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Posts with tag lilly

Drug slows return of pancreatic cancer

Pancreatic cancer is one of the deadliest forms of cancer. So any bit of progress on the pancreatic cancer front is a big deal. And researchers are happy to report they've found a chemotherapy drug that can help patients who have received surgery prevent a return of the disease for a longer period of time.

In a German study, participants who received Gemzar, or gemcitabine, lived an average of 13.4 months without their cancers coming back. Participants who did not receive the drug lived without the disease for 6.9 months. While the findings of this study may seem modest, they really are quite encouraging because pancreatic cancer is such a rapid killer, and patients with this disease have the worst chances of recovery.

This study, published in Wednesday's Journal of the American Medical Association, brings hope for the mere 20 percent of pancreatic cancer patients who are candidates for surgery. While surgery is the best hope for a cure, the disease still returns in the majority of cases -- so Gemzar is surely worth a shot.

It should be noted that some study authors report financial ties to Gemzar drugmaker Eli Lilly and Co. Researchers, however, report the firm had no influence in design or data interpretation.

Drug company stops clinical trial for brain cancer drug

Recent preliminary results from a Phase II clinical trial showed patients with recurrent glioblastoma multiforme, a form of primary brain cancer, experienced a significant tumor response rate with minimal side effects when treated with enzastaurin, an oral, targeted agent under development at Eli Lilly and Company.

On Thursday Eli Lilly & Co announced that it has stopped the Phase III trial of this experimental brain cancer drug. They determined that the treatment would not be any more effective than current chemotherapy treatments. The company said that it will still be evaluating enzastaurin as a potential treatment for non-Hodgkin's lymphoma. They will also be doing some trials that test the drug on other cancers, such as breast, colon, lung, ovarian and prostate.

Enzastaurin belongs to the families of drugs called protein kinase inhibitors and angiogenesis inhibitors.

Phase III trial evaluating ALIMTA for treatment of extensive stage small cell lung cancer

Eli Lilly and Company has launched a major clinical trial evaluating ALIMTA (pemetrexed for injection) in extensive stage small cell lung cancer (SCLC), a devastating and rapidly spreading form of lung cancer. SCLC is sometimes called oat cell cancer because small cell lung cancer cells resemble oat grains. Patients with SCLC are staged according to a two-stage system, being diagnosed as having either limited stage disease or extensive stage disease. About 65 to 70 percent of patients with SCLC are diagnosed with extensive stage disease and the current two year survival rate is less than 10 percent.

The GALES trial, Global Analysis of Pemetexed in SCLC Extensive Stage, is a Phase III trial that will enroll 1,820 patients with extensive stage disease. The study's primary objective is to compare the overall survival after treatment with pemetrexed plus carboplatin verses the current standard treatment of etoposide plus carboplatin.

More details on the study design and information on global recruitment sites may be found at www.clinicaltrials.gov and www.lillytrials.com or by calling 1-877-CTLILLY.

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