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Posts with tag volume

Breast cancer surgery better at high-volume hospitals

The American Journal of Public Health published a study that states women with early-stage breast cancer have a better survival if they undergo surgery at a hospital that performs large numbers of breast cancer surgeries.

To explore the link between hospital volume and breast cancer survival, researchers conducted a study among more than 11,000 Medicare beneficiaries who underwent surgery for Stage I or Stage II breast cancer. These surgeries were performed at 457 different hospitals in the United States.

Hospital volume of the number of breast cancer surgeries was defined as:

  • low volume -- zero to nineteen cases per year
  • medium volume -- twenty to thirty nine cases per year
  • high volume -- forty or more cases per year

Study participants were followed for roughly five years after surgery:

  • Compared to women treated at a low-volume hospital, women treated at a high-volume hospital were 17 percent less likely to die of any cause and 20 percent less likely to die of breast cancer.
  • Surgery at the high-volume hospital was linked with better survival among women with lymph-node negative cancer as well as among women with lymph node positive disease.

It appears that the treatment at a hospital that performs a greater number of breast cancer surgeries appears to result in better survival among women undergoing surgery for breast cancer.

Pro-vitamin E effective on HER2 positive breast cancer cells

The term vitamin E refers to a family of eight related, antioxidant compounds widely distributed in plants. Pro-vitamin E or alpha-tocopheryl succinate (Alpha-TOS) is found in the green parts of a plant. The best sources of vitamin E are the vegetable and seed or nut oils. It was first isolated from wheat germ oil, which is still a commonly used, rich source of vitamin E.

Researchers at Griffith University's School of Medical Science have shown that pro-vitamin E can reduce tumor volume on animals with high levels of HER2. The researchers think it has potential to be an inexpensive, safe and selective therapy for hard to treat breast cancers.

Jiri Neuzil, chief investigator and Associate Professor, said "Alpha-TOS has already shown promise as a potent anticancer agent in diseases such as colon cancer and mesothelioma. It induces controlled cell death or apoptosis in tumor cells".

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