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Posts with tag stem

Drink Pink: Help support LBBC

Riedel Crystal USA has created a special limited edition wine glass with a soft pink stem and a clear bowl. A set of two of the Pink Vinum glasses sell for $50 on the Living Beyond Breast Cancer website.

If you purchase them here right on the LBBC website, 100% of the proceeds will support the educational programs and services for women effected by breast cancer.

As a national education and support organization, LBBC's goal is to improve your quality of life and help you take an active role in your ongoing recovery or management of the disease, regardless of educational background, social support or financial means. They hope the information and support offered on this site brings you comfort, empowers you to ask questions and enables you to make sound choices about health care that will help you manage a breast cancer diagnosis, through treatment and beyond

Stem cells may look, but not act, like cancer

I love it when I find research coming straight from the halls of the very hospital where I received my breast cancer treatment. It reminds me that I'm in good hands, that University of Florida researchers are on the cusp of breaking through the mysteries of cancer, that I may one day be the lucky recipient of cutting-edge discoveries, like this:

University of Florida researchers report in a paper to be published in the August issue of Stem Cells that bone marrow stem cells attracted to the site of cancerous growths often take on the appearance of the malignant cells surrounding them. While these cells look like cancer, though, they may not act like cancer. They have the same skin, says lead study author Dr. Chris Cogle. But the question is: do they have the same guts?

"Our results indicate these cells act as developmental mimics; they come in and look like the surrounding neoplastic tissue, but they aren't actually the seed of cancer," said Cogle who is affiliated with the cancer center I've called home for more than two years.

Continue reading Stem cells may look, but not act, like cancer

Is targeting stem cells the way to cure cancer?

Some scientists think that the reason cancer recurs is because we haven't gotten to the root of the disease. What they mean by the root is -- the cancer stem cells.

Stem cells can reproduce and make exact copies of themselves and can live longer than ordinary cells. Embryonic stem cells can have the potential to become many different types of cells, whereas adult stem cells are generally limited to becoming into the cell types of a specific organ.

The researchers gave the analogy of a dandelion that is growing in your backyard. You can cut the weed but if you don't kill the root the dandelion will grow back. It seems that our treatments today for cancer can kill the ordinary cancer cells but can leave the stem cells behind to grow into new tumors and spread.

So how do we kill the cancer stem cells? Well, they don't know yet. But it is promising research that I look forward to hearing more about in the future.

Stem cells used to regenerate liver tissue

In the April issue of the journal Radiology, researchers published a report that says they have used adult bone marrow stem cells to regenerate healthy human liver tissue.

When cancer invades the liver sometimes it is impossible to have surgery performed to remove the tumor. This is because there is not enough healthy liver left behind to support the body. These stems cells help to regenerate the healthy portion of the liver so surgery can be performed.

Gunther Furst, M.D, coauthor and professor of radiology, says "Our study suggests that liver stem cells harvested from the patients own bone marrow can further augment and accelerate the liver's natural capacity to regenerate itself."

Survivor Spotlight: Alese Coco is fighting 2 win

Alese was diagnosed with Hodgkin's disease when she was seventeen years old. This was back in November of 2001 and Alese has been fighting this disease on and off since that time.

After her initial treatment of the standard chemotherapy regimen for Hodgkin's, Alese had her first recurrence after only four months. Alese then received a stem cell transplant in December of 2002 and she was cancer free for two years. On November 18, 2004 it was found that Alese had another recurrence of Hodgkin's.

I have been reading Alese's journal on her blog called Alese Coco Fight 2 Win. She is a courageous young women. You can read her story here, it is very inspirational.

It has been a scary weekend since Alese's family were told that they might have to start making 'end of life' decisions. Alese was having many complications from her disease that it was threatening to take her life. Thankfully, it seems things are looking better this morning. Check out her journal and if you like leave an encouraging message!

Researchers search for root of pancreatic cancer stem cells

Researchers have made a stem cell discovery that may help treat pancreatic cancer -- one of the deadliest forms of the disease.

University of Michigan scientists have found cancer stem cells in pancreatic tumors that appear to drive cell tumor growth and could lead to the development of drugs to target and kill these cells.

Pancreatic cancer kills 97 percent of people diagnosed with the disease within five years. Half of all diagnosed patients die within six months of diagnosis, and this cancer -- that spreads quickly and is rarely detected at an early state -- kills 33,000 each year in the United States alone. So any improvement in the study of this disease is a true gift.

"The clinical implications of this work are significant," said Dr. Diane Simeone, director of the Gastrointestinal Oncology Program at the University of Michigan Comprehensive Cancer Centre and lead author of the study, published in the journal Cancer Research.

"We've made baby steps in improving the survival in these patients -- on the order of a few months (longer to live) -- over the past decade or so. But we really haven't had a major breakthrough in coming up with something that has the potential to provide a cure," she said.

Simeone says killing these cancer stem cells is like pulling out the root of a weed. And she says the best way to pull out the root is to target these stem cells instead of the traditional approach of shrinking tumors by killing as many cells as possible -- an approach that may be flawed because cancer stem cells tend to resist standard therapies.

Superior drug helps cancer patients fight fungal infections

Noxafil (posaconazole), an anti- fungal agent may be better than other anti-fungals in helping cancer patients that have GVHD.

GVHD, graft-versus host disease, is a potential complication that can happen after a stem cell transplant. What is really happening is that the new stem cells given from a donor are now giving the patient a chance to build a new immune system--hopefully one that will give a cure. The foreign immune system can begin to attack the cancer patients body that received the transplant. Just like your immune system might reject a heart transplant, the new immune system is seeing the organs of the body as foreign and attack.

To combat this from happening the patients are usually given agents that suppress the immune system. This however, can then cause infections that can quickly develop into a life threatening situation. Researchers are continuing to look for ways to combat the infections that arise.

Noxafil was compared to Diflucan in a study of 600 patients with GVHD who were also receiving therapy to suppress their immune system. The anti-fungal agent that won out was Noxafil for the prevention of fungal infections.

Cincinnati Reds pitching coach Vern Ruhle dies of cancer

Former Cincinnati Reds pitching coach Vern Ruhle died Saturday after a year-long battle with myeloma, a cancer of the bone marrow. He was 55.

Ruhle, who missed the entire 2006 season following his diagnosis, had recently undergone stem cell transplants in hopes the procedures would successfully treat his cancer. But complications of the disease rendered the attempts unsuccessful.

Ruhle served 12 years as a major league pitching coach and worked in Houston, Philadelphia, and New York before joining the Reds in 2004. He had a career record of 67-88 with a 3.73 ERA.

Ruhle is survived by his wife, Sue, his daughter, Rebecca, his son, Kenny -- and his Cincinnati Reds family.

"The baseball and Cincinnati Reds families mourn the loss of an excellent coach, wonderful husband, and loving father," the Reds said in a statement. "In his 35 years in professional and collegiate baseball, Vern touched many people inside and outside the game. We are privileged to have been a part of his life. He will be greatly missed."

Top ten health news 2006

As complied by Forbe's HealthDay, half of the top ten health news of 2006 feature issues of interest to cancer patients and the cancer community in regard to cancer research, treatment and prevention. The top health story involves the concern over cost of medical care among those with health insurance and the continually growing numbers of uninsured. A recent study shows that one in six, or 50 million people, are struggling to afford medical treatment as they now spend more than ten percent of their income on medical expenses.

After much controversy regarding ethics and morality, this year saw the approval of the first cervical cancer vaccine. The federal government recommends that girls as young as nine-years-old be given the vaccine. The Federal Drug Administration (FDA) re-approved the use of silicone breast implants. Although banned in 1992 because of concerns that silicone leakage might be linked to cancer, silicone implants were still offered to women undergoing breast reconstruction after breast cancer surgery. Supposedly the implants are now safe for all women. Some consumer advocacy groups still strongly disapprove of the FDA decision.

Another controversial issue being debated based on ethics and morality is stem cell research. According to Forbes, the majority of Americans are in favor of stem cell research and the promise it holds in the cure of cancer, heart disease, diabetes, Parkinson's disease, and many other diseases.

Lastly, scandals swept throught the research community as fake research and researchers were exposed, as was conflict of interest over questionable financial ties in the research community.

Other health news stories that made Forbe's HealthDay top ten list included: Tainted-Food Scares Rattle Public; Drug-Eluting Stents May Stay; 'Morning-After' Pill Goes OTC; Antidepressants' Link to Suicide Debated; and More Progress Against Alzheimer's Disease. You can read the Forbe's top ten list in its entirety here.

Reducing the risk of graft-versus-host disease after bone marrow transplant

Graft-versus-host disease (GvHD) is a complication that can occur after a stem cell transplant. GvHD occurs when infection-fighting cells from the donor recognize the patient's body as being different or foreign. These infection-fighting cells then attack tissues in the patient's body just as if they were attacking an infection. GvHD is often treated with steroids, though this does not always work. GvHD is a serious condition with a high death rate so researchers are constantly evaluating new ways to treat it or reduce the symptoms.

European researchers conducted a study to see if a certain type of stem cell, infused into patients with GvHD that are not responding to treatment, would be effective. Patients were treated with mesenchymal stem cells, that are specific types of stems cells that are collected from the bone marrow of a donor. These stem cells are thought to help suppress the donor's immune cells and reduce the risk of GvHD.

The researcher found that 68 percent of the patients responded, children having slightly better results. They concluded that treatment with mesenchymal stem cells appears to effectively treat recurrent GvHD that would otherwise have been fatal in a majority of patients.

New research aimed to help children who receive bone marrow transplants

Children that undergo bone marrow transplants can develop life threatening infections while the immune system is trying to regenerating itself. St. Jude Children's Research Hospital thinks they have found a better way to harvest stem cells that are more vigorous in reproducing and rebuilding the immune system. These stem cells would reduce the time it takes for the immune system to rebuild--reducing the risk of infection.

When harvesting the donated bone marrow a specific antibody is used to find the vigorous stem cells that mature and reproduce faster. They found that using a new antibody along with the one already used might prove to have better results in capturing the best stem cells needed. This could help the donated bone marrow to take hold faster and lessen the risk of the time children are exposed to serious infections.

Although the studies so far have been done on mice, the researchers believe that this is promising information that with further studies can translate into better treatment for children that need to undergo a bone marrow transplant.

Uncovering clues to brain cancer

Glioblastoma is the deadliest form of brain cancer, most often striking patients in their 50s and 60s who after diagnosis typically have only 10 to 12 months to live.

Glioblastoma is a shocking diagnosis -- and while the tumors don't tend to spread outside the brain, they resist surgery and return even when half the brain is removed. They also are resistant to most treatment. Clearly, insight into this deadly cancer is a must. Thankfully, a little slice of insight has just emerged.

Armed with findings from experiments in mice, researchers report they've discovered a clue that might help unravel the mystery of glioblastomas.

Studies show that some mice recovered from a human form of brain cancer when given bone morphogenetic proteins that appeared to interfere with the cancer growth process in stem-like cells. This leads researchers to believe the proteins could be used to stop cancer growth and prevent it from recurring.

The research is not ready for prime time, says one of the researchers who maintains there is still a long way to go. Yet the findings are promising -- and they suggest stem cells may play a critical role in tumor formation.

About 17,000 to 18,000 Americans develop brain cancer each year. Half of these patients will be diagnosed with glioblastoma.

The future of breast reconstruction with the use of stem cells

University of Pittsburgh researchers are studying the potential use of stem cells, that come from the fat in our own bodies, for breast cancer reconstruction. Breast cancer survivors may one day be able to avoid the prospect of invasive breast surgeries. This approach uses the stem cells to regenerate tissue to develop into different specialized cell types.

When the fat-derived stem cells are injected under the skin in a rat model, the cellular combination eventually formed what the researchers describe as a mound of tissue. Dr. J. Peter Rubin, M.D., assistant professor of plastic and reconstructive surgery at the University of Pittsburgh School of Medicine, said "The surgical options for breast reconstruction involve either the use of implants or a procedure whereby fat tissue is taken from another part of the body is shaped into the form of a breast. Neither is ideal nor without risk. The use of adipose or fat derived stem cells may represent a better solution for soft tissue reconstruction in breast cancer patients".

Dr. Rubin has been given a three year grant from the National Cancer Institute to further explore this unique approach.

Sick children at St. Jude create hopeful holiday gifts

The kids at St. Jude Children's Research Hospital keep busy getting better. They keep busy making holiday gifts too -- like ornaments and ceramic plates and holiday cards and gift wrap. All of their hand-crafted creations fill the 2006 St. Jude Holiday Hope Gift Book, available now and jam-packed with powerful gifts of hope.

Proceeds from gift purchases -- 84 percent of each sale -- benefit sick children in every community in every country who come to St. Jude for life-saving treatment. Like Caleb, a seven-year-old boy diagnosed in 2004 with leukemia.

Caleb was referred to St. Jude -- where no family is ever turned away because of an inability to pay -- and received treatment for three years. Caleb is now in remission and expresses his feelings through his artwork.

Anna Grace, a five-year-old who was abandoned on a roadside in China when she was one day old, was adopted by an American couple and soon after was diagnosed with a cancerous tumor on her brain stem. After surgery to remove the tumor, Anna Grace was referred to St. Jude for chemotherapy and radiation. Today, Anna Grace is healthy and only returns for check-ups every six months.

St. Jude stories of hope are plentiful. And so are the kid-created holiday gifts offered this season.

Concert benefit held for headline-making Abraham Cherrix

Teenager Abraham Cherrix made national headlines recently with a legal battle that earned him the right to fight cancer on his own terms. Cherrix, 16, who chose to treat his disease with alternative treatments after traditional therapy failed to cure him of Hodgkin's disease, was told by the courts that his choice was not acceptable -- that he must undergo higher doses of chemotherapy in combination with radiation and followed by stem cell transplant. Cherrix ended up a winner in court and is currently receiving the therapy of his choice. But despite the legal win, Cherrix and his family are losing financially.

The Cherrix family owns a kayak company in Virginia, and spring and summer are peak seasons. Since the family had to close shop on many occasions due to court appearances, profits suffered. So on Sunday afternoon, local musicians headlined a fundraising concert -- billed as Voices for Choices -- to help with medical and court costs. Cherrix could not attend -- he's in the midst of treatment in Mississippi -- but the show went on. And while the money raised is not enough to cover all outstanding bills, it is enough to remind the family of all the caring people in the world.

Reports from family indicate Cherrix is doing well with treatment and that his tumor is shrinking. If he continues to make progress, he may be able to return home soon -- so he can thank those whose support is so much more than money can buy.

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