Shorter courses of radiation therapy may be in order for women with early-stage breast cancer. And the largest study to test this suggests the abbreviated treatment time in no way affects risk of recurrence.

Often, the greatest hassle of radiation is getting to and from appointments, every weekday, for many weeks. With less frequent visits, life could get a whole lot easier.

Dr. John Dewar of the University of Dundee in Scotland led a two-part study of nearly 4,500 women in the United Kingdom to test courses of radiation and found five years later that cancer recurrences were low -- about two to five percent -- for women who received both longer and shorter durations of therapy. There were so few recurrences -- 158 -- that doctors believe the treatments are equivalent. They just can't say this with certainty yet.

This is great news for patients traveling great distances to their treatment facilities. Other benefits of shorter radiation timelines are less swelling and shrinkage of breast tissue and less enlargement of blood vessels.

A new study of mice implanted with human breast cancer cells shows the spread of the disease to the lungs -- a common metastasis site -- is caused by the abnormal activation of four specific genes working together.

The study, published in the journal Nature, indicates that shutting off the genes one by one can slow the growth and spread of this cancer. But turning off all four at one time almost completely stops the process. In mice anyway.

These genes are no strangers to researchers who have known for some time about their existence and functions. They just know more about them now.

The four genes work together at every step of the metastatic process to allow a breast tumor to develop blood vessels, let tumor cells enter the vessel walls and lungs, and permit them to pass out of the lung vessels and resume growth. New analysis shows that blocking these genes significantly reduces the tangle of blood vessels, making it harder for cancer cells to escape.

Researchers, who say the four genes are among 18 they associate with breast cancer metastasis, report that one implication of this study is clear: combined use of drug therapy may be more effective at inhibiting the activity of multiple gene targets.

A sarcoma is a cancer of the connective or supportive tissue and soft tissue affecting the bones, cartilage, fat, muscle, and blood vessels. Osteogenic sarcoma or osteosarcoma is one of the most common childhood bone cancers. Soft tissue sarcomas are more common in adults than in children. In all, sarcomas constitute fewer than 1 percent of all cancers. Its treatment is made more difficult with the existence of more than 70 varieties.

New studies released by the Journal of the National Cancer Institute showed that children who survive cancers have an increased risk of developing a secondary sarcoma,compared with the general population. Tara Henderson, M.D., of the University of Chicago Department of Pediatrics, and colleagues examined the incidence of secondary sarcomas and the risk factors associated with that risk among the 14,372 participants in the Childhood Cancer Survivor Study. Overall, there were 751 second cancers diagnosed among the participants, 108 of which were secondary sarcomas such as soft tissue sarcoma, malignant peripheral nerve sheath tumors, and osteosarcoma. These sarcomas were diagnosed an average of 11 years after patients were diagnosed with their primary cancer.

Glioblastoma multiform, (GBM) is the most aggressive form of the primary brain tumors known as gliomas. The tumors do not spread throughout the body like other forms of cancer, but cause symptoms by invading the brain.

A new drug called AZD2171 (Recentin), is an angiogenesis inhibitor that blocks tumor blood supply and shows promise in treating deadly glioblastoma brain cancers. Recentin suppresses the growth of blood vessels that feed the tumors.

The preliminary findings of the Phase II study show that researchers found that Recentin could significantly reduce the size of glioblastoma tumors and can help reduce brain swelling.

"Patients with recurrent glioblastomas desperately need new, effective treatment alternatives," said study author Dr. Tracy Batchelor, chief of neuro-oncology.

In a Phase III trial involving 878 lung cancer patients, the drug bevacizumab, known as Avastin, increased the overall survival rate to 35 percent when combined with the chemotherapy drugs paclitaxel and carboplatin. Patients who were given paclitaxel and carboplatin without Avastin had a 15 percent chance of responding to treatment.

Two months ago, the Food and Drug Administration approved Avastin as a first-line treatment for patients with inoperable, locally advanced, recurrent or metastatic non-squamous, non-small cell lung cancer. Avastin works by stopping the formation of blood vessels that feed oxygen and nutrients needed for tumor growth. Because the drug is a targeted therapy, in that it leaves healthy tissue alone while going after cancer cells, some of the traditional side-effects from conventional chemotherapy, such as hair loss, nausea, or vomiting, are avoided.

According to Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Chief of Hematology/Oncology's Dr. Joan Schiller, "Twenty years ago, we thought no treatment could help patients with advanced lung cancer. Ten years ago, we found that chemotherapy could improve survival of these patients. Now, we are finding out that this very unique drug called Avastin can also help improve survival even more. Avastin is the first of this very exciting family of drugs to be approved for lung cancer, and there are several other drugs of this type under development which may prove to work even better."

This summer I had written a post about angiogenesis and Dr. Judith Folkman who had come up with the theory in the early sixties. Angiogenesis is a normal process in growth and development, as well as in wound healing. However, this is also the process that forms new blood vessels for cancer cells to survive and grow.

Angiogenesis and its complexities are still being studied so that new drugs can target the cancer's cells ability to receive a blood supply and grow. Researchers from the University of Wisconsin Madison School of Medicine and Public Health were studying a protein that regulates the maturation of blood cells and instead discovered a new part of the mechanism of angiogenesis.

The tests showed that a gene that makes a compound call NK-B can inhibit angiogenesis in four different ways which could be a promising way to halt tumor growth.

Emery Bresnick, the senior author on the study says "we have discovered a new peptide that clearly suppresses angiogenesis via a novel multi-component mechanism."

Receiving a diagnosis of breast cancer is devastating enough, then to find out you have one of the most aggressive forms of breast cancer is even more frightening.

When I was diagnosed with breast cancer I had never heard of inflammatory breast cancer (IBC). What is shocking to me now is the fact that I have come in contact with many breast cancer survivors who are not aware of inflammatory breast cancer. This leads me to believe that if some breast cancer survivors don't know about IBC then the general public probably doesn't know much about it either.

IBC is a rare form of breast cancer. Breast cancer is not just one disease, there are many different types. I was diagnosed with one of the more common types called invasive ductal carcinoma. It wasn't so common however that I was diagnosed at the age of 31.

Only about one percent to four percent of newly diagnosed breast cancers will be inflammatory breast cancer. The scariest thing is the fact that IBC is often mistaken for a breast infection which can delay diagnosis of the disease.

According to the National Cancer Institute, asparagus is the highest tested food containing glutathione, one of the body's most potent cancer fighters. Additionally, asparagus is high in rutin, which is valuable in strengthening the blood vessels and is great for the heart.

Asparagus is packed with nutrients and easy to prepare ahead for a crowd. One serving of asparagus is low in calories, very low in sodium and is a great source of potassium. Asparagus is an excellent source of folic acid and is a fairly significant source of Vitamin C, Thiamin, and Vitamin B6. It contains no fat or cholesterol of dietary significance.

Vicki's Sesame Ginger Asparagus Salad

2 lb. fresh asparagus cut into 1-1/2 inch pieces.
5 tsp. soy sauce
2 tsp. honey
2 tsp. sesame seed oil (I prefer toasted sesame oil)
2 tbsp. toasted sesame seeds
1/2 tsp. ginger powder
1 tbsp. minced garlic

Cover asparagus in salted boiling water (1 tablespoon sea salt). Cook until tender. Rinse immediately in cold water to stop cooking process and pat dry. Mix other ingredients in small mixing bowl and pour over asparagus. Can serve hot or chilled.