Femara (letrozole) is an aromatase inhibitor that works by suppressing the production of estrogen. In postmenopausal women estrogen is still produced in the body by the adrenal gland. Decreasing this production is a way of decreasing the risk of recurrence.

Tamoxifen on the other hand works by blocking the estrogen receptors on the cancer cell itself resulting in slower growth of the cell or cell death. Tamoxifen can be given to post or premenopausal women but Femara would only be prescribed to women that are postmenopausal. The reason being, is that a premenopausal women will still have estrogen produced by the ovaries. Femara would not be effective in this instance.

A Phase III clinical trial that is ongoing shows preliminary results that Femara is superior than Tamoxifen in women with early stage disease that are postmenopausal. The results of the study were published in the Annals of Oncology.

It's called triple-negative breast cancer and it manifests itself in the lack of expression of two cell surface proteins -- estrogen and progesterone receptors -- and also the protein HER2.

It's a disease that does not typically respond to treatment with standard chemotherapy drugs and therefore, diagnosis can come with a poor prognosis. But a new study out of Massachusetts General Hospital Cancer Center in Boston indicates this type of disease is sensitive to the drug cisplatin.

The study, appearing online in the April 19 Journal of Clinical Investigation and in the journal's May print issue, shows that triple-negative breast cancer expresses larger amounts of two proteins, delta-Np63 and TAp73. Delta-Np63 binds to TAp73 and prevents it from killing cancerous cells. Cisplatin does the trick, though, and releases TAp73 from delta-Np63. This causes the cells to die and offers hope for a sometimes hopeless disease.

A new study published in the Journal of the National Cancer Institute suggests that postmenopausal women who eat healthy amounts of plant food rich in estrogen-like compounds called lignans may reduce their risk of developing breast cancer.

Lignans are found only in certain foods. Lignans only come from plant foods, such as whole grains, nuts, seeds, and beans. The best source of lignans are flax seeds.

The study, including over fifty eight thousand French women, showed that they had a 17 percent lower risk of developing breast cancer if lignans were part of their diet compared with women having the lowest dietary lignan levels.

A diet containing lots of plant food is hypothesized to offer a breast cancer prevention strategy, however, if you have already been diagnosed with estrogen receptor positive breast cancer it is best to talk to your doctor before going on any high lignan diet. The jury is still out on whether it can help with lowering the risk of recurrence and if it is safe for ER positive breast cancers.