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Posts with tag safe

Neuvenge breast cancer vaccine appears safe, effective

Researchers are reporting that a new vaccine designed to treat breast cancer appears to be safe in women with advanced disease. It showed signs of slowing down tumor growth too.

The Neuvenge vaccine, made by Dendreon Corporation -- maker of the Provenge prostate cancer vaccine -- targets the aggressive Her-2 positive form of breast cancer, which affects 20 to 30 percent of breast cancer patients. Using immune cells from a cancer patient's own body, Neuvenge is a tailor-made therapy.

Reports about Neuvenge, published in the Journal of Clinical Oncology, indicate the vaccine did not cause any serious side effects and of the 18 women who participated in the Phase I study, there was a reduction in the size of a tumor in one patient. In three other women, the disease seemed to stabilize for as long as a year.

Continue reading Neuvenge breast cancer vaccine appears safe, effective

Investigational drug for ovarian cancer back in the news

Ovarian cancer clinical trial to test the drug Phenoxodiol was a post I did back in November of 2006.

Its back in the news again saying that so far the studies have shown Phenoxodiol to have an excellent safety profile, with few patients experiencing side effects.

New studies are also being done to help explain the mechanism by which Phenoxodiol induces cancer cell death. This drug interacts with a tumor specific protein and blocks cancerous cells from dividing, causing it to die.

Phenoxodiol also has showed some promise of restoring drug sensitivity in patients that have become resistant to treatment. The OVATURE trial that was discussed in my November post should have results out within 18 months.

Thought for the Day: Chinese herbs to the rescue

I've always heard the use of herbs and supplements and alternative therapies can be a potentially dangerous pursuit when combined with cancer treatment. But this may not be entirely true.

Think about this:

Using Chinese herbs alone or in conjunction with chemotherapy may help protect a breast cancer patient's bone marrow and immune system. It may also improve the overall quality of life for women, say researchers at the Chinese Cochrane Centre in Chengdu, China.

It is well known that women receiving chemotherapy for breast cancer experience significant short term side effects such as nausea, vomiting, fatigue, inflammation of the gut lining, decreased numbers of red and white blood cells, and decreased numbers of blood platelets. Those is search of some relief may wish to give Chinese medicinal herbs a try.

Researchers say there is conventional evidence indicating that these medicines are safe and effective. Still, "further trials are needed before the effects of traditional Chinese medicines for people with breast cancer can be evaluated with any real confidence," says one professor involved in this area of study.

Thought for the Day: About the red meat

Daily consumption of red meat increases the risk of breast cancer. Daily consumption of red meat doesn't increase the risk of breast cancer. Ahhh. Which one is it?

In a previous post, I cited research that supported the increased risk. And now I've come across something new.

Think about this:

A nutritionist from New Zealand is disputing research, published in the British Journal of Cancer, claiming that women who ate more than100g of meat each day had the highest risk of developing breast cancer.

Jim Mann, a professor in human nutrition and medicine at Otago University, says the study failed to consider other factors which may increase the risk of breast cancer. And he assures women
it's still safe to eat about 80g of red meat a day.

Read This: What You Don't Know Can Kill You

WOW, what a book -- a perfect guide for those just embarking on a medical journey and a valuable resource for people like me -- already surviving a major illness -- who wish to better manage their health care for all of time.

Author Laura Nathanson, MD, wrote What You Don't Know Can Kill You: A Physician's Radical Guide to Conquering the Obstacles to Excellent Medical Care in honor of the husband she lost after a series of misdiagnoses and for everyone wishing to prevent such tragedy in their own lives.

Nathanson offers readers techniques for identifying signs of misdiagnosis and misleading analysis of symptoms. She shares tips for preventing medical miscommunication, keeping safe in the hospital, and choosing health care plans without falling into the uncovered services trap.

The allure of this book is the easy, non-medical approach Nathanson uses as she urges everyone facing the medical world to take charge of an often inpenetrable system. For the patient who is no stranger to this world, Nathanson's words will ring abundantly true.

"When I look back on that long period of delayed diagnosis and how we were then and later bounced around from one medical specialist to another, the image that pops into my head is that of a slightly mad, grotesque volleyball game -- with the patient as the ball," she writes.

For the patient new to medical confusion, Nathanson's words will impart volumes of truth.

"Here's what I've learned, and what you must learn if you wish yourself and your loved ones to survive a bout with serious illness," she reports. "No matter who you are, physician or not, lucky or not; no matter how rich, famous, successful, good-looking, innocent, kindly or powerful; no matter how close and trusting the relationship you have with those providing your medical care -- you cannot rely on today's medical system to keep you healthy, safe and alive."

Amen.

Acupuncture for chemotherapy nausea

Delayed nausea from chemotherapy in cancer patients frequently is managed by recurrent administration of high dose corticosteroids, resulting in undesirable side effects including weight gain, growth retardation and increased risk for infections. According to the NIH Consensus Statement on Acupuncture, there have been many studies on acupuncture's potential usefulness showing promising results in aiding adult postoperative patients and chemotherapy patients with nausea, vomiting and headaches. The National Center For Complementary And Alternative Medicine offers a lot of facts on acupuncture and other alternative treatments and therapies.

To many patients acupuncture relaxes them and helps relieve stress and to some it energizes them. It is safe and most people feel no pain or very minimal pain as the hair thin needles are inserted. The U.S. Food and Drug Administration (FDA) approved acupuncture needles for use by licensed practitioners in 1996. Finding an acupuncture practitioner is as easy as getting a referral from your health care practitioners. More medical doctors themselves are getting training to do acupuncture. Be sure to check their credentials for licensing and training. A good thing to know is that acupuncture is becoming one of those alternative therapies that are more commonly covered by insurance so be sure to check your insurance coverage.

Desperately seeking sisters

The National Institute of Environmental Health Sciences needs sisters -- 18,000 sisters to be exact -- to join the nation's largest research project aimed at pinpointing the causes of breast cancer.

The Sister Study ideally will enroll a total of 50,000 women whose sisters had breast cancer. Since the study launch in October 2004, 32,000 women have been recruited. But still more are needed.

The 10-year observational study requires very little time, is available in English and Spanish, and requires women to first answer questions about diet, jobs, hobbies, and breast cancer risk factors. Later, a female health professional collects small samples of blood, urine, nail clippings, and house dust for use in analysis of environment and genetics.

Women in the United States and Puerto Rico between the ages of 35 and 74 may be eligible for the study if their sisters -- living or deceased -- had breast cancer. The study participants must have never been diagnosed with breast cancer themselves.

The Sister Study, in partnership with the American Cancer Society, NIH's National Center on Minority Health and Health Disparities, Sisters Network Inc., the Susan G. Komen for the Cure, the Y-ME National Breast Cancer Organization, and the Intercultural Cancer Council, is confidential and safe. Women are never asked to take medications, visit medical locations, or make any changes to their habits, diet, or daily life. They are simply asked to join this effort so that the mystery of breast cancer can continiue to unfold.

To volunteer or learn more about the Sister Study, visit www.sisterstudy.org or www.estudiodehermanas.org. Or call (877) 474-7837 or (866) 889-4747 for the hearing-impaired.

Some children's bath products linked to cancer

Environmental groups claim some children's bath products contain a suspected cancer-causing chemical in amounts that reach or exceed safe limits. The chemical in question -- 1,4-dioxane -- is found in products made by companies such as Johnson and Johnson, Disney, Kimberly-Clark, and Gerber, says David Steinman, head of the environmental publishing company Freedom Press.

The Environmental Protection Agency (EPA) calls this chemical, already known to cause cancer in animals, a probable human carcinogen. But there is no real regulation on the petroleum-derived chemical and the Food and Drug Administration (FDA) only recommends cosmetic companies limit the concentration of 1,4-dioxane to 10 parts per million (ppm).

Studies show Johnson's Kids Shampoo Watermelon Explosion contains the maximum recommended level of 10 ppm. They also reveal that Kid Care's Hello Kitty Bubble Bath contains 12.3 ppm of the chemical. And two adult shampoos have been found to have twice the recommended level of this chemical that is typically a manufacturing by-product.

It's been reported that nearly 57 percent of all baby soaps contain 1,4-dioxane. But Iris Grossman, director of communications at Johnson and Johnson, stresses that all of her products are within FDA limits.

Cancer is not the only risky link to children's bath products. It seems these items are also linked to early puberty development. And this is concerning because a fast-paced growth rate combined with children's porous skin increases susceptibility to toxins that can enter the bloodstream. One breast cancer expert says an increase in breast cancer risk is linked to toxic exposures during the formative years of life.

Fruit, veggies, milk lower liver cancer risk

You're in luck if you like fruit, vegetables, and milk -- because Italian researchers say these items appear to reduce the likelihood of developing liver cancer.

Diet plays a significant role in the risk of liver cancer, says the lead researcher of this study who singles out fruits and vegetables as the foods with the most protective effect.

Subjects of this study -- published in the International Journal of Cancer -- were 185 patients with liver cancer and a comparison group of 412 controls without cancer. Participants responded to questions about diet, and their answers showed that as intake of certain foods went up, the risk of liver cancer went down. Factoring out other issues possibly contributing to this indication, researchers found that high intake of milk and yogurt cut the risk of developing liver cancer by 78 percent. High consumption of white meat lowered the risk by 56 percent, and when combined with high intake of fruit, this number dropped to 52 percent.

These finding are particularly important for patients with hepatitis B and hepatitis C (HCV) infection. But overall, experts say anyone wishing to ward off liver cancer should adopt a diet rich in fruits and vegetables, limit alcohol consumption, and avoid HCV infection by practicing safe sex and never sharing needles.

Cells phones don't cause cancer

Cell phones don't cause cancer, according to a major study from Denmark that tracked 420,000 Danish cell phone users -- many of them users for more than 10 years and some for more than 20 years.

In the largest ever study to yield good news about the safety of cell phones, scientists matched phone records to the Danish Cancer Registry -- a listing that records every citizen who gets the disease -- and on Tuesday, the study results were revealed.

Cell-phone users are no more likely than anyone else to develop cancer.

But the lead researcher of this massive investigation says doubts will surely linger. There is really no biological basis for concern about radio waves, he says. But people still worry.

Cell phones beam radiofrequency energy that can penetrate the outer edge of the brain, causing suspicion about the origin of various cancers. Most research has found no link between cell phones and cancer, but the phones have never been given a definite clean bill of health either.

"As the body of evidence accumulates, people can become reassured that these devices are safe," says one cell phone researcher.

Lumpectomy technique saves patients from repeat surgery

On Sunday, for the very first time, I read a magazine article about the hospital where I received treatment for breast cancer. I had never before seen mention of my hospital, my doctors, my city in anything other than local and regional newspapers and on area television stations. I figured news about Shands Hospital at The University of Florida was out there -- in more areas than my own -- because it's a well-known facility. People travel from all over to receive treatment here. So I know it's a good place. But to see in the October 2006 issue of Good Housekeeping an actual blurb about a new kind of lumpectomy -- pioneered right here in Gainesville, Florida -- is exciting.

I am the happy recipient of this new kind of lumpectomy -- which really is not new at all. It was developed 20 years ago by the surgeon who performed my own lumpectomy, and it allows women who undergo lumpectomy the chance to avoid return trips to the operating room.

The method is called frozen section analysis, and it was first used by Dr. Edward Copland III, first director of the UF Shands Cancer Center, who was tired of waiting for pathology reports and tired of operating on patients two and three times to ensure clear tumor margins.

It all happens like this -- a surgeon removes the breast cancer tumor, takes tissue samples, freezes them in an embedding compound, and sends them to a pathologist for immediate analysis. In a typical case, this frozen section process adds just 15 minutes to the operating time. If pathology reveals more tissue must be removed, the surgeon returns to the patient, still under anesthesia, and continues surgery. The patient does not need to return for more surgery.

Surgeons at most institutions rely on a method called permanent section analysis to determine whether or not cancerous cells remain along the margins of a tumor. The technique is labor-intensive, takes days to complete, and requires patients to return for additional surgery if margins are not clear. Surgeons using the frozen section method still consult permanent sections to confirm margins are clear -- but they are mostly certain of their findings during frozen section.

Studies show frozen section analysis to be safe and effective -- and it adds just $851 to the cost of surgery, a savings considering the cost of returning for surgery as a result of permanent analysis.

There are many advantages -- but the procedure is tricky and on occasion can fail to detect some cancerous margins, indicating frozen section should continue to be used in conjunction with permanent section. Opponents of the practice say false positives could result in unnecessary mastectomy. But Copeland says this has never happened at UF -- and he would never remove a woman's breasts until permanent section confirmed it was necessary.

Despite the promise of this method, only a handful of institutions make practice of this surgery-sparing technique. Shands at UF is the only hospital in North Florida where breast surgeons perform frozen section analysis on a regular basis.

The procedure -- which is not risky, is not harmful, and clearly saves patients from returning for surgery -- is the exact procedure I received almost two years ago. Dr. Copeland removed my tumor, froze tissue samples, sent them to pathology, and 15 minutes later knew my tumor had clear margins and had not spread to my lymph nodes. He visited my family in the hospital waiting room just after surgery and told them the good news -- clear margins, no spread, a 1.1 cm. tumor, stage I. And while other tumor criteria, such as ER/PR status and HER2 status, did not come my way immediately, I at least knew the basics when I woke from surgery. No waiting. No worrying. No complaints.

Potato chips may be next hazardous food to cut from diet

I have never completely cut a certain food from my diet just because of speculation that it may cause cancer. Because I eat most everything in moderation, I have felt that anything I am ingesting is too small an amount to make any real difference. I have heard recommendations about nixing preserved foods and anything treated with hormones and refined sugar and while I try to eat a balanced, healthy diet -- with a bit of sweet stuff thrown in -- I do sometimes indulge my cravings for foods that are not very healthy. Like chips -- which writer Robert L. Wolke says he is definitely eliminating from his diet.

The chemical acrylamide -- a probable carcinogen -- has been found in fried starchy foods, especially potato chips and French fries. This chemical is not a contaminant that somehow appears in our food but is created by chemical reactions that take place during cooking at high temperatures. It's a chemical that has been used in industry and has been known to damage the central nervous system, the immune system, and the reproductive system. And it may cause cancer. Recently, acrylamide was discovered in foods at hundreds of times the .5-parts-per-billion level that is considered safe in drinking water.

Authorities in Germany have already begun enforcing regulations to minimize the amounts of acrylamide in foods. But the United States has been criticized for dragging its feet on this issue. In fact, the National Uniformity for Food Act (H.R. 4167) recently passed the U.S. House of Representatives, with 94 percent of Republicans supporting it and 64 percent of Democrats opposing. It has gone to the Senate, where it was the subject of a hearing on July 27. The act would prohibit states or local governments from setting more stringent limits on toxic substances.

Each of us can still take personal action with regard to the foods we eat -- despite what the government dictates. We can decide what to eat and what not to eat. In the interest of our health. And our future.

For information on acrylamide levels in hundreds of different foods, click here.

Kindergarten milestone sweetened by bitterness of cancer

I don't take for granted that I am alive. I am fully aware of it, consciously grateful for it, continually amazed by it. Before I was confronted with breast cancer, I still knew I could die -- in a car accident maybe -- but I thought chances were pretty good that I would make it to a ripe old age. Death was never at the forefront of my mind. I had no reason to believe that life could be snatched from me. And because of this, I am sure some pretty important moments slipped by me, virtually unnoticed. But now -- after a breast cancer diagnosis, surgery, chemotherapy, radiation therapy, and then more therapy, I realize life is not a guarantee for anyone. Me included. Even at age 36, I am not safe. I feel confident about my future -- and I believe cancer has left my body -- but my life has been threatened like never before. And that makes me wake up and take notice -- really notice -- the moments that are too important to take for granted.

My first baby boy starts kindergarten today. Before cancer, this still would have been a monumental day for us both. But now, after cancer, it's even bigger. Because I know of several moms who did not survive cancer long enough to see their children walk through their first classroom doors -- moms who thought, like me, that they would surely beat cancer and would see their kids off for every first day of school. So I am lucky to have made it to this day -- to witness the wonder of my sweet, shy, sensitive, challenging, demanding, loving boy as he leaves the comfort of home for the real world.

Two days ago, my littlest guy said, "Mommy, I love you and want to keep you forever." Joey -- the boy whose wisdom should guide him right through his first day of school -- said, "Danny, you can't have mommy forever. One day she will die, and you will never see her again." Fortunately, his harsh meaning was lost on three-year-old Danny who kept playing with whatever toy was occupying him at the time. But his meaning was not lost on me. He spoke the truth. And so I plan to soak up the kindergarten moment this morning -- and photograph it and write about it and cherish it for my days to come. And in two years, I hope to do it again with Danny as he starts off on the same path. With me by his side.

NIRScanner: portable hand held device for breast cancer detection

NIRScanner is a battery-operated hand-held infrared-based optical scanning device that the developers claim is both affordable and safe and could be used by women as an at-home personal health care solution to the early detection of breast cancer.

However, Drexel University and the University of Pennsylvania scientists state the device is not designed to replace mammography, ultrasound, or other methods of screening for breast cancer, only that it offers an additional method of detection, much the same as monthly self-exams, only far more accurate at early detection. The simple device surpasses self-exam by touch in that it can detect changes in the breast that traditional self-exam could not, and the developers state that it would alert women to seek medical attention should the device detect a problem in the breast.

The NIRScanner makes steady low beeps as it moves over the breast. Using a type of near-infrared light that travels deep into breast tissue, if the hand-held device detects a tumor the beep tone gets higher. A microchip stores the information on the size and location of the tumor as the patient performs the self-examination and the information can be taken to be analyzed on a computer by a physician.

Although the researchers state that the device proved to be accurate over 90 percent of the time, it is still being tested, and needs funding to be brought to market. To read more about the NIRScanner, they have made an illustrated brochure available as a PDF document.

Worry about hair dye and cancer colors future decisions

I never colored my hair -- until after cancer, when my once-blond hair lost to chemotherapy grew in mousy brown with touches of gray. I thought it needed some spark and dazzle so I doused my head -- and my bathroom counter and walls too -- with hair dye in an effort to brighten up my look. It worked. And I like it. But I don't like what I've now heard about a possible link between hair dye and cancer. And this is what I told a reporter from the New York Times who called me the other day. She had read my post here on the Cancer Blog about this news story -- about hair dye and cancer -- and she wanted to know more about my personal feelings as a cancer survivor and as a person with colored hair.

I told this reporter that it's a bit ironic that in 36 years, I had never applied hair dye to my hair and that only after cancer did I take the plunge -- only to learn that hair dye may be cancer causing. I told her that I wouldn't do it again -- dye my hair -- although I don't think one application of coloring chemicals will really affect me when research indicates a risk only when women use hair dye 12 or more times. But still, I don't choose to take even the smallest of risks when it comes to my health -- which has already been compromised once. I told the reporter that I have not witnessed any widespread panic among the public about this issue. And I think the people I know who color their hair will continue to do so. That's okay with me. Because when it comes down to it, I am responsible for my hair only, my health only, my life only. That's really all I can manage.

And once my colored hair grows out -- the colored hair that was photographed today for the story this reporter is writing -- I'll manage to live on with my mousy brown hair with natural gray highlights. It won't have much spark or dazzle. But it will be safe.

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