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Posts with tag side

Sunday Seven: Seven ways for safe and effective drug use

It is important to question your physician about the prescriptions you are given. Most doctors will talk to you about the medication prescribed, but it is still important that you know what you're taking and ask appropriate questions.

  • Know the name of the drug. This will enable you to look up information about the drug on your own. It will also enable you to discuss the drug with your doctor or another doctor for a second opinion.
  • What is the purpose of the drug? This information will help you to know and understand what this drug is supposed to do and will let you know if the treatment is actually working.
  • What are the side effects? It is helpful to be aware of the most common side effects. All drugs have some side effects. Information about side effects can be obtained by asking your doctor or pharmacist or consulting a reliable reference.

Continue reading Sunday Seven: Seven ways for safe and effective drug use

Diet drug Xenical renamed Alli, still a cancer worry

Prescription weight-loss drug Xenical hit drugstore shelves on Friday with a new name -- Alli (pronounced: "Al-eye") and with a new non-prescription strength. The newly-named drug is to be more effective with less unpleasureable side effects. Still, there's a problem surrounding this drug, regardless of its name. It's thought to cause colon cancer.

The nonprofit group Public Citizen says Alli, made by GlaxoSmithKline, has been shown in mice studies to cause pre-cancerous lesions in the colon. Since there are no long-term studies on humans, this group believes the FDA should not have approved the drug for non-prescription use. It's not clear whether or not the pre-cancerous spots will lead to colon cancer but the mere suggestion that it might is enough, says a Public Citizen spokesperson.

"What we do know is that these lesions occur much more frequently in people who do get colon cancer," he said. "Why do we recommend that everyone get a colonscopy at the age of 50? Because you pick up on these polyps when you do one. And, even though not all of the polyps are pre-cancerous, no (doctor) does a colonscopy without removing every single polyp that is found. And you do this because you know if you don't, it greatly increases the chances of getting cancer."

Continue reading Diet drug Xenical renamed Alli, still a cancer worry

Herceptin and risk for heart failure over time

Women treated with Herceptin (trastuzumab) in combination with chemotherapy for early stage breast cancer showed that after five years the risk of congestive heart failure did not increase with time.

The findings of the National Surgical Adjuvant Breast and Bowel Project (NSABP) were presented at the 43rd annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago last week.

Heart damage occurs in around 5 percent of patients treated with Herceptin. It is the most significant side effect; women with existing heart conditions cannot take the drug. The study showed that women were either susceptible to heart problems or they weren't. The risk of long-term problems is the same as the risk that is there from the beginning.

Continue reading Herceptin and risk for heart failure over time

Diabetes drug may be fast-tracked for breast cancer

Drugs currently in trials for obesity and diabetes may soon be fast-tracked for use in the fight against breast cancer. Typically, it takes many years to research and develop new drugs. But these already-developed drugs, if successful, could reach the market much quicker.

The drugs, believed to work by blocking the enzyme PTP1B, could help breast cancer patients because the enzyme is found in high levels in about 40 percent of these patients.

Studies on mice show blocking production of the enzyme significantly slowed tumor development. In some cases, it stopped the spread of the cancer and it might even stop some tumors from forming.

Continue reading Diabetes drug may be fast-tracked for breast cancer

New drug may help brain cancer patients

New hope may be an injection away for patients living with glioma, a terminal brain cancer that comes with a life expectancy of about 25 weeks post-diagnosis.

A new vaccine called Vitaspen is made by using tissue extracted from each person's cancerous tumor. The tissue is used as a unique footprint for the vaccine that targets destructive tumor tissue while sparing healthy tissue in the same region.

Vitaspen is only in the first stage of clinical human trials, but researchers are pleased with the promise of the new drug -- particularly the benefits trial participants are gaining form the treatment. They have reported no adverse side effects, and the drug has increased the overall survival rate.

Results of stage one trials will determine if the drug warrants stage two testing.

Thought for the Day: Chinese herbs to the rescue

I've always heard the use of herbs and supplements and alternative therapies can be a potentially dangerous pursuit when combined with cancer treatment. But this may not be entirely true.

Think about this:

Using Chinese herbs alone or in conjunction with chemotherapy may help protect a breast cancer patient's bone marrow and immune system. It may also improve the overall quality of life for women, say researchers at the Chinese Cochrane Centre in Chengdu, China.

It is well known that women receiving chemotherapy for breast cancer experience significant short term side effects such as nausea, vomiting, fatigue, inflammation of the gut lining, decreased numbers of red and white blood cells, and decreased numbers of blood platelets. Those is search of some relief may wish to give Chinese medicinal herbs a try.

Researchers say there is conventional evidence indicating that these medicines are safe and effective. Still, "further trials are needed before the effects of traditional Chinese medicines for people with breast cancer can be evaluated with any real confidence," says one professor involved in this area of study.

Gleevec stops return of rare stomach cancer

Cancer drug Gleevec, used for the treatment of chronic myeloid leukemia (CML), has been pulled out of another round of testing so it can get to work stopping the return of a rare stomach cancer. It's that good, according to findings announced on Thursday.

The promise of Gleevec should make it standard treatment for people with gastrointestinal stromal tumors (GIST), a stomach and intestine cancer diagnosed in 5,000 to 6,000 Americans each year.

The drug has already been used for patients whose disease is too advanced for surgery. Now it will be used for those whose tumors can be removed. The drug will be administered for at least one year post-surgery.

More than 600 people participated in this Gleevec trial. Each person took either Gleevec or a sugar pill for one year after surgery. After the one-year mark, cancer returned in 17 percent of people taking the sugar pill and in 3 percent of people taking the actual drug.

Since 50 to 90 percent of GIST cases recur over time, this is great news, say researchers who call Gleevec a highly targeted cancer drug with few side effects.

A different shade of chemo

It feels like summer here in Florida. Our temps topped 86 degrees last week and this kind of heat prompts my little boys to request their favorite summertime activity: swimming.

My kids don't quite understand that the temperature outside is not the same as the temperature of unheated water. And so as soon as warm weather arrives, they dash for their suits and insist we make a trip to the neighborhood pool. I oblige, convinced they'll want to head home once they submerge their piggy toes in pure ice.

But somehow, the temperature doesn't register. They plunge right in, dunk their heads and kick and flop and float. They are happy as clams, quivering lips and all. I am happy too as I watch their joyous moments from the privacy of my lounge chair, tucked away in the shade that borders my kids' perfect playland.

Thanks to chemo, I am the mommy who hides in the shadows during any sunny event. It's been two whole years since my last dose of toxic drugs, but something about the sun and the heat and the residual effects of my infused poison causes my skin to produce red, itchy, unsightly bumps. It happened last year and already this year and I'm wondering now if this will be a life-long nuisance, if I will be seeking shade for the rest of my years.

It's all OK really. Secluding myself from the sun's rays is a pretty healthy venture. And I'm not a real pool enthusiast. Any my boys are old enough to swim independently. And it's peaceful in the shade. So I'm not bitter about this unexpected side effect of chemo -- it's called UV recall -- and I'm not complaining. I'm merely marveling at the power of the drugs that hopefully killed all the cancer in my body, the drugs that seem to creep back year after year, perhaps reminding me that in the whole scheme of things, red, itchy, unsightly bumps are not such a bad life condition.

Thought for the Day: I'm too young for this

There's this guy. His name is Matthew Zachary. He's a cancer survivor, a motivational speaker, a concert pianist, and the founder of a resource portal for young adults surviving cancer.

Steps for Living, Inc. -- also known as I'm too young for this -- was created by Zachary because he wants us all to know there are awesome cancer support services out there for adolescents and young adults. He means really awesome opportunities -- like spa retreats, online forums and blogs, social networking, camping excursions, fertility education, peer counseling, financial scholarships, and more.

You may be too young for cancer, but you are not alone, says Zachary whose mantra is Get Busy Living. And this is exactly what he is doing, despite challenges and setbacks in his own cancer recovery.

Think about this, an e-mail written by Zachary for those near and dear to his heart:

I am writing to share that I have suddenly gone deaf in my left ear. The condition is called Sudden Sensory Neural Hearing Loss.

After consulting with the country's best hearing experts as well as my oncologist, it has been determined that this is unequivocally a latent, long-term side effect of my post-operative cancer treatments from eleven years ago. Evidently, the excessive radiation dosages to the left hemisphere of my brain have caused irreparable neurological damage to my cochlea, which has ceased functioning.

There may be options (cochlear implants) but I will not know more for several weeks. As you can imagine, this is a devastating blow to my personal life and music career, especially since I remember fighting so hard to regain dexterity and muscle control in my left hand when it ceased functioning prior to my initial diagnosis in 1995.

That said, it has only reinvigorated me to stay the course and continue to advocate on behalf of the more than 500,000 young adults living with, through and beyond cancer each and every year. Now more than ever, I stress the importance of recognizing that remission is not a cure and that public awareness and adequate funding for adolescent and young adult cancer survivorship programming is tantamount to that of cancer research.

This is what it means to be a cancer survivor.

To read more about Zachary's powerful journey, click here for an unbelievably moving essay -- titled The Cost Of Living: No Cure For Cancer -- written by this unbelievably grounded guy.

Searching for stillness

When I sit still in the middle of the day, I fall asleep. I'm not sure if it's a side effect of cancer or of life in general, but as a result, I keep myself moving at all times.

I'm always doing something -- writing, emptying the dishwasher, packing a school lunch, reorganizing cabinets and closets and drawers. There's always something to fiddle with, something to keep my body from crashing into a deep sleep.

My little boys have been playing with Lego all afternoon. For hours they have been content and happy and full of imagination. They've built flying boats and castles and pirate contraptions. My wish: to just sit and watch them, to absorb their words, their sound effects, their interactions.

I tried to just sit and watch, tried to hone my quiet observation skills. And then I fell sleep.

It's a dozing-off kind of sleep that creeps up on me and for brief moments, I am lost to the world, sometimes even dreaming for short periods of time. So I find I am more alert and productive in the study of my children when my mind is busy with some sort of task. It's not my ideal scenario. But I figure it's better to be awake and bonding with my boys -- even if it means I'm multitasking -- than sleeping through their special moments.

My boys are still building -- they are making flags for their ships -- and I'm awake. And writing and preparing dinner too.

A cup of Joe a day -- not so bad, researchers say

Don't give up that daily cup of coffee just yet. Studies show drinking coffee may reduce your risk of developing Parkinson's disease, diabetes, cirrhosis of the liver, and colon cancer. It's even been linked to a decreased risk of inflammatory and cardiovascular disease in postmenopausal women.

Why? According to an article in the March 2007 issue of Ladies Home Journal, it's because coffee contains large amounts of flavonoids and antioxidants -- and these combat a whole bunch of illnesses.

Now drinking too much coffee can have adverse side effects, like restlessness, anxiety, and headaches, but limiting yourself to one to four brewed cups per day seems to be a safe practice. Although for those with high blood pressure, consuming between two to four cups per day maybe a bit risky because coffee causes blood pressure to rise immediately after consumption. And all coffee drinkers should fight the urge to add sugar, flavored syrup, and whole milk to to their beverages.

A daily cup of tea seems to be healthy too. Researchers are investigating its use in the prevention of cancer, and we already know both black and green tea have significant quantities of disease-fighting flavonoids -- although not as much as coffee.

Self medication with dietary supplements can be a very risky proposition for cancer patients

How do we know what is safe when choosing vitamins? I did a post about vitamins and mentioned that I take Flintstones. Maybe Flintstones are not the best choice for an adult but I like them, they taste good. I try and eat lots of fruits and green veggies but thought that a daily supplement with lots of vitamins and minerals can give me what I might miss.

I received a comment from someone that got me thinking about what else is in the bottle of Flintstones besides the vitamins and minerals. I did look at the back of the bottle and saw a lot of strange ingredients that I know nothing about. So, I'm not advocating taking Flintstones to anyone. Just to make that clear.

If you are thinking about taking dietary supplements such as vitamins, herbals or botanicals as alternative or complementary cancer treatments you need to consider your choice carefully. Few governmental standards are in place to control the production and ensure the safety, effectiveness, and quality of dietary supplements. So, it falls to you, the consumer, to gather truthful information about using these products safely.

The American Cancer Society website lists guidelines for choosing dietary supplement products:

  • First, speak with your doctor or other health care provider about any supplement you might consider taking. He or she can probably tell you if the supplement has any risks to your health and if the supplement is safe to take with other medications you may be taking.

  • Find information on the product written by recognized medical experts or government agencies. Bring this information to your doctor's attention. You can start on the Web by visiting the National Institutes of Health's Office of Dietary Supplements at http://dietary-supplements.info.nih.gov/ and clicking on Health Information."

  • When you shop for supplements, look for the USP notation on the package label.

  • If you are shopping for a botanical supplement, make sure to find a product that uses only the effective part of the plant. Avoid botanicals that have been made using the entire plant, unless the entire plant is recommended.

  • Remember that a product described as "natural" is not necessarily safer or more effective.

  • Consider the name and reputation of the manufacturer or distributor. Is it a nationally known name? Large companies with a reputation to uphold are more likely to manufacture their products under strict, quality-controlled conditions.

  • Does the label provide a way to contact the company if you have questions or concerns about their product? Reputable manufacturers will provide contact information on the label or packaging of their products.

  • Contact the manufacturer and ask about their quality control procedures and manufacturing processes.

  • Try to avoid mixtures of many different supplements. The more ingredients, the greater the chances of harmful effects.

  • Avoid supplements priced significantly lower than comparable products; they are likely to be of lower quality.

  • Avoid products that claim to be "miracle cures," "breakthroughs," or "new discoveries," to have benefits but no side effects, or to be based on a "secret ingredient" or method. Such claims are almost always fraudulent, and the product may contain potentially harmful substances or contaminants.

  • Avoid products that claim to be effective treatment for a wide variety of unrelated illnesses.

  • Avoid products that claim to be safe or effective based solely on testimonials.

Depression in breast cancer moms affects kids

Cancer sent me into a state of depression. And it took more than a year of counseling and treatment with an anti-depressant to bring me back to a balanced and healthy level of functioning.

My type of depression -- the kind that shows up just after a cancer diagnosis -- is not uncommon. And neither is the spillover that depression can leave on the children of moms depressed because of their disease.

A study at the University of Pittsburgh -- the first to examine the relationship between children's concerns and a mother's cancer-related depression -- found children of depressed breast cancer patients were more likely to be concerned or anxious about their mother's cancer and about how the disease affects their families.

It's not surprising that kids worry about their moms during times of illness. What startled researchers, though, is the fact that children's' anxieties extended to concerns about the entire family.

The results of this study, funded by the National Cancer Institute, has clear implications. As a society, we need to think about how depression affects whole family units. Oncologists must learn to spot depression early and must swiftly assist women in finding appropriate treatment. And parents should talk openly about cancer and it's emotional side effects with their children in an effort to protect them from withdrawing, hiding their concerns, and suffering in silence.

Most estimates indicate nearly one quarter of women diagnosed with breast cancer have young children. And about 100,000 kids will be affected by a cancer diagnosis this year alone.

Thought for the Day: Pet chemotherapy not so out there

More than 47 percent of people view their pets as family members, according to a 2002 American Veterinary Medical Association survey. It makes sense then that people are routinely treating their pets for ailments that might strike a family member -- like arthritis, heart disease, diabetes, allergies, dementia, obesity, and yes, cancer.

New studies show that Americans are stuffing their pets with more drugs than ever before. They are medicating their dogs, cats, and sometimes other pets as much as they medicate themselves -- and they are doing it with many of the same human drugs they use for themselves, like steroids for inflammation, antibiotics for infection, anti-depressants for anxiety, and even new slendering drugs for obesity.

It's a big market -- pharmaceuticals for pets -- and for those who love their pets so much they can't let go, going to extremes is worth every penny.

Think about this:
  • For dogs and cats alone, Americans spent $2.9 billion on pet drugs in 2005. While this is equal to only one percent of human drug sales, the market has grown by half since 2000.
  • The U.S. Food and Drug Administration (FDA) has approved more than 40 new pet drugs in the past five years.
  • A single three-month course of pet chemotherapy can cost $3,000 -- and chemotherapy doesn't typically extend the life of an animal as much as it soothes symptoms of the disease.
  • Health insurance for pets was nearly invisible in 2002 but has gained popularity over the past few years. Premiums can cost $30 per month, and the total market is expected to climb to $500 million in the next five years.
  • Some human drugs leave pets with unexpected, sometimes deadly, side effects. The drug Rimadyl, made by Pfizer and used as a treatment for dogs with arthritis, has been shown to cause kidney and liver damage in some animals. More than 3,000 pet deaths have been attributed to this drug.
  • Some question the priorities of a society that allows for medically treating pets like they are humans. Dianne Dunning, an ethicist at N.C. State's vet school is concerned that millions of animals are lost, unwanted, and euthanized while millions are spent on pet medicines. David Rothman, an expert in medicine's role in society from Columbia University, says, "If you can't get malaria drugs in some Third World countries, what are we doing with chemotherapy for cats?"
  • Others don't flinch at the expense it requires to keep their pets alive. One man, whose dog was expected to die of lymphoma within weeks, still enjoys the company of his pet some two years later. Chemotherapy saved the dog's life and when asked if he thinks the drugs are too expensive, this man says NO -- because his dog is still here.

Chemo is tough stuff

Chemo is tough stuff. That's what my oncologist told me the day I tracked her down on the phone and told her how awful I felt. I was weak, dizzy, pale, and as close to incoherent as I'd ever been. I was so out of sorts I was convinced I would jump out of my skin at the very moment this doctor implied all I needed was a firm grip on reality.

"Do you have enough support?" she asked. "Yep," I replied. I told her my mom lives right around the corner, my sister just a few miles away. I told her friends were delivering meals and my husband was coming home from work whenever I called for him. Help was just a phone call away, and I had plenty of it. What I didn't have was medical guidance about how my body was tolerating chemotherapy. That's why I needed her.

I hung up the phone that day having accomplished nothing. And I woke up the next morning barely able to walk. I crawled into my kitchen, grabbed a banana, sprawled out on the floor, inhaled some nutrition, and called my mom. I told her I needed to have my blood examined.

My mom transported me to my oncology clinic -- we had a genetic counseling appointment there anyway so it was convenient timing -- and before long, I was hand-delivered a mask and was swiftly escorted to my very own hospital room where I stayed for five days.

The day I was admitted to the hospital, my white blood counts were 700. My body was not tolerating chemotherapy. And I'll never know why my oncologist didn't know this, didn't call me in for an evaluation when so many signs were presenting themselves, didn't offer me more than her steadfast declaration that "chemo is tough stuff."

Yes, chemo is tough. And there are all sorts of expected side effects of the dreaded treatment that patients must endure. But there are many effects patients should not have to suck up, effects that warrant immediate medical attention and can be alleviated with the right intervention.

It took days of antibiotic treatment and a blood transfusion for my body to recover from its chemotherapy attack. I often wonder what would have happened had I toughed it out at home. I suspect the outcome could have been tragic.

If I ever have the occasion to preach about the dangers of chemotherapy, which is what I am doing here, I offer a firm warning about how difficult the treatments can be, how anyone with any string of worrisome side effects should seek medical help immediately, how any oncologist who doesn't respond to an outright cry for help should be fired.

I learned many lessons from my chemo crusade. I learned how to better help myself, and I learned to report right to the emergency room the second time my blood counts plummeted. I learned to demand the care I deserve, and I found an oncologist who is a warm and caring partner in my pursuit of health. And I learned that chemo is tougher than I ever imagined, too tough for some -- like me -- to go it alone.

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