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Herceptin and risk for heart failure over time

Women treated with Herceptin (trastuzumab) in combination with chemotherapy for early stage breast cancer showed that after five years the risk of congestive heart failure did not increase with time.

The findings of the National Surgical Adjuvant Breast and Bowel Project (NSABP) were presented at the 43rd annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago last week.

Heart damage occurs in around 5 percent of patients treated with Herceptin. It is the most significant side effect; women with existing heart conditions cannot take the drug. The study showed that women were either susceptible to heart problems or they weren't. The risk of long-term problems is the same as the risk that is there from the beginning.

Continue reading Herceptin and risk for heart failure over time

Heart disease after Hodgkin's lymphoma treatment

Those who have been treated for Hodgkin's disease have a 3.6 fold increased risk of heart attack and a 4.9 fold increased risk of congestive heart failure than the general population.

A study was conducted to assess the long-term cardiovascular disease risk in a group of 1474 patients, who survived Hodgkin's lymphoma for at least five years.

Records showed that 28 percent received radiation only; 5 percent had chemotherapy only; 38 percent were treated with radiation and chemotherapy, which did not include anthracyclines, drugs known to damage the heart; and 29 percent received radiation plus chemotherapy with anthracyclines. Of these patients, a total of 84 percent were treated with radiation to the chest.

The study group detected 160 cases of valve disorders, 134 cases of angina, 102 heart attacks and 52 cases of congestive heart failure. Among subjects treated before the age of 20, the risk of angina and congestive heart failure were significantly higher than for those treated when they were older, suggesting that "immature cardiovascular tissue may be more vulnerable to radiation and chemotherapy."

The study team hopes that the outlook for survivors of Hodgkin's lymphoma will brighten over time, as fewer patients are receiving radiation therapy, and when they do, dosages are reduced and patients' hearts are at least partially shielded.

The recommendation for those treated for Hodgkin's is to consider some risk reducing strategies, such as treating high blood pressure and high cholesterol and advising patients to eliminate controllable risk factors.

This post isn't meant to scare anyone diagnosed with Hodgkin's that has been treated with radiation or chemotherapy. I was given an anthracycline as therapy for my breast cancer -- it does linger in the back of my mind that this drug is harmful to the heart and could cause problems later on in my life. I think that those treated for Hodgkin's, especially at a young age when treatments might have been less safe, should think about their lifestyle choices. Talk to your doctor about ways to decrease your risk of these heart problems.

Thought for the Day: Making the cut

If you are trying to ward off cancer by making a change in your smoking habits, cutting back isn't enough. Cutting out cigarettes altogether is the only way to really protect your health.

Think about this tidbit I found in the March 2007 issue of Woman's Day Magazine.

A 20-year-study of more than 50,000 people in Norway recently revealed that patients who smoked fewer cigarettes -- even those who cut back by half -- were just as likely as heavy smokers to suffer from early death due to cardiovascular disease, cancer, and other tobacco-related problems.

Thought for the Day: Consider this a wake-up call

Fewer women are getting mammograms. Facilities offering mammograms are closing. Mammogram machine usage is declining. And we don't really know why.

"We're heading in the wrong direction," says Carol Lee, professor of radiology at Yale University School of Medicine and chair of the American College of Radiology's commission on breast imaging.

"If this decline holds up, it will be very worrisome," she says.

"We're looking at a possible increase in deaths if we see this continue," according to Diana Balma, vice president of public policy at Susan G. Komen for the Cure.

Studies don't show which women -- rich or poor, young or old, educated or uneducated -- are skipping these critical screenings, but there are a few possible reasons for this dangerous drop.

Think about this:

Perhaps there are fewer facilities, staffed by fewer radiologists and technologists due to high lawsuit rates and modest reimbursement. This is scary -- because the number of women old enough to get screened is increasing.

Women may be missing out on all sorts of necessary medical care because of inadequate health insurance or other access problems.

Women may be choosing, for whatever reasons, not to get mammograms, despite strong public urging that women age 40 and older get screened one time every year.


And now think about this:

Recent news about declining breast cancer rates may not be all that good. It may not be that fewer women are developing breast cancer. It may simply be that fewer women are getting early diagnoses because of irregular or nonexistent screening.

FDA warns against common anemia drugs

Doctors prescribing anemia drugs for patients with kidney disease and cancer were urged by the Food and Drug Administration (FDA) on Friday to carefully dispense of these drugs due to an increased risk of death and other serious problems, such as blood clots, strokes, and heart attacks in patients with chronic kidney failure and rapid tumor growth in patients with head and neck cancer who receive doses higher than recommended.

The potentially harmful drugs, sold under than brand names Procrit, Epogen, and Aranesp, are genetically engineered versions of a natural protein -- called erythropoietin -- that increases the number of red blood cells. The drugs, with combined 2006 U.S. sales of $10 billion, are commonly used for patients with certain forms of kidney disease and for those receiving chemotherapy for cancer.

The FDA is adding warnings to the drugs' labels that will strongly instruct doctors to use the lowest possible dose needed to help patients avoid blood transfusions.

The FDA will also take a close look at how the drugs are marketed, including claims the drugs can improve the quality of life.

A meeting of FDA officials to further discuss this issue, believed to stem from drug overuse by dialysis centers and oncologists who make more money by using more of the drugs. is scheduled for May 10. Recommendations could lead to additional revisions of the drugs' labels.

Aspirin a no go for prevention of colon cancer

Aspirin and painkillers such as ibuprofen have been deemed too risky for use in the prevention of colon cancer, according to a federal task force.

The risk of intestinal bleeding, stroke, kidney failure, and other health problems led the US Preventative Services Task Force to conclude that taking more than 300 milligrams per day of drugs like Motrin, Advil, and Aleve is just too risky to outweigh the potential benefits of preventing cancer. And while taking less than 100 milligrams of such drugs can reduce the risk of heart disease, it does nothing to lower the rate of colon cancer.

Details about this task force study are published in Monday's issue of the Annals of Internal Medicine.

Larynx cancer linked to asbestos

The U.S. government's Institute of Medicine reported that asbestos, which is accepted as a cause of a number of respiratory ailments including lung cancer, may also be a source for laryngeal cancer. The larynx produces the sound of your voice. Each year in the United States, more than 10,000 people learn they have larynx cancer. Men are four times more likely than women to get cancer of the larynx. Occupational related issues are certainly a factor with mechanics, construction, and other jobs that handle asbestos.

A series of studies have found that certain cancers of the throat and lungs are similar, so the U.S. Senate asked the institute to investigate a potential link between asbestos and other upper-body cancers. Asbestos is also linked to mesothelioma which is a rare cancer that attacks the lining of the chest.

Smokers and smokers that drink alcohol are even more at risk to develop cancer of the larynx. Symptoms of larynx cancer are hoarseness or other voice changes,lump in the neck, a sore throat or feeling that something is stuck in your throat, a cough that does not go away, breathing problems, bad breath, earaches, and weight loss.

Passive workplace smoking fuels lung cancer

Secondhand smoke rears its ugly head once again -- this time in the form of study results revealing high levels of secondhand smoke in the workplace can double the risk of lung cancer for non-smokers.

Researchers at the University of Illinois at Chicago looked at results from 22 studies conducted in the United States, Canada, Europe, India, Japan, and China. What they found -- and published in the American Journal of Public Health -- is a lung cancer risk 50 percent higher than normal for non-smokers exposed to smoke on the job for more than 30 years. They also found risk increases with level of exposure.

"We believe that our study provides the strongest evidence to date that smoking in the workplace does present a substantial risk to workers -- and particularly to workers who are working in highly exposed areas such as bar workers or restaurant workers," lead researcher Leslie Stayner said.

Previous evidence for increased lung cancer risk caused by secondhand smoke comes from studies of non-smokers married to smokers.

Secondhand smoke -- also known as passive smoke and environmental tobacco smoke -- is smoke from a cigarette, pipe, or cigar as well as smoke exhaled from the lungs of smokers and inhaled by non-smokers. It can cause cancer, respiratory problems, and asthma in non-smokers and is leading to increased efforts by communities to ban or limit smoking in the workplace.

This week in France, bans begin in offices, stores, schools, and hospitals. Come January 2008, cafes and restaurants must also comply with bans. For now, smoking in these areas is permitted in hermetically sealed rooms without any services.

Prescription for good health -- get a dog

A U.K. researcher confirms what many dog lovers already know -- dogs are good for your health.

Apparently, dog owners are generally healthier than non-pet-owners. They have lower blood pressure and cholesterol, suffer fewer minor ailments, and stray from serious medical problems too. Dogs can prevent their owners from getting sick, help them recover more quickly when they do fall ill, and they can even warn of cancer, heart attack, epileptic seizures, and hypoglycemia, says Dr. Deborah Wells from the Canine Behaviour Centre of Queens University in Northern Ireland.

Wells, whose study is published in the British Journal of Health Psychology, says dogs buffer us from stress -- a well-known cause of illness -- and promote general well-being. Owning a dog leads to increased physical activity and increases development of social interactions -- both of which minimize stress and contribute to human health.

While Wells found those who own both dogs and cats benefit from their pets, dog owners enjoy improved health for much longer than cat owners.

Ovulation disorders cut breask cancer risk

Women with ovulation disorders -- and related infertility problems -- have a lower risk of developing breast cancer, according to a study of more than 116,000 women.

Researchers from the Harvard School of Public Health in Boston studied data from the Nurses' Health Study II and evaluated female nurses aged 25 to 42, tracking them every two years beginning in 1989 and ending in 2001.

Results of the study, reported in the Archives of Internal Medicine, revealed 1,357 diagnosed cases of invasive breast cancer. Overall, women with ovulation disorders had a 25 percent less chance of developing this disease than those without the disorder.

Also detected was an even lower risk of breast cancer for women who experienced induced ovulation for treatment of infertility. This is potentially great news -- pending more research, of course -- for women worried about breast cancer implications of infertility treatment.

Younger smokers not using proven methods to quit

Smoking is not an easy habit to break, and of the many methods tried, only a handful seem to work. Of the methods that do seem to work -- nicotine-replacement products; bupropion drugs; counseling; classes; calling a helpline or talking to a health professional -- younger smokers between the ages of 16 and 24 years who smoke and try to quit only use one of the recommended methods of help by talking to a professional. Because of this, younger smokers are less likely to be successful in quitting, according to the US Centers for Disease Control and Prevention (CDC).

During the 2003 National Youth Smoking Cessation Survey, the CDC found that younger smokers most often tried to quit smoking by cutting back on the number of cigarettes they smoked each day; not buying cigarettes; exercising; using the buddy system and trying to quit with a friend; telling others they were quitting and changing to a lighter brand of cigarette, switching to chewing tobacco, snuff, or other tobacco products. None of these methods are recommended by the US Public Health Service.

According to the National Youth Smoking Cessation Survey, 77 percent of younger smokers have tried to quit at least once without success. Over a third have tried to quit smoking numerous times without success. Researchers suggest that many younger smokers may need help with other high-risk behaviors such as binge drinking; depression or ADD/ADHD.

If you are a younger smoker who is trying to quit, the CDC encourages you to call 1-800-QUIT-NOW or talk to your physician about methods that might lead to more success. The 2-page summary of the National Youth Smoking Cessation Survey is available as a pdf document.

Family helps identify gene linked to pancreatic cancer

A decade of research specific to the inherited form of pancreatic cancer has turned up a gene that could lead to earlier diagnosis and treatment for one of the deadliest forms of cancer.

The magical gene -- called palladin -- was discovered at the University of Washington after the extensive study of one family that has lost nine members over four generations to pancreatic cancer and has nine additional members with early signs of the disease.

Washington resident Ryan Chappell, a member of this family who had his pancreas removed just before cancer could strike, is very excited about this breakthrough.

"I feel really good that my family has not suffered (in vain)," the 21-year-old says. "Something has been accomplished from their contribution."

What the Chappell family has contributed to research is an understanding of a breakdown in a gene that makes a protein for the skeleton of pancreas cells. In this one family, the gene was mutated and produced large amounts of a misshapen protein that rolls like tumbleweed through the body, migrating 50 percent faster than other cells.

Scientists hope to translate their research findings into a diagnostic test to find excess amounts of the protein and to prevent the cancer cells from moving.

For now, early detection of pancreatic cancer rare because the pancreas is deep in the body, making it difficult to feel or see tumors through imaging tests. Symptoms -- like jaundice, abdominal and back pain, and digestive problems -- usually surface only after the cancer has spread.

Cancer of the pancreas is rare but is the third-leading cause of cancer death among people age 40 to 60.

Less chance of cardiotoxicity with slower chemotherapy infusion

Anthracyclines are a type of chemotherapy that treat several different types of cancer including (but not limited to) leukemia, lymphomas, breast, uterine, ovarian, and lung cancers. Anthracyclines are technically antibiotics, although their high toxicity precludes their use as such. A major side effect from this type of chemotherapy is that it can lead to heart problems in some patients. The risk for heart problems can remain elevated long after cancer treatment is finished.

Researchers are looking to find ways to lower the risk of patients developing heart problems after treatment without sacrificing the effectiveness of the drugs. They reviewed information from six previously published clinical trials and found that if the infusion of anthracyclines are given slower, over a period of six hour or longer, it appears to reduce the risk of heart problems.

Available anthracyclines include:

  • Daunorubicin
  • Doxorubicin
  • Epirubicin
  • Idarubicin
  • Mitoxantrone

Healed by the power of flowers

Flowers can lift spirits, brighten days, and heal hurting souls. They can actually make us healthier too. And while there is not a lot of science backing this fact just yet, it's long been understood that flowers really do help us Get Well Soon.

In ancient Egypt, physicians ordered walks in gardens for patients with psychological problems. Currently, horticultural therapy is a well-established method of rehabilitation for patients with physical and mental difficulties. Medical institutions all over have created flowering spaces intended as therapeutic gardens. One study determined that 100 percent of women presented with a flower bouquet reacted with a genuine smile that involves the eyes and the mouth and indicates changes in the brain. There was no such common happiness reaction among women presented with other gifts. Further studies found that men also reacted positively to flowers. A study of cardiac patients found flower therapy improved mood and lowered heart rates, possibly reducing stress that contributes to heart disease. It seems some patients seem to forget about their pain when strolling through gardens. They forget about their pain medication too. One flower expert's research brightened her own world at a time when chemotherapy and surgery for breast cancer had her feeling pretty low. Studying flowers gave her a whole new, brighter look at the world.

Flower therapy includes almost any contact with plants. Color, texture, and scent all play a part in the relaxation and healing that results from a little flower time. Why it works is a mystery -- it could be that we associate flowers with pleasure, that flowers fulfill emotional needs, that they are the pets of the horticultural world. We breed them for traits that please us and then capitalize on how they lighten the load and enhance our moods.

The bottom line is this -- we just don't know exactly why or exactly how flowers do what they do. We just know intuitively that they work, that they spread hope and renewal and peace like nothing else.

For more information on the healing power of flowers, pick up a copy of the November 2006 issue of The Oprah Magazine.

Cancer by the Numbers: Pancreatic Cancer

My mom's best friend died from pancreatic cancer just three months after her diagnosis with the disease. One of my co-workers lost her mother to the same disease just weeks after diagnosis. Another co-worker's husband lost his battle with pancreatic cancer after a 15-month all-out fight. And a family friend has somehow been surviving this deadly disease for years now. He's the exception, defying the odds rarely in favor of long-term survival.

About 33,730 people will be diagnosed with pancreatic cancer in 2006. Many of them -- 32,300 -- will die from the disease that is rarely caught early. Pancreatic cancer is the fifth leading cause of cancer death in the United States.

Continue reading Cancer by the Numbers: Pancreatic Cancer

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