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Posts with tag shrinking

Blood pressure drugs help shrink lung cancer tumors

Lung cancer tumors in mice are shrinking -- with the help of a hormone important in the control of blood pressure.

This new discovery, led by scientists at Wake University School of Medicine, suggests some drugs used to manage blood pressure might also prevent or treat lung cancer.

This all came about when it was noticed that lung cancer rates were lower among those treated for high blood pressure with angiotensin-converting enzyme, or ACE, inhibitors. These drugs, including Capoten and Lotensin, increase levels of angiotensin-(1-7) in the bloodstream.

In studies, the angiotensin-(1-7) hormone caused a 30 percent decrease in tumor volume in mice. Tumors in mice not treated with the hormone more than doubled.

This study, published in the journal Cancer Research, is the first demonstration of the effect in animals.

Researchers search for root of pancreatic cancer stem cells

Researchers have made a stem cell discovery that may help treat pancreatic cancer -- one of the deadliest forms of the disease.

University of Michigan scientists have found cancer stem cells in pancreatic tumors that appear to drive cell tumor growth and could lead to the development of drugs to target and kill these cells.

Pancreatic cancer kills 97 percent of people diagnosed with the disease within five years. Half of all diagnosed patients die within six months of diagnosis, and this cancer -- that spreads quickly and is rarely detected at an early state -- kills 33,000 each year in the United States alone. So any improvement in the study of this disease is a true gift.

"The clinical implications of this work are significant," said Dr. Diane Simeone, director of the Gastrointestinal Oncology Program at the University of Michigan Comprehensive Cancer Centre and lead author of the study, published in the journal Cancer Research.

"We've made baby steps in improving the survival in these patients -- on the order of a few months (longer to live) -- over the past decade or so. But we really haven't had a major breakthrough in coming up with something that has the potential to provide a cure," she said.

Simeone says killing these cancer stem cells is like pulling out the root of a weed. And she says the best way to pull out the root is to target these stem cells instead of the traditional approach of shrinking tumors by killing as many cells as possible -- an approach that may be flawed because cancer stem cells tend to resist standard therapies.

Tiny implants to broadcast status of tumors

Scientists from Harvard University and Massachusetts Institute of Technology (MIT) are developing a tiny implant that will allow doctors to see what's happening with tumors from the inside out.

If all proceeds according to plan, doctors will one day be implanting tiny sensors inside tumors to determine whether or not cancer drugs are shrinking the tumors. The sensors will also determine whether or not tumors are growing.

Cancer specialists have long wished for better methods of measuring the success of drugs. While blood tests can show if a drug has reached the bloodstream, they don't reveal much about the tumor itself. This small silicone cube, no bigger than two millimeters on each side and embedded in a tumor or lymph node, would remain in the body throughout treatment while essentially broadcasting what's going on inside the tumor.

MIT scientists hope to begin animal experiments within months. Their goal is to one day make the implant as thin as the pieces of led used in mechanical pencils.

This research, funded by the National Cancer Institute, is part of a long-term project to make medical technologies that will cure cancer. It's all part of journey toward complete targeted cancer treatment. And this little implant will have the power to communicate whether or not these treatments are working.

Concert benefit held for headline-making Abraham Cherrix

Teenager Abraham Cherrix made national headlines recently with a legal battle that earned him the right to fight cancer on his own terms. Cherrix, 16, who chose to treat his disease with alternative treatments after traditional therapy failed to cure him of Hodgkin's disease, was told by the courts that his choice was not acceptable -- that he must undergo higher doses of chemotherapy in combination with radiation and followed by stem cell transplant. Cherrix ended up a winner in court and is currently receiving the therapy of his choice. But despite the legal win, Cherrix and his family are losing financially.

The Cherrix family owns a kayak company in Virginia, and spring and summer are peak seasons. Since the family had to close shop on many occasions due to court appearances, profits suffered. So on Sunday afternoon, local musicians headlined a fundraising concert -- billed as Voices for Choices -- to help with medical and court costs. Cherrix could not attend -- he's in the midst of treatment in Mississippi -- but the show went on. And while the money raised is not enough to cover all outstanding bills, it is enough to remind the family of all the caring people in the world.

Reports from family indicate Cherrix is doing well with treatment and that his tumor is shrinking. If he continues to make progress, he may be able to return home soon -- so he can thank those whose support is so much more than money can buy.

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