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Posts with tag master

Uncovered gene may flip switch on cancer

Scientists have uncovered a gene they say may be cancer's master switch.

Like a circuit breast of sorts, the newly identified gene, CHD5, has an important job -- it's a tumor suppressor that prevents cancer from developing. But when it slacks on its job, cells begin to misbehave and tumors can form.

One professor of genetics says the gene, located on chromosome 1, governs the activity of a wide array of other genes involved in tumor-suppression. Its reach is large. And the implications of improper functioning are significant.

Cancers associated with the malfunctioning gene include brain tumors such as gliomas and breast, ovarian, prostate, and colorectal cancers.

A lot of people have been looking for this gene for decades. And now that it's been located, it will influence cancer research for years to come. The discovery will provide valuable new insight into targeted drugs and diagnostics and will turn up patients who need more aggressive treatment.

"We are really excited about our discovery," says the lead investigator of the research, which is published in the journal Nature.

BBC quiz show host Magnus Magnusson dies of cancer

Magnus Magnusson, former host of the BBC quiz show Mastermind, died just days ago after a four-month battle with pancreatic cancer. He died peacefully at his Glasgow home at the age of 77.

Magnusson, a journalist, author, and presenter, is best known for his 25 years of work on Mastermind, a show he called an "undemanding program for insomniac academics late at night." His presence defined the program, a prime time BBC show watched by more than 22 million viewers, from 1972 until 1997.

"Magnus Magnusson was one of the defining faces and voices of the BBC," said Mark Thompson, the director general of the BBC. "To the contestants of Mastermind, he was a tough but always fair question-master, but behind this screen persona there was a family man of tremendous warmth and humanity."

Magnusson, who focused on his writing career after Mastermind ratings began to slump and a new host took his place, first became ill in 2004 when he was hospitalized for emergency abdominal surgery. He recovered from this episode but was diagnosed with cancer last October, on his 77th birthday.

Magnusson, who coined the quiz show phrase, "I've started, so I'll finish," is survived by his wife of 52 years and his four children.

Suzanne Somers: breast cancer survivor going her own way

Breast cancer survivor, actress and anti-pharmaceutical advocate Suzanne Somers, author of Ageless: The Naked Truth About Bioidentical Hormones, suggests that if she had it to do over again, she would not undergo radiation treatment for breast cancer. During an interview Somers shares information on bioidentical hormones with The Desert Sun's Bruce Fessier, Somers is quoted as saying, "The whole time I was lying on that radiation table and I was so sick from it, I kept thinking, isn't it radiation that gives us cancer? I couldn't get that thought out of my mind."

At the time of her breast cancer diagnosis, Somers researched Iscador, a mistletoe extract, and chose to include the alternative therapy as part of her treatment. Somers said she refused to give up her hormones, insisting that she knew more about hormones than the doctor treating her for cancer.

Somers has critics in the medical and pharmaceutical communities, and perhaps rightly so. Manipulating hormones with bioidentical hormone therapy is not nearly as simplistic as she makes it sound, nor is cancer.

In her defense, while she does hold some unorthodox beliefs about health and cancer treatment, she readily adds that her approach to health is not something she advocates for everyone. Even with that caveat, people must be interested in what she has to say, as most of her books become bestsellers. Without a formal medical education and scientific expertise to back up what she has to say, I am not certain why so many seem to be listening.

I understand cancer is a scary diagnosis, and current treatments including chemotherapy, radiation and chemoprevention drugs are an inexact science. Not everyone diagnosed with cancer is cured. But cancer is also not a disease that allows the patient a great deal of time to experiment with various treatments.

As a breast cancer survivor, with a keen interest in cancer and cancer treatments, I believe there is a place for some alternative treatments. I also believe, in time, that some of the current conventional treatments will be replaced with more effective treatments. I am relatively certain that Suzanne Somers is a lovely woman. However, I try to chose my authority figures and the experts whose advice I value very carefully. Your thoughts?

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