Triple-negative breast cancer means that the pathology report has shown the cancer to be estrogen receptor negative, progesterone receptor negative, and HER2 negative.

Results published in Clinical Cancer Research found that women with triple negative breast cancer have an increased risk of metastatic disease and death during the first few years after diagnoses, but not after that time period.

A study was conducted among 1,601 breast cancer patients. One hundred and eighty women (11.2%) had triple negative breast cancer.

The results of the study:

It's called triple-negative breast cancer and it manifests itself in the lack of expression of two cell surface proteins -- estrogen and progesterone receptors -- and also the protein HER2.

It's a disease that does not typically respond to treatment with standard chemotherapy drugs and therefore, diagnosis can come with a poor prognosis. But a new study out of Massachusetts General Hospital Cancer Center in Boston indicates this type of disease is sensitive to the drug cisplatin.

The study, appearing online in the April 19 Journal of Clinical Investigation and in the journal's May print issue, shows that triple-negative breast cancer expresses larger amounts of two proteins, delta-Np63 and TAp73. Delta-Np63 binds to TAp73 and prevents it from killing cancerous cells. Cisplatin does the trick, though, and releases TAp73 from delta-Np63. This causes the cells to die and offers hope for a sometimes hopeless disease.

I blogged about Diagnosis of triple-negative breast cancer back in November. This topic seemed to get many responses from women who fit into this breast cancer 'category'.

I read a report today that discussed new data that can add to the traditional pathology testing, tumor size and lymph node status to name a few, for women with triple negative disease. This would not be a new treatment for triple negative breast cancer, but I believe this information found to be very important for future discoveries that might lead to more options for triple negative breast cancer patients.

What was discussed was the assessment of basal cytokeratins and androgen receptors in patients with triple negative breast cancer. The researchers are trying to identify prognostic markers that might signal more aggressive behavior of these specific tumors.

The only thing this seems to be able to help with at the moment is getting physicians to understand if you have a triple negative breast cancer that is more aggressive, thus warranting more aggressive treatment.

For those with triple negative disease this might not seem that great, however they are studying what makes these tumors tick and I think this will eventually evolve into new targeted treatments.

Where does the time go? Even though most of us have been experiencing the height of the summer season in the form of a nationwide scorcher of a heat wave, summer is almost over for school kids and teens leaving for college. Yes, in less than a month, it's back to school. There are advertisements everywhere you look for new school supplies and new school clothes. In preparation for the new school season, Duke Health has published Back to School Tips for Healthy Eating.

The experts say it is not about counting fat grams and calories but portion control and choices. According to pediatrician Dr. Terrill Bravender, "You don't have to be obsessive about it. If you generally eat healthy, there is room for some foods that aren't as healthy."

Dr. Bravender offers these basic common sense tips:

• Involve kids in lunchbox planning. If you let them make some choices about what goes into their lunchbox, they are more likely to eat it.
• Avoid the peanut butter and jelly rut. Nothing wrong with the traditional, but try new foods. Make it a food adventure.
• While everyone is still on summer break, encourage children to prepare their own lunch. Dr. Bravender suggests easy-to-make ideas like graham crackers with peanut butter and a glass of milk; fresh fruit with cheese cubes; a hard boiled egg with whole grain crackers; yogurt with a sliced banana; granola bars with milk; or tortilla chips and bean dip made without hydrogenated oils.
  

Ultimately, as the mother, what foods come in to the home are my choosing, so I try to make nutritious choices in food purchases. But I have found great success over the years by taking my kids to the grocery store with me, and allowing them to choose between several choices I offer. We also take a look at new foods, and talk about the food item. We read ingredients. Some we decide, by group vote, to bring home and try. During the growing seasons, they are with me when I stop at a roadside stand to buy local produce straight from the field, and each year we have an annual tradition of blueberry picking enough blueberries to last most of the year ahead. Food can be fun, and learning about good food a lifetime benefit in cancer prevention.

Mayo Clinic researchers have released information from a recent study indicating that rheumatoid arthritis patients taking Humira or Remicade face triple the risk of developing skin, gastrointestinal, breast, lung tumors and lymphoma. In response to the new findings, Abbott Laboratories' Humira and Centocor's Remicade say the new study does not prove the medication is at fault, and they believe the research is flawed.

Dr. Eric Matteson, coauthor of the study, does say that the overall chance of developing cancer is small, and that the benefits for taking these medications have great benefit for rheumatoid arthritis sufferers. At the same time, he feels that patients should be made aware of the dangers -- to report any unusual symptoms to their doctor -- and to undergo annual cancer screenings recommended for the general public.