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Posts with tag predisposition

Breast cancer theory parallels African belief

Some scientists believe that surgery to remove a breast tumor may actually help the cancer spread and have recently reported that this same belief may be the exact reason black women are more likely to die of breast cancer.

There is apparently a widespread belief in parts of Africa and the United States that removing a tumor hastens death.

"I must say that I am sure there is more to this than just a myth," said Michael Retsky of Children's Hospital and Harvard Medical School in Boston, who shares his opinions in the International Journal of Surgery.

Retsky still urges any woman with breast cancer to have her tumor removed. And he says chemotherapy is such standard practice for any cancer threatening to spread. It's a safety net of sorts to catch the cells that get away. So if surgery causes cancer to spread, then in theory, chemotherapy should stop the spread.

Retsky, who is not suggesting any change in clinical practice, thinks the subject needs far more research. American Cancer Society experts, who tend to question this theory, agree.

"Whether or not the theory is correct, I have difficulty with the logic that they employed to get there," said oncologist Dr. Len Lichtenfeld of the American Cancer Society who says women should never delay treatment for breast cancer.

Retsky believes that perhaps surgery, by wounding the body, causes it to produce growth factors that fuel the growth of other, tiny tumors. Or maybe a primary tumor secretes some sort of factor that holds the other tumors in check. When the main tumor is removed, the smaller tumors grow.

But it could be that surgery does not cause a spread at all – and that any belief of this nature has no connection with breast cancer tendencies in black women. It may be that black women just have a genetic predisposition for more aggressive forms of the disease.

Cancer risk blamed on fate

This just in from a survey conducted by Cancer Research UK:

More than one in four British adults believe cancer results from nothing more than fate. That's 27 percent of the adult population claiming cancer risk comes down to fate and is not linked to human predisposition or behavior.

Clearly, there are proven cancer-reducing behaviors -- like stopping smoking, maintaining a healthy weight, eating fruits and vegetables, and avoiding the sun -- and the fact that so many adults don't realize that half of all cancer cases can be prevented by lifestyle is alarming.

Dr. Lesley Walker, director of information at Cancer Research UK, says education is key for this group, dominated by British residents living in the most deprived areas of Britain and those over the age of 65.

Couples consciously select embryos with low cancer risk

Chloe is a little girl conceived through in vitro fertilization -- not because her parents could not conceive in the traditional manner but because they wanted to make sure Chloe had no predisposition to cancer in her genetic makeup. And in vitro fertilization is one method of almost ensuring this. There is still a three percent chance of failure but Chloe's parents felt confident in the elective process that would mostly prevent her from inheriting a genetic mutation for colon cancer that has devastated her family -- Chloe's father carries this mutation, and his mother, grandfather, and two uncles have all died from colon cancer.

A growing number of couples are using preimplantation genetic makeup to detect a predisposition to cancers that may or may not develop later in life. Using this procedure, parents subject their tiny embryos to genetic tests to determine whether or not they harbor defective genes. Essentially, parents get to pick and choose from embryos in a petri dish which one they want. Since the embryo that became Chloe did not test positive for any defective genes, she was the chosen one. And she is now a healthy two-year-old girl.

It's an ethical minefield -- this scientific creation of human life and the picking and choosing of which embryos will survive and which ones will not. One expert says the issue centers around what is considered serious enough to warrant such testing -- and who gets to make this decision. Ethical dilemmas surrounding this issue will only continue to grow as more and more options become available. Already embryos are tested for predisposition for obesity and deafness and a mild skin condition. Some clinics even screen for gender. Some fear this practice may lead to a genetic class divide where the wealthy will become more genetically pure than the poor -- because this process is difficult and expensive, costing tens of thousands of dollars without insurance coverage.

Chloe's parents are happy they made the choice they did. Her father says he doesn't know if he could handle being told his daughter has cancer -- especially with the knowledge that he could have prevented it.

JACOB: Jews against cancer of the breast a personal story

The last word has not been spoken,
The last sentence has not been written,
The final verdict is not in.
It is never too late
To change my mind,
My direction,
To say no to the past
And yes to the future,
To offer remorse,
To ask and give forgiveness,
It is never too late to start over again,
To feel again
To love again
To hope again.
  -- prayer from JACOB

At the age of 47, Lori Sklar was diagnosed with breast cancer. It wasn't until after the diagnosis of cancer that Lori underwent genetic testing. Lori is an Ashkenazi Jewish woman who inherited the BRCA1 gene.

Continue reading JACOB: Jews against cancer of the breast a personal story

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