -- from her survivor point of view. These tips come from an article about Barrett in the August 1 Women's Day magazine.

• Barrett says, "know your body." And don't ignore or dismiss any changes that occur.
• Don't let embarrassment stop you from seeking help. Some symptoms can be difficult to discuss -- such as change in size and frequency of bowel movements, bloody stool, cramping, and bloating -- but still ask your doctor about them. Early detection is critical, she says.
• If diagnosed with colon cancer, learn as much as you can about the disease -- a well-informed patient has a better chance at a better outcome.

Barrett offers sound advice. And I think it is global advice. Knowing your body, discussing symptoms, and education after diagnosis are key for anyone. For everyone.

My port -- that thing that pops up from under the skin on my collarbone, that thing that by default stays in place because I can't decide whether or not to remove it -- is now officially in maintenance mode, now that my treatment for breast cancer is complete. My last Herceptin infusion was on June 28. And my first port flush was today. For as long as I keep my port -- and for as long as it has no real use -- I must have it flushed one time each month. So today, I strolled into the cancer infusion center where I've spent many hours and this time spent just a few minutes -- enough time for my usual chemo nurse to puncture the skin on top of my port, push through a rather large needle, and inject a dose of blood thinner into the lines of the port to keep clots away. The whole procedure was harmless, painless, no big deal at all. And I will return one month from today for a repeat performance.

One day these once-a-month visits may become a hassle. After all, I have to find a place for this appointment in my already-busy schedule and find childcare for my kids and find a place to park. I have to numb my port and endure a needle stick and sometimes fight traffic to get home. And the whole trip to and from the cancer center takes longer than the procedure itself. Clearly, this may be a waste of time for a port I don't even need right now. But at the moment, this visit is just what I need while I sort out the details of my post-treatment world. I need to go back to the infusion center. I need the comfort of the drive. I need to feel part of the chemo community. I need medical people swirling around me. I need a bit of hand holding. For now anyway.

Mammograms may not be solely for detecting breast cancer anymore -- they may also lead to detection of heart disease. Calcifications may be detected in the arteries of the heart during routine mammograms. Essentially, this indicates hardening of the arteries and can be a sign of heart disease. This is nothing new, really -- doctors have long thought that hardening of breast arteries relate to heart disease. But this relationship had never really been studied -- until recently. Several large studies and many smaller ones have shown a correlation between these vascular calcifications on arteries in the breast because of the similar size to the arteries in the heart. And this correlation revealed itself for one woman -- Bunnie Gleiman -- when she went for her annual mammogram and learned that she had these calcifications on the arteries in her breast. She says her mammogram saved her life -- but not from breast cancer. Now on medications for cholesterol and blood pressure, Bunnie reports that she is happy and healthy. Thanks to her mammogram.

Inflammatory breast cancer accounts for only 1 percent of all breast cancers -- yet this disease that mostly affects young women and teenagers can be especially aggressive. And sadly, many of the symptoms  -- inflammation, irritation, itching, redness, blotching, and increase in size -- are mistaken for infection. Not until further, more serious symptoms arise does breast cancer become a possible explanation. A breast may become firmer, warmer, and may grow in size more each day. Although distinct lumps are not apparent, the skin may become dimpled and increased tenderness can occur. Large veins may surface, and cancer may spread in sheets or nests instead of from a solid tumor -- making it virtually impossible to detect a lump. While mammograms are usually ineffective for detecting this cancer, certain biopsies and MRI testing can reveal and confirm a diagnosis -- which years ago was much scarier than it is today with new studies and research and therapies that can better fight this aggressive form of cancer.

A combination of the drugs Lapatinib and Capecitabine have been used to treat inflammatory breast cancer in women who have not responded to standard therapies. And this combination is doubling the patient's survival time. Like like the drug Herceptin -- used for many young women with another aggressive form of breast cancer -- these drugs may be the innovative new approach for saving even more young women.

This is my port. It looks to me like a bottle cap sewn under the skin on my chest. My son Joey -- he is five years old --  calls it my stone and his brother Danny -- he just turned three -- at one time thought everyone must have this same boo-boo. He would look for it, feel for it, hunt for it. But mine is the only port he could actually locate and now that he's getting older, he is not so concerned with it anymore.

My concern about the port is that everyone who needs chemotherapy should have one. It's the alternative to receiving IV sticks in the arms and hands and except for one quick stick that can sting -- I use a 5% lidocaine numbing cream prior to my infusion and with this miracle lotion, I don't feel a thing -- it is quick and painless. My port is a one-stop shop. Once accessed, blood can be drawn, drugs and fluids can be infused, shots can be injected, and at the end of treatment, an injection of blood thinner keeps the line clear and clean. The line attached to the port underneath my skin travels into large veins in a direct and efficient manner. While hospitalized for chemo-induced fever and low blood counts, I received antibiotics and a blood transfusion through this method. There was one stick when I was admitted and for my five-day stay, I never had to be poked again.

My port, called Infuse-a-Port®, was implanted during a minor outpatient surgery with use of a local anesthesia and it was ready for use immediately after the procedure.

My port has been used for 16 months now and will no longer be necessary at the end of July -- this is when the last drops of Herceptin will sail through my veins. Then I get to decide whether to keep my port or have it removed. It can stay for many years as long as it is flushed once each month. The superstitious part of me thinks I should keep it for future use -- if necessary -- and the rational part of me thinks I need to get rid of this bottle cap because I may never need it again. Regardless, I love my port. It has eased the discomfort of chemotherapy and for that, I am grateful.

Reuters Health is reporting that Karin B. Michels of the Harvard School of Public Health in Boston is stating the results of a research study suggest that women with larger breasts have a greater risk of developing breast cancer before menopause than women with smaller breasts do.

According to the research, if you are a skinny woman with large breasts, you have an 80 percent greater risk of developing breast cancer than skinny women with small breasts do. The researchers did not find a link between bra cup size and breast cancer risk among overweight or obese women. Michels says it's just practical common sense. "The bigger the breast, the more breast cells. The more cells you have, the more cells are at risk for a potential mutation or malignant change." I see her logic, and I am not going to spend too much time arguing over this scientific study, but I do know many small breasted breast cancer survivors.