Ovarian cancer clinical trial to test the drug Phenoxodiol was a post I did back in November of 2006.

Its back in the news again saying that so far the studies have shown Phenoxodiol to have an excellent safety profile, with few patients experiencing side effects.

New studies are also being done to help explain the mechanism by which Phenoxodiol induces cancer cell death. This drug interacts with a tumor specific protein and blocks cancerous cells from dividing, causing it to die.

Phenoxodiol also has showed some promise of restoring drug sensitivity in patients that have become resistant to treatment. The OVATURE trial that was discussed in my November post should have results out within 18 months.

The overall cure rate for the 20,000 children diagnosed with cancer in the United States each year is more than 75 percent. Sounds good -- especially when 50 years ago, most children diagnosed with cancer died. But considering that only one in three childhood cancer survivors remain healthy, perhaps this is not such good news.

Thirty years after diagnosis, about 40 percent of survivors have a serious health problem and one-third have multiple problems. Strokes, heart disease, and kidney failure are just a few of the major health concerns that plague many survivors who have entered adulthood.

Doctors have long known that cancer treatments can cause new cancers later in life. But the Childhood Cancer Survivor Study -- the largest ever childhood study of its kind -- shows there are other long-term health problems. Researchers studied 10,000 survivors -- past studies examined 200-300 survivors -- and found these survivors were eight times as likely as their siblings to develop severe and life-threatening conditions. They found survivors of bone tumors, nerve and brain cancer, and Hodgkin's disease faced the highest risk.

The source of these later-in-life health problems vary. Kidney failure may result from damage caused by chemotherapy or radiation or the infections children suffer when their immune systems are weakened. Drugs used to treat infections may also be to blame. Strokes may result from head and chest radiation.

Cancer treatment for people of all ages comes with a price. We buy time, we buy life in exchange for the unknown. But for children -- who stand to live longer than adults -- there is a greater unknown. Sadly, there is a dark side to surviving cancer.

Just before my chemotherapy for breast cancer started -- when I was fantastically frightened by the toxic drugs that were about to drip into my veins -- I was told by doctors, nurses, survivors, friends that I would be just fine. I was young and strong and tough. I would easily tolerate the beating my body was about to take. This is what I was told and actually came to believe myself. I had no other choice really than to approach chemotherapy with a fighter mentality. And so I did. And I did pretty well for my first three doses of Adriamycin and Cytoxan -- given every two weeks instead of three in a dose-dense fashion -- followed by one injection of Neulasta 24 hours later to maintain normal blood counts. And then something happened. And I did not end up tolerating the chemotherapy my gut told me was a scary endeavor.

Michael Fumento is an author, journalist, and attorney specializing in science and health issues. And he has a lot to say about the Surgeon General's recent announcement that the second-hand smoke debate is over -- that second-hand smoke does in fact kill. Fumento believes that the debate is over means if you have your doubts, then keep them to yourself -- that the topic is not up for discussion any longer. But Fumento states that we should definitely have doubts -- about the effects of second-hand smoke and about what the Surgeon General has to say about it.

A new study reveals that women who received childhood cancer treatment may enter menopause much earlier than women who are not childhood cancer survivors. Siblings were studied -- 2,800 women who did receive treatment and 1,000 sisters of cancer survivors who did not. Women who underwent ovary-removing surgery were excluded from the study -- and the study then found that eight percent of cancer survivors experienced early menopause and less than one percent of the sisters experienced the same phenomenon. The risk was highest -- 30 percent -- for those who once received radiation to the lower abdomen and who also received certain chemotherapy agents, such as cyclophosphamide. Researchers say that 30 percent may be an underestimate, however, because the study included mostly women who had not yet reached age 40. The number of childhood cancer survivors over age 40 entering early menopause is still unclear. What is clear are the unfortunate consequences of this finding that could affect family planning, middle age health, thinning bones, other problems associated with menopause.

I'm never quite sure about what foods I should eat and what foods I should not eat. Sometimes I hear that fish is healthy and recommended and then I hear that I should not eat fish at all due to concerns such as mercury levels. It seems that opinion on certain foods -- like fish and carbohydrates and dairy items -- sways and changes, which leaves me uncertain about how I might approach my diet in the best possible way. But opinion on red meat seems to be getting more and more consistent -- as more and more studies indicate that red meat is associated with a variety of health problems. And now red meat appears to raise the risk of developing pancreatic cancer, according to a Swedish report in the International Journal of Cancer.

More than 61,000 women were studied for possible effects of meat, fish, poultry, and egg consumption. After 17 years, 172 of these women were diagnosed with pancreatic cancer, and researches say it's because of the red meat. I suppose this could have been a coincidence -- and these women were destined for their diagnoses regardless of diet. But researchers conclude that long-term consumption of red meat is associated with an increased risk of pancreatic cancer -- one of the most deadly cancers that is seldom detected at an early, curable stage.

The good news from this study -- there does not seem to be a connection between pancreatic cancer and the consumption of fish and eggs. And the consumption of poultry may actually cut the risk of pancreatic cancer.

Quick autopsies -- or rapid organ donation -- may steer scientists in the direction of better diagnosing and treating the most lethal of cancers. Some 33,700 Americans will be diagnosed with pancreatic cancer this year -- and 32,300 will die. There is no early detection test for this disease and early symptoms are vague and may be mistaken for health concerns like indigestion. By the time the classic symptoms -- jaundice and itching -- surface, the cancer has typically spread and patients have only months to live. Rapid autopsies have been used before -- for Alzheimer's and prostate cancer -- but this a first in the study of pancreatic cancer and it just may lead to the discovery of what makes this cancer so aggressive and so deadly.

I clearly remember reading a pamphlet about a test that might determine with pretty good accuracy whether or not I would benefit from chemotherapy for breast cancer. This was more than a year ago and I hoped, prayed, wished upon a star that I would be a candidate for this test -- and that the result would reveal that I did not need the toxic chemotherapy that I feared with every fiber of my being. But I did not qualify for this test because it's only effective for tumors that are estrogen receptor positive -- and I am negative. So I received chemotherapy and while I've survived it, there still remains an important issue -- did I need it?